Atherosclerosis

Current Issue February 2012, Vol. 220, No. 2

The new joint EAS/ESC guidelines for the management of dyslipidaemias
ESC/EAS Guidelines for the management of dyslipidaemias: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)

Issue Highlights

Local delivery of IL-2 reduces atherosclerosis via expansion of regulatory T cells
February 2012 (Vol. 220 | No. 2 | Pages 329-336)
Thore Dietrich, Thomas Hucko, Christiane Schneemann, Marleen Neumann, Andreas Menrad, Joerg Willuda, Kirstin Atrott, Dietger Stibenz, Eckart Fleck, Kristof Graf, Hans D. Menssen
Characteristics of TAV- and BAV-associated thoracic aortic aneurysms—Smooth muscle cell biology, expression profiling, and histological analyses
February 2012 (Vol. 220 | No. 2 | Pages 355-361)
Stefan Blunder, Barbara Messner, Thomas Aschacher, Iris Zeller, Adrian Türkcan, Dominik Wiedemann, Martin Andreas, Gert Blüschke, Günther Laufer, Thomas Schachner, David Bernhard
Hepatocyte-specific IKKβ expression aggravates atherosclerosis development in APOE*3-Leiden mice
February 2012 (Vol. 220 | No. 2 | Pages 362-368)
Man C. Wong, Janna A. van Diepen, Lihui Hu, Bruno Guigas, Hetty C. de Boer, Gijs H. van Puijvelde, Johan Kuiper, Anton J. van Zonneveld, Steven E. Shoelson, Peter J. Voshol, Johannes A. Romijn, Louis M. Havekes, Jouke T. Tamsma, Patrick C.N. Rensen, Pieter S. Hiemstra, Jimmy F.P. Berbée
Resveratrol increases the expression and activity of the low density lipoprotein receptor in hepatocytes by the proteolytic activation of the sterol regulatory element-binding proteins
February 2012 (Vol. 220 | No. 2 | Pages 369-374)
Takuya Yashiro, Manami Nanmoku, Makoto Shimizu, Jun Inoue, Ryuichiro Sato
Arterial pulse wave velocity in relation to carotid intima-media thickness, brachial flow-mediated dilation and carotid artery distensibility: The Cardiovascular Risk in Young Finns Study and the Health 2000 Survey
February 2012 (Vol. 220 | No. 2 | Pages 387-393)
Teemu Koivistoinen, Marko Virtanen, Nina Hutri-Kähönen, Terho Lehtimäki, Antti Jula, Markus Juonala, Leena Moilanen, Heikki Aatola, Jari Hyttinen, Jorma S.A. Viikari, Olli T. Raitakari, Mika Kähönen
Low Ankle-Brachial Index predicts early risk of recurrent stroke in patients with acute cerebral ischemia
February 2012 (Vol. 220 | No. 2 | Pages 407-412)
Georgios Tsivgoulis, Chrysi Bogiatzi, Ioannis Heliopoulos, Konstantinos Vadikolias, Eleni Boutati, Soultana Tsakaldimi, Omar S. Al-Attas, Paris Charalampidis, Charitomeni Piperidou, Efstratios Maltezos, Nikolaos Papanas
The epistasis between vascular homeostasis genes is apparent in essential hypertension
February 2012 (Vol. 220 | No. 2 | Pages 418-424)
Rahul Kumar, Azim Nejatizadeh, Mohit Gupta, Amandeep Markan, Sanjay Tyagi, S.K. Jain, M.A. Qadar Pasha
Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B
February 2012 (Vol. 220 | No. 2 | Pages 449-455)
Ada Congrains, Kei Kamide, Ryousuke Oguro, Osamu Yasuda, Keishi Miyata, Eiichiro Yamamoto, Tatsuo Kawai, Hiroshi Kusunoki, Hiroko Yamamoto, Yasushi Takeya, Koichi Yamamoto, Miyuki Onishi, Ken Sugimoto, Tomohiro Katsuya, Nobuhisa Awata, Kazunori Ikebe, Yasuyuki Gondo, Yuichi Oike, Mitsuru Ohishi, Hiromi Rakugi
Probucol therapy improves long-term (>10-year) survival after complete revascularization: A propensity analysis
February 2012 (Vol. 220 | No. 2 | Pages 463-469)
Takatoshi Kasai, Katsumi Miyauchi, Naozumi Kubota, Kan Kajimoto, Atsushi Amano, Hiroyuki Daida
Effects of the PPAR-δ agonist MBX-8025 on atherogenic dyslipidemia
February 2012 (Vol. 220 | No. 2 | Pages 470-476)
Yun-Jung Choi, Brian K. Roberts, Xueyan Wang, J. Casey Geaney, Sue Naim, Kathleen Wojnoonski, David B. Karpf, Ronald M. Krauss
Interaction of apolipoprotein E genotype with smoking and physical inactivity on coronary heart disease risk in men and women
February 2012 (Vol. 220 | No. 2 | Pages 486-492)
Jaana Gustavsson, Kirsten Mehlig, Karin Leander, Elisabeth Strandhagen, Lena Björck, Dag S. Thelle, Lauren Lissner, Kaj Blennow, Henrik Zetterberg, Fredrik Nyberg
Increased plasma levels of NGAL, a marker of neutrophil activation, in patients with abdominal aortic aneurysm
February 2012 (Vol. 220 | No. 2 | Pages 552-556)
Priscila Ramos-Mozo, Julio Madrigal-Matute, Melina Vega de Ceniga, Luis Miguel Blanco-Colio, Olivier Meilhac, Laurent Feldman, Jean-Baptiste Michel, Paula Clancy, Jonathan Golledge, Paul E. Norman, Jesus Egido, José Luis Martin-Ventura

Lymphangiogenesis in aortic valve stenosis—Novel regulatory roles for valvular myofibroblasts and mast cells
27 January 2012
Suvi Syväranta, Satu Helske, Jani Lappalainen, Markku Kupari, Petri T. Kovanen
Highlights: ► Lympatic vessels can be found in human stenotic aortic valves. ► Lymphangiogenic growth factors VEGF-C and VEGF-D are locally produced. ► Myofibroblasts and endothelial cells are their p...
The glucagon-like peptide 1 analog liraglutide reduces TNF-α-induced oxidative stress and inflammation in endothelial cells
27 January 2012
Aya Shiraki, Jun-ichi Oyama, Hiroshi Komoda, Machiko Asaka, Aiko Komatsu, Masashi Sakuma, Kazuhisa Kodama, Yoshiko Sakamoto, Norihiko Kotooka, Tetsuaki Hirase, Koichi Node
Highlights: ► Liraglutide can normalize TNF-α-induced pro-oxidant production in HUVEC probably through reduced expression of NADPH oxidase subunit gp91phox and p22phox, reduced membrane translocation ...
Dietary fats and dietary cholesterol and risk of stroke in women
24 January 2012
Susanna C. Larsson, Jarmo Virtamo, Alicja Wolk
Abstract: Background: Whether intakes of dietary fat and cholesterol are associated with risk of stroke remain unclear. We examined the associations between intakes of total fat, specific types of fat...
A phosphodiesterase 3 inhibitor, K-134, improves hindlimb skeletal muscle circulation in rat models of peripheral arterial disease
24 January 2012
Hideo Yoshida, Shinsuke Itoh, Takuya Hara, Yusuke Sasaki, Shoichi Kondo, Takashi Nakagawa, Akimune Asanuma, Sohei Tanabe
Highlights: ► K-134 increases hindlimb muscle blood flow in a rat femoral artery occlusion model. ► K-134 protects against adverse vascular remodeling in ischemic hindlimb muscles. ► K-134 prevents hi...
Functionality of postprandial larger HDL2 particles is enhanced following CETP inhibition therapy
24 January 2012
Natacha Bellanger, Zélie Julia, Elise F. Villard, Petra El Khoury, Emilie Duchene, M. John Chapman, Natalie Fournier, Wilfried Le Goff, Maryse Guerin
Highlights: ► CETP inhibition preferentially and selectively improves the capacity of large postprandial HDL2b subspecies to mediate cellular FC efflux. ► Postprandial HDL particles from patients trea...

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ESC/EAS Guidelines for the management of dyslipidaemias: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)
July 2011 (Vol. 217 | No. 1 | Pages 3-46)
Alberico L. Catapano, Željko Reiner, Guy De Backer, Ian Graham, Marja-Riitta Taskinen, Olov Wiklund, Stefan Agewall, Eduardo Alegria, M. John Chapman, Paul Durrington, Serap Erdine, Julian Halcox, Richard Hobbs, John Kjekshus, Pasquale Perrone Filardi, Gabriele Riccardi, Robert F. Storey, David Wood, Authors/Task Force Members: ESC Committee for Practice Guidelines (CPG) 2008–2010 and 2010–2012 Committees: Jeroen Bax (CPG Chairperson 2010–2012) (The Netherlands), Alec Vahanian (CPG Chairperson 2008–2010) (France), Angelo Auricchio (Switzerland), Helmut Baumgartner (Germany), Claudio Ceconi (Italy), Veronica Dean (France), Christi Deaton (UK), Robert Fagard (Belgium), Gerasimos Filippatos (Greece), Christian Funck-Brentano (France), David Hasdai (Israel), Richard Hobbs (UK), Arno Hoes (The Netherlands), Peter Kearney (Ireland), Juhani Knuuti (Finland), Philippe Kolh (Belgium), Theresa McDonagh (UK), Cyril Moulin (France), Don Poldermans (The Netherlands), Bogdan Popescu (Romania), Željko Reiner (Croatia), Udo Sechtem (Germany), Per Anton Sirnes (Norway), Michal Tendera (Poland), Adam Torbicki (Poland), Panos Vardas (Greece), Petr Widimsky (Czech Republic), Stephan Windecker (Switzerland)
Arterial endothelial function and wall thickness in familial hypercholesterolemia and familial combined hyperlipidemia and the effect of statins. A systematic review and meta-analysis
January 2011 (Vol. 214 | No. 1 | Pages 129-138)
Constantina Masoura, Christos Pitsavos, Konstantinos Aznaouridis, Ioannis Skoumas, Charalambos Vlachopoulos, Christodoulos Stefanadis
The three-gene paraoxonase family: Physiologic roles, actions and regulation
January 2011 (Vol. 214 | No. 1 | Pages 20-36)
Louis-Philippe Précourt, Devendra Amre, Marie-Claude Denis, Jean-Claude Lavoie, Edgard Delvin, Ernest Seidman, Emile Levy
Perivascular adipose tissue as a cause of atherosclerosis
January 2011 (Vol. 214 | No. 1 | Pages 3-10)
Sandra N. Verhagen, Frank L.J. Visseren
Appropriate use criteria for carotid intima media thickness testing
January 2011 (Vol. 214 | No. 1 | Pages 43-46)
The Society of Atherosclerosis Imaging and Prevention, Developed in collaboration with the International Atherosclerosis Society

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Atherosclerosis is published by Elsevier and is an official publication of European Atherosclerosis Society, International Atherosclerosis Society, and the Society of Atherosclerosis Imaging and Prevention.

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About Atherosclerosis

Atherosclerosis brings together from all sources papers concerned with research and investigation on atherosclerosis, its complications, and related diseases, including: lipoprotein metabolism, arterial and vascular biology and disease, thrombosis, inflammation, disorders of lipid transport, diabetes and hypertension as related to atherosclerosis, and cardiovascular risk factors. The editors are also interested in clinical papers dealing with case studies of specific or general interest, new or unusual lipid syndromes, and the genetic basis and familial incidence of atherosclerosis and related diseases. High quality reports of controlled clinical trials of drugs or diets will be considered provided the paper deals with the mechanism of action of the drug or diet.

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