Atherosclerosis
Volume 168, Issue 2 , Pages 255-262 , June 2003

Effects of vitamin supplementation and hyperhomocysteinemia on atherosclerosis in apoE-deficient mice

  • Ji Zhou

      Affiliations

    • Departments of Cardiology, Aarhus University Hospital (Skejby), Aarhus, Denmark
    • Corresponding Author InformationCorresponding author. Address: Henderson Research Centre, 711 Concession Street, Hamilton, Ont., Canada L8V 1C3. Tel.: +1-905-527-2299x43789; fax: +1-905-575-2646
  • ,
  • Jan Møller

      Affiliations

    • Departments of Clinical Biochemistry, Aarhus University Hospital (Skejby), Aarhus, Denmark
  • ,
  • Merel Ritskes-Hoitinga

      Affiliations

    • Biomedical Laboratory, University of Southern Denmark Odense, Denmark
  • ,
  • Mogen L Larsen

      Affiliations

    • Department of Cardiology, Aarhus University Hospital (Amtssygehuset), Aarhus, Denmark
  • ,
  • Richard C Austin

      Affiliations

    • Henderson Research Centre and McMaster University, Hamilton, Canada
  • ,
  • Erling Falk

      Affiliations

    • Departments of Cardiology, Aarhus University Hospital (Skejby), Aarhus, Denmark

Received 15 September 2002 ,Revised 28 February 2003 ,Accepted 7 March 2003.

References 

  1. Eikelboom JW, Lonn E, Genest J, Hankey G, Yusuf S. Homocyst(e)ine and cardiovascular disease: a critical review of the epidemiologic evidence. Ann. Intern. Med. 1999;131:363–375
  2. Zhou J, Moller J, Danielsen CC, Bentzon J, Ravn HB, Austin RC, et al.  Dietary supplementation with methionine and homocysteine promotes early atherosclerosis but not plaque rupture in ApoE-deficient mice. Arterioscler. Thromb. Vasc. Biol. 2001;21:1470–1476
  3. Hofmann MA, Lalla E, Lu Y, Gleason MR, Wolf BM, Tanji N, et al.  Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model. J. Clin. Invest. 2001;107:675–683
  4. Lentz SR. Does homocysteine promote atherosclerosis?. Arterioscler. Thromb. Vasc. Biol. 2001;21:1385–1386
  5. Selhub J, Jacques PF, Wilson PW, Rush D, Rosenberg IH. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. J. Am. Med. Assoc. 1993;270:2693–2698
  6. Robinson K, Arheart K, Refsum H, Brattstrom L, Boers G, Ueland P, et al.  Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease. European COMAC Group. Circulation. 1998;97:437–443
  7. Graham IM, Daly LE, Refsum HM, Robinson K, Brattstrom LE, Ueland PM, et al.  Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project. J. Am. Med. Assoc. 1997;277:1775–1781
  8. Verhoef P, Meleady R, Daly LE, Graham IM, Robinson K, Boers GH. Homocysteine, vitamin status and risk of vascular disease; effects of gender and menopausal status. European COMAC Group. Eur. Heart. J. 1999;20:1234–1244
  9. Ubbink JB, Vermaak WJ, van der Merwe A, Becker PJ, Delport R, Potgieter HC. Vitamin requirements for the treatment of hyperhomocysteinemia in humans. J. Nutr. 1994;124:1927–1933
  10. Rimm EB, Willett WC, Hu FB, Sampson L, Colditz GA, Manson JE, et al.  Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women. J. Am. Med. Assoc. 1998;279:359–364
  11. Yap S, Naughten ER, Wilcken B, Wilcken DE, Boers GH. Vascular complications of severe hyperhomocysteinemia in patients with homocystinuria due to cystathionine beta-synthase deficiency: effects of homocysteine-lowering therapy. Semin. Thromb. Hemost. 2000;26:335–340
  12. Bellamy MF, McDowell IF, Ramsey MW, Brownlee M, Newcombe RG, Lewis MJ. Oral folate enhances endothelial function in hyperhomocysteinaemic subjects. Eur. J. Clin. Invest. 1999;29:659–662
  13. Verhaar MC, Wever RM, Kastelein JJ, van Loon D, Milstien S, Koomans HA, et al.  Effects of oral folic acid supplementation on endothelial function in familial hypercholesterolemia. A randomized placebo-controlled trial. Circulation. 1999;100:335–338
  14. Verhaar MC, Rabelink TJ. Future for folates in cardiovascular disease. Eur. J. Clin. Invest. 1999;29:657–658
  15. Graham IM, O'Callaghan P. The role of folic acid in the prevention of cardiovascular disease. Curr. Opin. Lipidol. 2000;11:577–587
  16. Reeves PG, Nielsen FH, Fahey GC. AIN93 purified diets for laboratory rodents: final report of the American Institute of Nutrition Ad Hoc writing committee on the reformulation of the AIN76-A rodent diet. J. Nutr. 1993;123:1935–1951
  17. Møller J, Rasmussen K. Homocysteine in plasma: stabilization of blood samples with fluoride. Clin. Chem. 1995;41:758–759
  18. Paigen B, Morrow A, Holmes PA, Mitchell D, Williams RA. Quantitative assessment of atherosclerotic lesions in mice. Atherosclerosis. 1987;68:231–240
  19. Daugherty A, Pure E, Delfel-Butteiger D, Chen S, Leferovich J, Roselaar SE, et al.  The effects of total lymphocyte deficiency on the extent of atherosclerosis in apolipoprotein E−/− mice. J. Clin. Invest. 1997;100:1575–1580
  20. Bentzon JF, Skovenborg E, Hansen C, Moller J, de Gaulejac NS, Proch J, et al.  Red wine does not reduce mature atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2001;103:1681–1687
  21. National Research Council . Nutrient requirements of laboratory animals. 4th revised ed.. Washington, DC: National Academy Press; 1995;
  22. Lentz SR, Erger RA, Dayal S, Maeda N, Malinow MR, Heistad DD, et al.  Folate dependence of hyperhomocysteinemia and vascular dysfunction in cystathionine beta-synthase-deficient mice. Am. J. Physiol. Heart Circ. Physiol. 2000;279:H970–H975
  23. Werstuck GH, Lentz SR, Dayal S, Hossain GS, Sood SK, Shi YY, et al.  Homocysteine-induced endiplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways. J. Clin. Invest. 2001;107:1263–1273
  24. Starkebaum G, Harlan JM. Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine. J. Clin. Invest. 1986;77:1370–1376
  25. Loscalzo J. The oxidant stress of hyperhomocyst(e)inemia. J. Clin. Invest. 1996;98:5–7
  26. Eberhardt RT, Forgione MA, Cap A, Leopold JA, Rudd MA, Trolliet M, et al.  Endothelial cell dysfunction in a murine model of mild hyperhomocyst(e)inemia. J. Clin. Invest. 2000;106:483–491
  27. Jacobsen DW. Hyperhomocysteinemia and oxidative stress: time for a reality check?. Arterioscler. Thromb. Vasc. Biol. 2000;20:1182–1184
  28. Verhaar MC, Wever RM, Kastelein JJ, van Dam T, Koomans HA, Rabelink TJ. 5-Methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia. Circulation. 1998;97:237–241
  29. Verhaar MC, Stroes E, Rabelink TJ. Folates and cardiovascular disease. Arterioscler. Thromb. Vasc. Biol. 2002;22:6–13
  30. Nakashima Y, Plump AS, Raines EW, Breslow JL, Ross R. ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler. Thromb. 1994;14:133–140
  31. Reddick RL, Zhang SH, Maeda N. Atherosclerosis in mice lacking apoE. Evaluation of lesional development and progression. Arterioscler. Thromb. 1994;14:141–147
  32. Falk E, Fuster V. Atherogenesis and its determinants. In:  Fuster V,  Alexander RW,  O'Rourke RA,  Roberts R,  King SB,  Wellens HJJ editor. Hurst's the heart. 10th ed.. New York: McGraw-Hill; 2001; chapter 35
  33. Palinski W, Napoli C, Reaven PD. Mouse models of atherosclerosis. In:  Simon DI,  Rogers C editor. Vascular disease and injury: preclinical research. Totowa: Humana Press; 2001; chapter 12

PII: S0021-9150(03)00138-2

doi: 10.1016/S0021-9150(03)00138-2

Atherosclerosis
Volume 168, Issue 2 , Pages 255-262 , June 2003