Atherosclerosis
Volume 169, Issue 1 , Pages 121-130 , July 2003

Analysis of the apo(a) size polymorphism in Asian Indian populations: association with Lp(a) concentration and coronary heart disease

  • F.S. Geethanjali

      Affiliations

    • Institute of Medical Biology and Human Genetics, University of Innsbruck, 6020 Innsbruck, Austria
    • Contributed equally.
  • ,
  • Kalpana Luthra

      Affiliations

    • Institute of Medical Biology and Human Genetics, University of Innsbruck, 6020 Innsbruck, Austria
    • Contributed equally.
  • ,
  • Arno Lingenhel

      Affiliations

    • Institute of Medical Biology and Human Genetics, University of Innsbruck, 6020 Innsbruck, Austria
  • ,
  • A.S. Kanagasaba-Pathy

      Affiliations

    • Department of Clinical Biochemistry, Christian Medical College and Hospital, Vellore, Tamil Nadu, India
  • ,
  • Jose Jacob

      Affiliations

    • Department of Cardiology, CMC Hospital, Vellore, Tamil Nadu, India
  • ,
  • Lalit M. Srivastava

      Affiliations

    • All India Institute of Medical Science, New Delhi, India
  • ,
  • Suman Vasisht

      Affiliations

    • All India Institute of Medical Science, New Delhi, India
  • ,
  • Hans-Georg Kraft

      Affiliations

    • Institute of Medical Biology and Human Genetics, University of Innsbruck, 6020 Innsbruck, Austria
  • ,
  • Gerd Utermann

      Affiliations

    • Institute of Medical Biology and Human Genetics, University of Innsbruck, 6020 Innsbruck, Austria
    • Corresponding Author InformationCorresponding author

Received 20 July 2002 ,Revised 14 March 2003 ,Accepted 3 April 2003.

References 

  1. Murray CJ, Lopez AD. Mortality by cause for eight regions of the world: global burden of disease study. Lancet. 1997;349:1269–1276
  2. Murray CJ, Lopez AD. Alternative projections of mortality and disability by cause 1990–2020: global burden of disease study. Lancet. 1997;349:1498–1504
  3. Vasisht S, Gulati R, Srivastava LM, et al.  Apolipoprotein(a) polymorphism and its association with plasma lipoprotein(a) levels: a North Indian study. Indian Heart J. 2000;52:165–170
  4. Christopher R, Kailasanatha KM, Nagaraja D, Tripathi M. Case–control study of serum lipoprotein(a) and apolipoproteins A-I and B in stroke in the young. Acta Neurol. Scand. 1996;94:127–130
  5. Boerwinkle E, Leffert CC, Lin J, Lackner C, Chiesa G, Hobbs HH. Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations. J. Clin. Invest. 1992;90:52–60
  6. Kraft HG, Köchl S, Menzel HJ, Sandholzer C, Utermann G. The apolipoprotein(a) gene: a transcribed hypervariable locus controlling plasma lipoprotein(a) concentration. Hum. Genet. 1992;90:220–230
  7. Mooser V, Scheer D, Marcovina SM, et al.  The apo(a) gene is the major determinant of variation in plasma Lp(a) levels in African Americans. Am. J. Hum. Genet. 1997;61:402–417
  8. Scholz M, Kraft HG, Lingenhel A, et al.  Genetic control of lipoprotein(a) concentrations is different in Africans and Caucasians. Eur. J. Hum. Genet. 1999;7:169–178
  9. Utermann G. Genetic architecture and evolution of the lipoprotein(a) trait. Curr. Opin. Lipidol. 1999;10:133–141
  10. Utermann G. Lipoprotein(a). In:  Scriver CR,  Beaudet AL,  Sly WS,  Valle D editor. The metabolic bases of inherited disease. New York: McGrawHill; 2001;p. 2753–2787
  11. DeMeester CA, Bu X, Gray RJ, Lusis AJ, Rotter JI. Genetic variation in lipoprotein(a) levels in families enriched for coronary artery disease is determined almost entirely by the apolipoprotein(a) gene locus. Am. J. Hum. Genet. 1995;56:287–293
  12. Kraft HG, Lingenhel A, Kochl S, et al.  Apolipoprotein(a) kringle IV repeat number predicts risk for coronary heart disease. Arterioscler. Thromb. Vasc. Biol. 1996;16:713–719
  13. Wild SH, Fortmann SP, Marcovina SM. A prospective case–control study of lipoprotein(a) levels and apo(a) size and risk of coronary heart disease in Stanford Five-City Project participants. Arterioscler. Thromb. Vasc. Biol. 1997;17:239–245
  14. Linden T, Taddei-Peters W, Wilhelmsen L, et al.  Serum lipids, lipoprotein(a) and apo(a) isoforms in patients with established coronary artery disease and their relation to disease and prognosis after coronary by-pass surgery. Atherosclerosis. 1998;137:175–186
  15. Klausen IC, Sjol A, Hansen PS, et al.  Apolipoprotein(a) isoforms and coronary heart disease in men: a nested case–control study. Atherosclerosis. 1997;132:77–84
  16. Brazier L, Tiret L, Luc G, et al.  Sequence polymorphisms in the apolipoprotein(a) gene and their association with lipoprotein(a) levels and myocardial infarction. The ECTIM study. Atherosclerosis. 1999;144:323
  17. Marcovina SM, Albers JJ, Wijsman E, Zhang Z, Chapman NH, Kennedy H. Differences in Lp[a] concentrations and apo[a] polymorphs between black and white Americans. J. Lipid Res. 1996;37:2569–2585
  18. Paultre F, Pearson TA, Weil HF, et al.  High levels of Lp(a) with a small apo(a) isoform are associated with coronary artery disease in African American and white men. Arterioscler. Thromb. Vasc. Biol. 2000;20:2619–2624
  19. Menzel H-J, Dieplinger H, Lackner C, et al.  Abetalipoproteinemia with an ApoB-100-lipoprotein(a) glycoprotein complex in plasma. Indication for an assembly defect. J. Biol. Chem. 1990;265:981–986
  20. Kraft HG, Lingenhel A, Bader G, Kostner GM, Utermann G. The relative electrophoretic mobility of apo(a) isoforms depends on the gel system: proposal of a nomenclature for apo(a) phenotypes. Atherosclerosis. 1996;125:53–61
  21. Kraft HG, Lingenhel A, Pang RWC, et al.  Frequency distributions of apolipoprotein(a) kringle IV repeat alleles and their effects on lipoprotein(a) levels in Caucasian, Asian, and African populations: the distribution of null alleles is non-random. Eur. J. Hum. Genet. 1996;4:74–87
  22. Pinto RJ. Risk factors for coronary heart disease in Asian Indians: clinical implications for prevention of coronary heart disease. Indian J. Med. Sci. 1998;52:49–54
  23. Enas EA, Dhawan J, Petkar S. Coronary artery disease in Asian Indians: lessons learnt and the role of lipoprotein(a). Indian Heart J. 1997;49:25–34
  24. Dhawan J. Coronary heart disease risks in Asian Indians. Curr. Opin. Lipidol. 1996;7:196–198
  25. Hughes K, Aw TC, Kuperan P, Choo M. Central obesity, insulin resistance, syndrome X, lipoprotein(a), and cardiovascular risk in Indians, Malays, and Chinese in Singapore. J. Epidemiol. Community Health. 1997;51:394–399
  26. Gazzaruso C, Geroldi D, Garzanti A, et al.  Apolipoprotein(a) phenotypes as genetic markers of coronary atherosclerosis severity. Int. J. Cardiol. 1998;64:277–284
  27. Ogorelkova M, Kraft HG, Ehnholm C, Utermann G. Single nucleotide polymorphisms in exons of the apo(a) kringles IV types 6 to 10 domain affect Lp(a) plasma concentrations and have different patterns in Africans and Caucasians. Hum. Mol. Genet. 2001;10:815–824
  28. Amemiya H, Arinami T, Kikuchi S, et al.  Apolipoprotein(a) size and pentanucleotide repeat polymorphisms are associated with the degree of atherosclerosis in coronary heart disease. Atherosclerosis. 1996;123:181
  29. Gazzaruso C, Garzanti A, Buscaglia P, et al.  Association between apolipoprotein(a) phenotypes and coronary heart disease at a young age. J. Am. Coll. Cardiol. 1999;33:157–163
  30. Sandholzer C, Saha N, Kark JD, et al.  Apo(a) isoforms predict risk for coronary heart disease: a study in six populations. Arterioscler. Thromb. 1992;12:1214–1226
  31. Hoogeveen RC, Gambhir JK, Gambhir DS, et al.  Evaluation of Lp[a] and other independent risk factors for CHD in Asian Indians and their USA counterparts. J. Lipid Res. 2001;42:631–638
  32. Bhatnagar D, Anand IS, Durrington PN, et al.  Coronary risk factors in people from the Indian subcontinent living in West London and their siblings in India. Lancet. 1995;345:405–409
  33. Ober C, Abney M, McPeek MS. The genetic dissection of complex traits in a founder population. Am. J. Hum. Genet. 2001;69:1068–1079
  34. Broeckel U, Hengstenberg C, Mayer B, et al.  A comprehensive linkage analysis for myocardial infarction and its related risk factors. Nat. Genet. 2002;30:210–214
  35. Moliterno DJ, Jokinen EV, Miserez AR, et al.  No association between plasma lipoprotein(a) concentrations and the presence or absence of coronary atherosclerosis in African–Americans. Arterioscler. Thromb. 1995;15:850–855

PII: S0021-9150(03)00143-6

doi: 10.1016/S0021-9150(03)00143-6

Atherosclerosis
Volume 169, Issue 1 , Pages 121-130 , July 2003