Atherosclerosis
Volume 168, Issue 2 , Pages 271-282 , June 2003

Degree of oxidation of low density lipoprotein affects expression of CD36 and PPARγ, but not cytokine production, by human monocyte-macrophages

  • Ian C. Kavanagh

      Affiliations

    • School of Food Biosciences, The University of Reading, Whiteknights PO Box 226, Reading RG6 6AP, UK
    • ,
  • Carole E. Symes

      Affiliations

    • School of Food Biosciences, The University of Reading, Whiteknights PO Box 226, Reading RG6 6AP, UK
    • ,
  • Pauline Renaudin

      Affiliations

    • School of Food Biosciences, The University of Reading, Whiteknights PO Box 226, Reading RG6 6AP, UK
    • ,
  • Esther Nova

      Affiliations

    • School of Food Biosciences, The University of Reading, Whiteknights PO Box 226, Reading RG6 6AP, UK
    • ,
  • Maria Dolores Mesa

      Affiliations

    • School of Food Biosciences, The University of Reading, Whiteknights PO Box 226, Reading RG6 6AP, UK
    • ,
  • George Boukouvalas

      Affiliations

    • School of Food Biosciences, The University of Reading, Whiteknights PO Box 226, Reading RG6 6AP, UK
    • ,
  • David S. Leake

      Affiliations

    • School of Animal and Microbial Sciences, The University of Reading, Whiteknights PO Box 226, Reading RG6 6AP, UK
    • ,
  • Parveen Yaqoob

      Affiliations

    • School of Food Biosciences, The University of Reading, Whiteknights PO Box 226, Reading RG6 6AP, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44-118-378-8720; fax: +44-118-378-0080

Received 21 November 2002 ,Revised 3 March 2003 ,Accepted 31 March 2003.

References 

  1. Febbraio M, Podrez EA, Smith JD, et al.  Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice. J. Clin. Invest. 2000;105:1049–1056
  2. Huh HY, Pearce SF, Yesner LM, Schindler JL, Silverstein RL. Regulated expression of CD36 during monocyte-to-macrophage differentiation: potential role of CD36 in foam cell formation. Blood. 1996;87:2020–2028
  3. Nagy L, Tontonoz P, Alvarez JGA, Chen H, Evans RM. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARγ. Cell. 1998;93:229–240
  4. Tontonoz P, Nagy L, Alvarez JGA, Thomazy VA, Evans RM. PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell. 1998;93:241–252
  5. Ricote M, Li AC, Wilson TM, Kelly CJ, Glass CK. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage function. Nature. 1998;391:79–82
  6. Chawla A, Barak Y, Nagy L, Liao D, Tontonoz P, Evans RM. PPARγ dependent and independent effects on macrophage gene expression in lipid metabolism and inflammation. Nat. Med. 2001;7:48–52
  7. Chinetti G, Lestavel S, Bocher V, et al.  PPARα and PPARγ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. Nat. Med. 2001;7:53–58
  8. Patel L, Charlton SJ, Marshall IC, et al.  PPARγ is not a critical mediator of primary monocyte differentiation or foam cell formation. Biochem. Biophys. Res. Commun. 2002;290:707–712
  9. Jiang C, Ting AT, Seed B. PPARγ agonists inhibit production of monocyte inflammatory cytokines. Nature. 1998;391:82–86
  10. Thieringer R, Fenyk-Melody JE, Le Grand CB, et al.  Activation of peroxisome proliferator-activated receptor γ does not inhibit IL-6 or TNFα responses of macrophages to lipopolysaccharide in vitro or in vivo. J. Immunol. 2000;164:1046–1054
  11. Vaidya S, Somers EP, Wright SD, Detmers PA, Bansal VS. 15-Deoxy prostaglandin J2 inhibits the β2 integrin-dependent oxidative burst: involvement of a mechanism distinct from peroxisome proliferator-activated receptor-γ ligation. J. Immunol. 1999;163:6187–6192
  12. Ross R. Mechanisms of disease—atherosclerosis—an inflammatory disease. New Engl. J. Med. 1999;340:115–126
  13. Berliner JA, Territo MC, Sevanian A, et al.  Minimally modified low density lipoprotein stimulates monocyte endothelial interactions. J. Clin. Invest. 1990;85:1260–1266
  14. Hamilton TA, Major JA, Chisolm GM. The effects of oxidized low density lipoproteins on inducible mouse macrophage gene expression are gene and stimulus dependent. J. Clin. Invest. 1995;95:2020–2027
  15. Brand K, Banka CL, Mackman N, Terkeltaub RA, Fan S-T, Curtiss LK. Oxidized LDL enhances lipopolysaccharide-induced tissue factor expression in human adherent monocytes. Arterioscler. Thromb. Vasc. Biol. 1994;14:790–797
  16. Hamilton TA, Ma G, Chisolm GM. Oxidized low-density lipoprotein suppresses the expression of tumor necrosis factor-alpha mRNA in stimulated murine peritoneal macrophages. J. Immunol. 1990;144:2343–2350
  17. Mikita T, Porter G, Lawn RM, Shiffman D. Oxidized low density lipoprotein exposure alters the transcriptional response of macrophages to inflammatory stimulus. J. Biol. Chem. 2001;276:45729–45739
  18. Glass CK, Witzum JL. Atherosclerosis: the road ahead. Cell. 2001;104:503–516
  19. Rice-Evans C, Leake DS, Bruckdorfer KR, Diplock AT. Practical approaches to low density lipoprotein oxidation—whys wherefores and pitfalls. Free Radic. Res. 1996;25:285–311
  20. Yoshida H, Quehenberger O, Kondratenko N, Green S, Steinberg D. Minimally oxidized low-density lipoprotein increases expression of the scavenger receptor A, CD36 and macrosialin in resident mouse peritoneal macrophages. Arterioscler. Thromb. Vasc. Biol. 1998;18:794–802
  21. Siow RCM, Richards JP, Pedley KC, Leake DS, Mann G. Vitamin C protects human vascular smooth muscle cells against apoptosis by moderately oxidized LDL containing high levels of lipid hydroperoxides. Arterioscler. Thromb. Vasc. Biol. 1999;19:2387–2394
  22. Gomez-Munoz A, Martens JS, Steinbrecher UP. Stimulation of phospholipase D activity by oxidized LDL in mouse peritoneal macrophages. Arterioscler. Thromb. Vasc. Biol. 2000;20:135–143
  23. El-Saadani M, Esterbauer H, El-Sayed M, Gohe M, Nassar AY, Jurgens G. A spectrophotometric assay for lipid peroxides in serum lipoproteins using a commercially available reagent. J. Lipid Res. 1989;30:627–630
  24. Borenfreund E, Babich H, Martinalguacil N. Rapid chemosensitivity assay with human normal and tumor cells in vitro. In Vitro Cell Dev. Biol. 1990;20:1030–1034
  25. Watson AD, Leitinger N, Navab M, et al.  Structural identification by mass spectrometry of oxidized phospholipids in minimally oxidized low density lipoprotein that induce monocyte/endothelial interactions and evidence for their presence in vivo. J. Biol. Chem. 1997;272:13597–13607
  26. Leitinger N, Tyner TR, Oslund L, et al.  Structurally similar oxidized phospholipids differentially regulate endothelial binding of monocytes and neutrophils. Proc. Natl. Acad. Sci. USA. 1999;96:12010–12015
  27. Subbanagounder G, Leitinger N, Schwenke DC, et al.  Determinants of bioactivity of oxidized phospholipids-specific oxidized fatty acyl groups at the sn-2 position. Arterioscler. Thromb. Vasc. Biol. 2000;20:2248–2254
  28. Carpenter KH, Wilkins GM, Fussell B, Ballantine JA, Taylor SE, Mitchinson MJ, et al. Production of oxidized lipids during modification of low-density lipoprotein by macrophages or copper. Biochem. J. 1994;304:625–633
  29. Dominaitiene R, Lindgren S, Janciauskiene S. Effects of differentially oxidized LDL on the expression of pro-inflammatory molecules in human monocytes in vitro. In Vitro Molec. Toxicol. 2001;14:83–97
  30. Wang T, Yu W-G, Powell WS. Formation of monohydroxy derivatives of arachidonic acid, linoleic acid and oleic acid during oxidation of low density lipoprotein by copper ions and endothelial cells. J. Lipid Res. 1992;33:525–537
  31. Fajas L, Auboeuf D, Raspe E, et al.  The organization, promoter analysis and expression of the human PPARγ gene. J. Biol. Chem. 1997;272:18779–18789
  32. Chung SW, Kang BY, Kim SY, Pak YK, Cho D, Trincheri G, et al. Oxidized low-density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor gamma and nuclear factor kappa B. J. Biol. Chem. 2000;275:32681–32687
  33. Sato O, Kuriki C, Fukui Y, Motojima K. Dual promoter structure of mouse and human fatty acid translocase/CD36 genes and unique transcriptional activation by peroxisome proliferator-activated receptor α and γ ligands. J. Biol. Chem. 2002;277:15703–15711
  34. Stengel D, Antonucci M, Arborati M, Hourton D, Griglio S, Chapman MJ, et al. Expression of PAF receptor in human monocyte-derived macrophages is down-regulated by oxidized LDL. Arterioscler. Thromb. Vasc. Biol. 1997;17:954–962
  35. Hourton D, Delerive P, Stankova J, Staels B, Chapman AJ, Ninio E. Oxidized low-density lipoprotein and peroxisome-proliferator-activated receptor α down-regulate platelet-activating factor receptor expression in human macrophages. Biochem. J. 2001;354:225–232
  36. Marx N, Sukhova G, Murphy C, Libby P, Plutzky J. Macrophages in human atheroma contain PPARγ. Differentiation-dependent peroxisomal proliferator-activated receptor γ expression and reduction of MMP-9 activity through PPARγ activation in mononuclear phagocytes in vitro. Am. J. Pathol. 1998;153:17–23
  37. Caspar-Baugil S, Tkaczuk J, Haure M-J, et al.  Mildly oxidized low-density lipoproteins decrease early production of interleukin-2 and nuclear factor kB binding to DNA in activated T-lymphocytes. Biochem. J. 1999;337:269–274
  38. Alcouffe J, Caspar-Bauguil S, Garcia V, Salvayre R, Thomsen M, Benoist H. Oxidized low density lipoproteins induce apoptosis in PHA-activated peripheral blood mononuclear cells and in the Jurkat cell line. J. Lipid Res. 1999;40:1200–1210

PII: S0021-9150(03)00148-5

doi: 10.1016/S0021-9150(03)00148-5

Atherosclerosis
Volume 168, Issue 2 , Pages 271-282 , June 2003

Article Tools

* Image Usage & Resolution