Atherosclerosis
Volume 168, Issue 2 , Pages 389-396 , June 2003

Haptoglobin elutes from human atherosclerotic coronary arteries—a potential marker of arterial pathology

  • Maria A. Matuszek

      Affiliations

    • The Heart Research Institute, Sydney, Australia
    • ,
  • Lina P Aristoteli

      Affiliations

    • The Heart Research Institute, Sydney, Australia
    • ,
  • Paul G. Bannon

      Affiliations

    • The Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia
    • ,
  • Paul N. Hendel

      Affiliations

    • The Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia
    • ,
  • Clifford F. Hughes

      Affiliations

    • The Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia
    • ,
  • Wendy Jessup

      Affiliations

    • The Centre for Thrombosis and Vascular Research, University of New South Wales, Sydney, NSW 2052, Australia
    • ,
  • Roger T. Dean

      Affiliations

    • University of Canberra, ACT, Canberra, Australia
    • ,
  • Leonard Kritharides

      Affiliations

    • The Heart Research Institute, Sydney, Australia
    • The Centre for Thrombosis and Vascular Research, University of New South Wales, Sydney, NSW 2052, Australia
    • The Department of Cardiology, Concord Hospital, University of Sydney, Sydney, Australia
    • Corresponding Author InformationCorresponding author. Tel.: +61-2-9385-1179; fax: +61-2-9385-1389

Received 27 June 2002 ,Revised 3 March 2003 ,Accepted 8 April 2003.

References 

  1. Ridker PM. Inflammation, atherosclerosis, and cardiovascular risk: an epidemiologic view. Blood Coagul. Fibrinolysis. 1999;10(suppl 1):S9–12
  2. Lijana RC, Williams MC. Tetramethylbenzidine—a substitute for benzidine in hemoglobin analysis. J. Lab. Clin. Med. 1979;94:266–276
  3. Standefer JC, Vanderjagt D. Use of tetramethylbenzidine in plasma hemoglobin assay. Clin. Chem. 1977;23:749–751
  4. Morrissey JH. Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity. Anal. Biochem. 1981;117:307–310
  5. Rees D, Sloane T, Jessup W, Dean RT, Kritharides L. Apolipoprotein A-I stimulates secretion of apolipoprotein E by foam cell macrophages. J. Biol. Chem. 1999;274:27925–27933
  6. Langlois MR, Delanghe JR. Biological and clinical significance of haptoglobin polymorphism in humans. Clin. Chem. 1996;42:1589–1600
  7. Alekseeva IN. Acute phase blood proteins: role in the homeostasis and their synthesis induction in the liver. Fiziol. Zh. 1994;40:106–117
  8. Enger R. Acute-phase proteins in inflammation. C R Seances Soc. Biol. Fil. 1995;189:563–578
  9. Dobryszycka W. Biological functions of haptoglobin—new pieces to an old puzzle. Eur. J. Clin. Chem. Clin. Biochem. 1997;35:647–654
  10. Turner GA. Haptoglobin. A potential reporter molecule for glycosylation changes in disease. Adv. Exp. Med. Biol. 1995;376:231–238
  11. Braeckman L, De Bacquer D, Delanghe J, Claeys L, De Backer G. Associations between haptoglobin polymorphism, lipids, lipoproteins and inflammatory variables. Atherosclerosis. 1999;143:383–388
  12. Delanghe J, Cambier B, Langlois M, et al.  Haptoglobin polymorphism, a genetic risk factor in coronary artery bypass surgery. Atherosclerosis. 1997;132:215–219
  13. Stastny J, Fosslien E, Robertson AL. Human aortic intima protein composition during initial stages of atherogenesis. Atherosclerosis. 1986;60:131–139
  14. Stastny JJ, Fosslien E. Quantitative alteration of some aortic intima proteins in fatty streaks and fibro-fatty lesions. Exp. Mol. Pathol. 1992;57:205–214
  15. Smeets M, Klein DPVD, Poppen M, Lim SK, Pasterkamp G. The acute phase protein haptoglobin is a matrix metalloproteinase-2 inhibitor. Circulation. 2000;102(II):173

PII: S0021-9150(03)00150-3

doi: 10.1016/S0021-9150(03)00150-3

Atherosclerosis
Volume 168, Issue 2 , Pages 389-396 , June 2003

Article Tools

* Image Usage & Resolution