Atherosclerosis
Volume 176, Issue 1 , Pages 101-110 , September 2004

Emergence of dendritic cells in rupture-prone regions of vulnerable carotid plaques

  • Atilla Yilmaz

      Affiliations

    • Medical Clinic II, University of Erlangen-Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 9131 853 5301; fax: +49 9131 853 2079.
  • ,
  • Marlene Lochno

      Affiliations

    • Medical Clinic II, University of Erlangen-Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
  • ,
  • Friedemann Traeg

      Affiliations

    • Medical Clinic II, University of Erlangen-Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
  • ,
  • Iwona Cicha

      Affiliations

    • Medical Clinic II, University of Erlangen-Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
  • ,
  • Christine Reiss

      Affiliations

    • Medical Clinic II, University of Erlangen-Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
  • ,
  • Christian Stumpf

      Affiliations

    • Medical Clinic II, University of Erlangen-Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
  • ,
  • Dorette Raaz

      Affiliations

    • Medical Clinic II, University of Erlangen-Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
  • ,
  • Thomas Anger

      Affiliations

    • Medical Clinic II, University of Erlangen-Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
  • ,
  • Kerstin Amann

      Affiliations

    • Department of Pathology, University of Erlangen-Nuremberg, Hartmannstraβe 4, 91052 Erlangen, Germany
  • ,
  • Thomas Probst

      Affiliations

    • Department of Vascular Surgery, Clinic Nuremberg, Breslauer Straβe 201, 90340 Nuremberg, Germany
  • ,
  • Josef Ludwig

      Affiliations

    • Medical Clinic II, University of Erlangen-Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
  • ,
  • Werner G Daniel

      Affiliations

    • Medical Clinic II, University of Erlangen-Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
  • ,
  • Christoph D Garlichs

      Affiliations

    • Medical Clinic II, University of Erlangen-Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany

Received 19 December 2003 ,Revised 25 March 2004 ,Accepted 20 April 2004.

References 

  1. Hansson GK, Libby P, Schonbeck U, Yan ZQ. Innate and adaptive immunity in the pathogenesis of atherosclerosis. Circ Res. 2002;91:281–291
  2. Van der Wal AC, Becker AE. Atherosclerotic plaque rupture-pathologic basis of plaque stability and instability. Cardiovasc Res. 1999;41:334–344
  3. Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2000;20:1262–1275
  4. Ross R. Atherosclerosis is an inflammatory disease. Am Heart J. 1999;138:S419–420
  5. Kaartinen M, van der Wal AC, van der Loos CM, et al.  Mast cell infiltration in acute coronary syndromes: implications for plaque rupture. J Am Coll Cardiol. 1998;32:606–612
  6. Johnson JL, Jackson CL, Angelini GD, George SJ. Activation of matrix-degrading metalloproteinases by mast cell proteases in atherosclerotic plaques. Arterioscler Thromb Vasc Biol. 1998;18:1707–1715
  7. Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu YJ. Immunobiology of dendritic cells. Annu Rev Immunol. 2000;18:67–811
  8. Hart DN. Dendritic cells: unique leukocyte populations which control the primary immune response. Blood. 1997;90:3245–3287
  9. Bobryshev YV, Lord RS. S-100 positive cells in human arterial intima and in atherosclerotic lesions. Cardiovasc Res. 1995;29:689–696
  10. Bobryshev YV, Lord RS. Mapping of vascular dendritic cells in atherosclerotic arteries suggests their involvement in local immune-inflammatory reactions. Cardiovasc Res. 1998;37:799–810
  11. Cherian SM, Bobryshev YV, Liang H, et al.  Immunohistochemical and ultrastructural evidence that dendritic cells infiltrate stenotic aortocoronary saphenous vein bypass grafts. Cardiovasc Surg. 2001;9:194–200
  12. Bobryshev YV, Lord RS. Ultrastructural recognition of cells with dendritic cell morphology in human aortic intima. Contacting interactions of vascular dendritic cells in athero-resistant and athero-prone areas of the normal aorta. Arch Histol Cytol. 1995;58:307–322
  13. Bobryshev YV, Lord RS. Structural heterogeneity and contacting interactions of vascular dendritic cells in early atherosclerotic lesions of the human aorta. J Submicrosc Cytol Pathol. 1996;28:49–60
  14. Bobryshev YV, Watanabe T. Ultrastructural evidence for association of vascular dendritic cells with T-lymphocytes and with B-cells in human atherosclerosis. J Submicrosc Cytol Pathol. 1997;29:209–221
  15. Millonig G, Niederegger H, Rabl W, et al.  Network of vascular-associated dendritic cells in intima of healthy young individuals. Arterioscler Thromb Vasc Biol. 2001;21:503–508
  16. Salonen JT, Yla-Herttuala S, Yamamoto R, et al.  Autoantibody against oxidised LDL and progression of carotid atherosclerosis. Lancet. 1992;339:883–887
  17. Stemme S, Faber B, Holm J, Wiklund O, Witztum JL, Hansson GK. T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein. Proc Natl Acad Sci USA. 1995;92:3893–3897
  18. Alderman CJ, Bunyard PR, Chain BM, Foreman JC, Leake DS, Katz DR. Effects of oxidised low density lipoprotein on dendritic cells: a possible immunoregulatory component of the atherogenic micro-environment?. Cardiovasc Res. 2002;55:806–819
  19. Coutant F, Perrin-Cocon L, Agaugue S, Delair T, Andre P, Lotteau V. Mature dendritic cell generation promoted by lysophosphatidylcholine. J Immunol. 2002;169:1688–1695
  20. Naghavi M, Libby P, Falk E, et al.  From vulnerable plaque to vulnerable patient—a call for new definitions and risk assessment strategies: part I. Circulation. 2003;108:1664–1672
  21. Mosialos G, Birkenbach M, Ayehunie S, et al.  Circulating human dendritic cells differentially express high levels of a 55-kd actin-bundling protein. Am J Pathol. 1996;148:593–600
  22. Zhou LJ, Schwarting R, Smith HM, Tedder TF. A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily. J Immunol. 1992;149:735–742
  23. Saint-Vis B, Vincent J, Vandenabeele S, et al.  A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment. Immunity. 1998;9:325–336
  24. Erber WN, Willis JI, Hoffman GJ. An enhanced immunocytochemical method for staining bone marrow trephine sections. J Clin Pathol. 1997;50:389–393
  25. Bobryshev YV, Lord RS. Expression of heat shock protein-70 by dendritic cells in the arterial intima and its potential significance in atherogenesis. J Vasc Surg. 2002;35:368–375
  26. Van der Wal AC, Becker AE, van der Loos CM, Das PK. Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation. 1994;89:36–44
  27. Weis M, Schlichting CL, Engleman EG, Cooke JP. Endothelial determinants of dendritic cell adhesion and migration: new implications for vascular diseases. Arterioscler Thromb Vasc Biol. 2002;22:1817–1823
  28. Lutz MB, Schuler G. Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?. Trends Immunol. 2002;23:445–449
  29. Meuwissen M, van der Wal AC, Koch KT, et al.  Association between complex coronary artery stenosis and unstable angina and the extent of plaque inflammation. Am J Med. 2003;114:521–527
  30. Crisby M, Nordin-Fredriksson G, Shah PK, Yano J, Zhu J, Nilsson J. Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases, and cell death in human carotid plaques: implications for plaque stabilization. Circulation. 2001;103:926–933
  31. Pasterkamp G, Schoneveld AH, van der Wal AC, et al.  Inflammation of the atherosclerotic cap and shoulder of the plaque is a common and locally observed feature in unruptured plaques of femoral and coronary arteries. Arterioscler Thromb Vasc Biol. 1999;19:54–58

PII: S0021-9150(04)00217-5

doi: 10.1016/j.atherosclerosis.2004.04.027

Atherosclerosis
Volume 176, Issue 1 , Pages 101-110 , September 2004