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Atherosclerosis
Volume 182, Issue 1
, Pages 37-45
, September 2005
Common polymorphisms in the CYP7A1 gene do not contribute to variation in rates of bile acid synthesis and plasma LDL cholesterol concentration
References
- . Bile acid biosynthesis. Biochemistry. 1992;31:4737–4749
- . Cloning and regulation of cholesterol 7α-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis. J Biol Chem. 1990;265:8190–8197
- . Contribution of cholesterol 7α-hydroxylase to the regulation of lipoprotein metabolism. Curr Opin Lipidol. 1999;10:303–307
- . On the possible use of the serum level of 7 alpha-hydroxycholesterol as a marker for increased activity of the cholesterol 7 alpha-hydroxylase in humans. J Lipid Res. 1987;28:889–894
- . Bile acid synthesis in humans: regulation of hepatic microsomal cholesterol 7 alpha-hydroxylase activity. Gastroenterology. 1989;97:1498–1505
- . Colestipol and cholestyramine resin. Comparative effects in familial type II hyperlipoproteinemia. JAMA. 1972;222:676–681
- Effectiveness of low-dose colestipol therapy in patients with moderate hypercholesterolemia. Am J Cardiol. 1992;70:135–140
- . Adenovirus-mediated transfer of a gene encoding cholesterol 7α-hydroxylase into hamsters increases hepatic enzyme activity and reduces plasma total and low density lipoprotein cholesterol. J Clin Invest. 1995;96:700–709
- . Overexpression of cholesterol 7α-hydroxylase (CYP7A) in mice lacking the low density lipoprotein (LDL) receptor gene. J Biol Chem. 1997;273:126–132
- . Linkage between cholesterol 7α-hydroxylase and high plasma low-density lipoprotein cholesterol concentrations. J Clin Invest. 1998;101:1283–1291
- . Circulating markers for biosynthesis of cholesterol and bile acids are not depressed in asymptomatic gallstone subjects. J Hepatol. 1997;27:150–155
- . The plasma level of 7alpha-hydroxy-4-cholesten-3-one reflects the activity of hepatic cholesterol 7 alpha-hydroxylase in man. FEBS Lett. 1991;284:216–218
- . Serum concentrations of 7 alpha-hydroxy-4-cholesten-3-one reflect bile acid synthesis in humans. Hepatology. 1996;24:123–126
- . Biliary lipid output and bile acid kinetics in cholesterol gallstone disease; evidence for an increased hepatic secretion of cholesterol in Swedish patients. Gastroenterology. 1985;89:287–293
- . Relation of plasma levels and composition of apolipoprotein B-containing lipoproteins to angiographically defined coronary artery disease in young patients with myocardial infarction. Circulation. 1993;88:2180–2189
- . Apolipoprotein E*3-Leiden allele results from a partial gene duplication in exon 4. Biochem Biophys Res Commun. 1989;165:851–857
- . Cholesterol 7α-hydroxylase promoter separated from cyclophilin pseudogene by Alu sequence. Biochim Biophys Acta. 1993;1168:239–242
- . Structure and nucleotide sequences of the human cholesterol 7α-hydroxylase gene (CYP7). Genomics. 1994;20:320–323
- . Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons. Mol Cell Biol. 1991;11:182–191
- High level expression of functional full length and truncated glucocorticoid receptor in Chinese hamster ovary cells. J Biol Chem. 1991;266:10078–10085
- . A new spectrophotometric assay for protein in cell extracts. Anal Biochem. 1977;82:362–371
- . The two allele sequences of a common polymorphism in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene respond differently to interleukin-1 in HepG2 cells. J Biol Chem. 1993;268:10739–10745
- Cloning of the human cholesterol 7 alpha-hydroxylase (CYP7) and localization to chromosome 8q11-q12. Genomics. 1992;14:153–161
- . Characterization of hepatic-specific regulatory elements in the promoter region of the human cholesterol 7α-hydroxylase gene. J Biol Chem. 1997;272:3444–3452
- . Association of the A-204C polymorphism in the cholesterol 7α-hydroxylase gene with variations in plasma low density lipoprotein cholesterol levels in the Framingham Offspring Study. J Lipid Res. 1999;40:1883–1889
- Increase of deoxycholate in supersaturated bile of patients with gallstone disease and its correlation with de novo synthesis of cholesterol and bile acids in liver, gallbladder emptying, and small intestine transit. Hepatology. 1995;21:1291–1302
- Human cholesterol 7α-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype. J Clin Invest. 2003;110:109–117
PII: S0021-9150(05)00107-3
doi: 10.1016/j.atherosclerosis.2005.01.032
© 2005 Elsevier Ireland Ltd. All rights reserved.
« Previous
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Atherosclerosis
Volume 182, Issue 1
, Pages 37-45
, September 2005
