Atherosclerosis
Volume 183, Issue 1 , Pages 57-63 , November 2005

A functional role for inducible costimulator (ICOS) in atherosclerosis

  • Arnon Afek

      Affiliations

    • Department of Cardiology and the Cardiovascular Research Laboratory, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, 6 Weizmann St., Tel-Aviv, Israel
    • The Institute of Pathology, Sheba Medical Center, Tel-Hashomer, Israel
    • ,
  • Dror Harats

      Affiliations

    • The Institute for Lipid and Atherosclerosis Research, Sheba Medical Center, Tel-Hashomer, Israel
    • ,
  • Arie Roth

      Affiliations

    • Department of Cardiology and the Cardiovascular Research Laboratory, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, 6 Weizmann St., Tel-Aviv, Israel
    • ,
  • Gad Keren

      Affiliations

    • Department of Cardiology and the Cardiovascular Research Laboratory, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, 6 Weizmann St., Tel-Aviv, Israel
    • ,
  • Jacob George

      Affiliations

    • Department of Cardiology and the Cardiovascular Research Laboratory, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, 6 Weizmann St., Tel-Aviv, Israel
    • Corresponding Author InformationCorresponding author. Fax: +972 3 5469832.

Received 13 November 2004 ,Revised 7 February 2005 ,Accepted 2 March 2005.

References 

  1. Libby P. Inflammation in atherosclerosis. Nature. 2002;420:868–874
  2. Binder CJ, Chang MK, Shaw PX, et al. Innate and acquired immunity in atherogenesis. Nat Med. 2002;8:1218–1226
  3. Hansson GK, Libby P, Schonbeck U, et al. Innate and adaptive immunity in the pathogenesis of atherosclerosis. Circ Res. 2002;23(91):281–291
  4. Xu Q, Dietrich H, Steiner HJ, et al. Induction of arteriosclerosis in normocholesterolemic mice rabbits by immunization with heat shock protein 65. Arterioscler Thromb. 1992;12:789–799
  5. Wick G, Perschinka H, Millonig G. Atherosclerosis as an autoimmune disease: an update. Trends Immunol. 2001;22:665–669
  6. George J, Afek A, Gilburd B, et al. Induction of early atherosclerosis in LDL receptor deficient mice immunized with beta 2 glycoprotein I. Circulation. 1998;15:1108–1115
  7. Zhou X, Nicoletti A, Elhage R, et al. Transfer of CD4 (+) T cells aggravates atherosclerosis in immunodeficient apolipoprotein E knockout mice. Circulation. 2000;12:2919–2922
  8. George J, Harats D, Gilburd B, et al. Adoptive transfer of beta(2)-glycoprotein I-reactive lymphocytes enhances early atherosclerosis in LDL receptor-deficient mice. Circulation. 2000;10:1822–1827
  9. George J, Afek A, Gilburd B, et al. Cellular and humoral immune responses to heat shock protein 65 are both involved in promoting fatty-streak formation in LDL-receptor deficient mice. J Am Coll Cardiol. 2001;38:900–905
  10. Greenfield EA, Nguyen KA, Kuchroo VK. CD28/B7 costimulation: a review. Crit Rev Immunol. 1998;18:389
  11. Yoshinaga SK, et al. T-cell co-stimulation through B7RP-1 and ICOS. Nature. 1999;402:827–832
  12. Hutloff A, Dittrich AM, Beier KC, et al. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature. 1999;397:263–266
  13. McAdam AJ, Greenwald RJ, Levin MA, et al. ICOS is critical for CD40-mediated Ab class switching. Nature. 2001;409:102–105
  14. Tafuri A, et al. ICOS is essential for effective T-helper-cell responses. Nature. 2001;105–109
  15. Nurieva RI, Treuting P, Duong J, Flavell RA, Dong C. Inducible costimulator is essential for collagen-induced arthritis. J Clin Invest. 2003;111:701–706
  16. Totsuka T, Kanai T, Iiyama R, et al. Ameliorating effect of anti-inducible costimulator monoclonal antibody in a murine model of chronic colitis. Gastroenterology. 2003;124:410–421
  17. Rottman JB, Smith T, Tonra JR, et al. The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE. Nat Immunol. 2001;2:605–611
  18. Harada H, Salama AD, Sho M, et al. The role of the ICOS-B7h T cell costimulatory pathway in transplantation immunity. J Clin Invest. 2003;112:234–243
  19. Swallow MM, Wallin JJ, Sha WC. B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFa. Immunity. 1999;11:423–432
  20. Plump AS, Smith JD, Hayek T, et al. Severe hypercholesterolemia and atherosclerosis in apolipoprotein-E deficient mice created by homologous recombination in ES cells. Cell. 1992;71:343–353
  21. Dansky HM, Charlton SA, McGee-Harper M, et al. T and B lymphocytes play a minor role in atherosclerotic plaque formation in the apolipoprotein E-deficient mouse. Proc Natl Acad Sci USA. 1997;94:4642–4646
  22. Song L, Leung C, Schindler C. Lymphocytes are important in early atherosclerosis. J Clin Invest. 2001;108:251–259
  23. Schonbeck U, Libby P. CD40 signaling and plaque instability. Circ Res. 2001;89:1092–103
  24. Palinski W, Miller E, Witztum JL. Immunization of low density lipoprotein (LDL) receptor-deficient rabbits with homologous malondialdehyde-modified LDL reduces atherogenesis. Proc Natl Acad Sci USA. 1995;92:821–825
  25. George J, Afek A, Gilburd B, et al. Hyperimmunization of chow-fed apoE deficient mice with homologous oxidized low density lipoprotein suppresses early atherogenesis. Atherosclerosis. 1998;138:147–152
  26. Binder CJ, Horkko S, Dewan A, et al. Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL. Nat Med. 2003;9:736–743
  27. Gupta S, Pablo AM, Jiang X, Wang N, Tall AR, Schindler C. IFN-gamma potentiates atherosclerosis in ApoE knock-out mice. J Clin Invest. 1997;99:2752–2761
  28. Whitman SC, Ravisankar P, Elam H, Daugherty A. Exogenous interferon-gamma enhances atherosclerosis in apolipoprotein E−/− mice. Am J Pathol. 2000;157:1819–1824
  29. Mallat Z, Besnard S, Duriez M, et al. Protective role of interleukin-10 in atherosclerosis. Circ Res. 1999;85:e17–e24
  30. Von Der Thusen JH, Kuiper J, et al. Attenuation of atherogenesis by systemic and local adeno virus-mediated gene transfer of interleukin-10 in LDLr−/− mice. FASEB J. 2001;15:2730–2732

PII: S0021-9150(05)00193-0

doi: 10.1016/j.atherosclerosis.2005.03.040

Atherosclerosis
Volume 183, Issue 1 , Pages 57-63 , November 2005

Article Tools

* Image Usage & Resolution