Atherosclerosis
Volume 183, Issue 2 , Pages 259-267 , December 2005

Intermittent high glucose enhances ICAM-1, VCAM-1 and E-selectin expression in human umbilical vein endothelial cells in culture: The distinct role of protein kinase C and mitochondrial superoxide production

  • Lisa Quagliaro

      Affiliations

    • Morpurgo-Hofman Research Laboratory on Aging, Udine, Italy
  • ,
  • Ludovica Piconi

      Affiliations

    • Morpurgo-Hofman Research Laboratory on Aging, Udine, Italy
  • ,
  • Roberta Assaloni

      Affiliations

    • Department of Pathology and Medicine, Experimental and Clinical, University of Udine, Chair of Internal Medicine, P.le S. Maria Della Misericordia, 33100 Udine, Italy
  • ,
  • Roberto Da Ros

      Affiliations

    • Department of Pathology and Medicine, Experimental and Clinical, University of Udine, Chair of Internal Medicine, P.le S. Maria Della Misericordia, 33100 Udine, Italy
  • ,
  • Amabile Maier

      Affiliations

    • Department of Pathology and Medicine, Experimental and Clinical, University of Udine, Chair of Internal Medicine, P.le S. Maria Della Misericordia, 33100 Udine, Italy
  • ,
  • Gianni Zuodar

      Affiliations

    • Department of Pathology and Medicine, Experimental and Clinical, University of Udine, Chair of Internal Medicine, P.le S. Maria Della Misericordia, 33100 Udine, Italy
  • ,
  • Antonio Ceriello

      Affiliations

    • Department of Pathology and Medicine, Experimental and Clinical, University of Udine, Chair of Internal Medicine, P.le S. Maria Della Misericordia, 33100 Udine, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 0432 559813; fax: +39 0432 42097.

Received 13 October 2004 ,Revised 14 March 2005 ,Accepted 21 March 2005.

References 

  1. Kannel WB, McGee DL. Diabetes and cardiovascular diseases. The Framingham study. JAMA. 1979;241:2035–2038
  2. Lopes-Virella MF, Virella G. Immune mechanism of atherosclerosis in diabetes mellitus. Diabetes. 1992;41(Suppl. 2):86–91
  3. Wood KM, Cadogan MD, Ramshaw AL, Parums DV. The distribution of adhesion molecules in human atherosclerosis. Histopathology. 1993;22:437–444
  4. Kado S, Wakatsuki T, Yamamoto M, Nagata N. Expression of intracellular adhesion molecule-1 induced by high glucose concentrations in human aortic endothelial cells. Life Sci. 2001;68:727–737
  5. Morigi M, Angioletti S, Imberti B, et al. Leukocyte-endothelial interaction is augmented by high glucose concentrations and hyperglycemia in a NF-κB-dependent fashion. J Clin Invest. 1998;101:1905–1915
  6. Kim I, Moon SO, Kim SH, et al. Vascular endothelial growth factor expression of intracellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-κB activation in endothelial cells. J Biol Chem. 2001;276:7614–7620
  7. Koya D, King GL. Protein kinase C activation and the development of diabetic complications. Diabetes. 1998;47:859–866
  8. Risso A, Mercuri F, Quagliaro L, Damante G, Ceriello A. Intermittent high glucose enhances apoptosis in human umbilical vein endothelial cells in culture. Am J Physiol. 2001;281:E924–E930
  9. Quagliaro L, Piconi L, Assaloni R, et al. Intermittent high glucose enhances apoptosis related to oxidative stress in human umbilical vein endothelial cells: the role of protein kinase C and NAD(P)H-oxidase activation. Diabetes. 2003;52:2795–2804
  10. Nishikawa TED, Du XL, Yamagishi S, et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature. 2000;404:787–790
  11. Inoguchi T, Battan R, Handler E, et al. Preferential elevation of protein kinase C isoform βII and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. Procl Natl Acad Sci USA. 1992;89:11059–11063
  12. Richter C, Park JW, Ames BN. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci USA. 1988;85:6465–6467
  13. Kasai H, Crain PF, Kuchino Y, et al. Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair. Carcinogenesis. 1986;7:1849–1851
  14. Jaffe EA, Nachman RL, Becker CG, Minich CR. Culture of human endothelial cells derived from umbilical veins. J Clin Invest. 1973;52:2745–2752
  15. Sowers JR, Epstein M, Frohlich ED. Diabetes, hypertension, and cardiovascular disease: an update. Hypertension. 2001;37:1053–1059
  16. The Diabetes Control and Complications Trials (DCCT) Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993;329:977–986.
  17. UK Propsective Diabetes Study Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998;352:837–853.
  18. Laakso M. Hyperglycemia and cardiovascular disease in type 2 diabetes. Diabetes. 1999;48:937–942
  19. Bonora E, Muggeo M. Postprandial blood glucose as a risk factor for cardiovascular disease in type II diabetes: the epidemiological evidence. Diabetologia. 2001;44:2107–2114
  20. Ceriello A. The emerging role of post-prandial hyperglycaemic spikes in the pathogenesis of diabetic complications. Diabet Med. 1998;15:188–193
  21. Ceriello A, Falletti E, Motz E, et al. Hyperglycemia-induced ICAM-1 increase in diabetes mellitus: the possibile role of oxidative stress. Horm Metab Res. 1998;30:146–149
  22. Marfella R, Esposito K, Giunta R, et al. Circulating adhesion molecules in humans: role of hyperglycemia and hyperinsulinemia. Circulation. 2000;101:2247–2251
  23. Nappo F, Esposito K, Ciuffi M, et al. Posprandial endothelial activation in healthy subjects and in type 2 diabetic patients: role of fat and carbohydrate meals. J Am Coll Cardiol. 2002;39:1145–1150
  24. Ceriello A, Quagliaro L, Piconi L, et al. Effect of postprandial hypertriglyceridemia and hyperglycemia on circulating adhesion molecules and oxidative stress generation and the possible role of simvastatin treatment. Diabetes. 2004;53:701–710
  25. Baumgartner-Parzer SM, Wagner L, Pattermann M, Gessi A, Waldhäusl W. Modulation by high glucose of adhesion molecules expression in cultured endothelial cells. Diabetologia. 1995;38:1367–1370
  26. Rahman A, Bando M, Kefer J, Anwar KB, Malik AB. Protein kinase C-activated oxidant generation in endothelial cells signals intracellular adhesion molecule-1 gene transcription. Mol Pharm. 1999;55:575–583
  27. Tamaru M, Narumi S. E-selectin expression is induced synergistically with the coexistance of activated classic protein kinase C and signals elicited by interleukin-1β but not tumor necrosis factor-α. J Biol Chem. 1999;274:3753–3763
  28. Booth G, Stalker TJ, Lefer AM, Scalia R. Mechanisms of amelioration of glucose-induced endothelial dysfunction following inhibition of protein kinase C in vivo. Diabetes. 2002;51:1556–1564
  29. Kouroedov A, Eto M, Joch H, Volpe M, Luscher TF, Cosentino F. Selective inhibition of protein Kinase C(beta)2 prevents acute effects of high glucose on vascular cell adhesion molecule-1 expression in human endothelial cells. Circulation 2004 June 21 [Epub ahead of print].
  30. Inoguchi T, Li P, Umeda F, et al. High glucose level and free fatty acid stimulate reactive oxygen species production through Protein Kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes. 2000;49:1939–1945

PII: S0021-9150(05)00223-6

doi: 10.1016/j.atherosclerosis.2005.03.015

Atherosclerosis
Volume 183, Issue 2 , Pages 259-267 , December 2005