Atherosclerosis
Volume 185, Issue 2 , Pages 264-270 , April 2006

Estradiol fatty acid esterification is increased in high density lipoprotein subclass 3 isolated from hypertriglyceridemic subjects

  • Anna Höckerstedt

      Affiliations

    • Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, FIN-00290 Helsinki, Finland
    • Corresponding Author InformationCorresponding author. Tel.: +358 9 47171881; fax: +358 9 47171882.
    • ,
  • Matti Jauhiainen

      Affiliations

    • Department of Molecular Medicine, National Public Health Institute, Biomedicum, FIN-00290 Helsinki, Finland
    • ,
  • Matti J. Tikkanen

      Affiliations

    • Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, FIN-00290 Helsinki, Finland

Received 2 December 2004 ,Revised 21 June 2005 ,Accepted 22 June 2005.

References 

  1. Lamarche B, Despres JP, Moorjani S, Cantin B, Dagenais GR, Lupien PJ. Triglycerides and HDL-cholesterol as risk factors for ischemic heart disease. Results from the Quebec cardiovascular study. Atherosclerosis. 1996;119:235–245
  2. Chang LB, Hopkins GJ, Barter PJ. Particle size distribution of high density lipoproteins as a function of plasma triglyceride concentration in human subjects. Atherosclerosis. 1985;56:61–70
  3. Lamarche B, Rashid S, Lewis GF. HDL metabolism in hypertriglyceridemic states: an overview. Clin Chim Acta. 1999;286:145–161
  4. Barrans A, Collet X, Barbaras R, et al. Hepatic lipase induces the formation of pre-beta 1 high density lipoprotein (HDL) from triacylglycerol-rich HDL2. A study comparing liver perfusion to in vitro incubation with lipases. J Biol Chem. 1994;269:11572–11577
  5. Clay MA, Newnham HH, Forte TM, Barter PI. Cholesteryl ester transfer protein and hepatic lipase activity promote shedding of apoA–I from HDL and subsequent formation of discoidal HDL. Biochim Biophys Acta. 1992;1124:52–58
  6. Lewis GF, Steiner G. Hypertriglyceridemia and its metabolic consequences as a risk factor for atherosclerotic cardiovascular disease in non-insulin-dependent diabetes mellitus. Diabetes Metab Rev. 1996;12:37–56
  7. Rye KA, Jauhiainen M, Barter PJ, Ehnholm C. Triglyceride-enrichment of high density lipoproteins enhances their remodelling by phospholipid transfer protein. J Lipid Res. 1998;39:613–622
  8. Fielding CJ, Fielding PE. Purification and substrate specificity of lecithin-cholesterol acyl transferase from human plasma. FEBS Lett. 1971;15:355–358
  9. Barter PJ, Rye KA. Molecular mechanisms of reverse cholesterol transport. Curr Opin Lipidol. 1996;7:82–87
  10. Saku K, Ahmad M, Glas-Greenwalt P, Kashyap ML. Activation of fibrinolysis by apolipoproteins of high density lipoproteins in man. Thromb Res. 1985;39:1–8
  11. Cockerill GW, Rye KA, Gamble JR, Vadas MA, Barter PJ. High-density lipoproteins inhibit cytokine-induced expression of endothelial cell adhesion molecules. Arterioscler Thromb Vasc Biol. 1995;15:1987–1994
  12. Mackness MI, Durrington PN. HDL, its enzymes and its potential to influence lipid peroxidation. Atherosclerosis. 1995;115:243–253
  13. Banka CL. High density lipoprotein and lipoprotein oxidation. Curr Opin Lipidol. 1996;7:139–142
  14. Francis GA. High density lipoprotein oxidation: in vitro susceptibility and potential in vivo consequences. Biochim Biophys Acta. 2000;1483:217–235
  15. Mendelsohn ME. Protective effects of estrogen on the cardiovascular system. Am J Cardiol. 2002;89:12E–17EDiscussion 17E-18E
  16. Höckerstedt A, Tikkanen MJ, Jauhiainen M. LCAT facilitates transacylation of 17 beta-estradiol in the presence of HDL3 subfraction. J Lipid Res. 2002;43:392–397
  17. Kanji SS, Kuohung W, Labaree DC, Hochberg RB. Regiospecific esterification of estrogens by lecithin:cholesterol acyltransferase. J Clin Endocrinol Metab. 1999;84:2481–2488
  18. Shwaery GT, Vita JA, Keaney JF. Antioxidant protection of LDL by physiological concentrations of 17 beta-estradiol. Requirement for estradiol modification. Circulation. 1997;95:1378–1385
  19. Tikkanen MJ, Vihma V, Höckerstedt A, Jauhiainen M, Helisten H, Kaamanen M. Lipophilic oestrogen derivatives contained in lipoprotein particles. Acta Physiol Scand. 2002;176:117–121
  20. Hochberg RB. Biological esterification of steroids. Endocr Rev. 1998;19:331–348
  21. Tang M, Abplanalp W, Subbiah MT. Association of estrogens with human plasma lipoproteins: studies using estradiol-17beta and its hydrophobic derivative. J Lab Clin Med. 1997;129:447–452
  22. Havel RJ, Eder HA, Bragdon JH. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest. 1955;34:1345–1353
  23. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265–275
  24. Jauhiainen M, Dolphin PJ. Human plasma lecithin-cholesterol acyltransferase. An elucidation of the catalytic mechanism. J Biol Chem. 1986;261:7032–7043
  25. Zhou GY, Jauhiainen M, Stevenson K, Dolphin PJ. Human plasma lecithin:cholesterol acyltransferase. Preparation and use of immobilized p-aminophenylarsenoxide as a catalytic site-directed covalent ligand in enzyme purification. J Chromatogr. 1991;568:69–83
  26. Vihma V, Tiitinen A, Ylikorkala O, Tikkanen MJ. Quantitative determination of estradiol fatty acid esters in lipoprotein fractions in human blood. J Clin Endocrinol Metab. 2003;88:2552–2555
  27. Esterbauer H, Striegl G, Puhl H, Rotheneder M. Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Radic Res Commun. 1989;6:67–75
  28. Helisten H, Höckerstedt A, Wähälä K, et al. Accumulation of high-density lipoprotein-derived estradiol-17beta fatty acid esters in low-density lipoprotein particles. J Clin Endocrinol Metab. 2001;86:1294–1300
  29. Vohl MC, Neville TA, Kumarathasan R, Braschi S, Sparks DL. A novel lecithin-cholesterol acyltransferase antioxidant activity prevents the formation of oxidized lipids during lipoprotein oxidation. Biochemistry. 1999;38:5976–5981
  30. Goyal J, Wang K, Liu M, Subbaiah PV. Novel function of lecithin-cholesterol acyltransferase. Hydrolysis of oxidized polar phospholipids generated during lipoprotein oxidation. J Biol Chem. 1997;272:16231–16239
  31. Dolphin PJ. In:  Rosseneu M editors. Structure and function of apolipoproteins. CRC Press; 1992;p. 295–362
  32. Pinon JC, Bridoux AM, Laudat MH. Initial rate of cholesterol esterification association with high density lipoproteins in human plasma. J Lipid Res. 1980;21:406–414
  33. Settasatian N, Duong M, Curtiss LK, et al. The mechanism of the remodeling of high density lipoproteins by phospholipid transfer protein. J Biol Chem. 2001;276:26898–26905
  34. Frank PG, Bergeron J, Emmanuel F, et al. Deletion of central alpha-helices in human apolipoprotein A–I: effect on phospholipid association. Biochemistry. 1997;36:1798–1806
  35. Roosbeek S, Vanloo B, Duverger N, et al. Three arginine residues in apolipoprotein A–I are critical for activation of lecithin:cholesterol acyltransferase. J Lipid Res. 2001;42:31–40

PII: S0021-9150(05)00440-5

doi: 10.1016/j.atherosclerosis.2005.06.032

Atherosclerosis
Volume 185, Issue 2 , Pages 264-270 , April 2006

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