Atherosclerosis
Volume 185, Issue 2 , Pages 278-281 , April 2006

The combination of high dietary methionine plus cholesterol induces myocardial fibrosis in rabbits

  • Anthony Zulli

      Affiliations

    • Vascular Laboratory, Department of Cardiology, University of Melbourne, Austin Health, Heidelberg, Australia
    • Department of Medicine, University of Melbourne, Austin Health, Australia
    • Corresponding Author InformationCorresponding author. Tel.: 61 3 9496 2955; fax: 61 3 9497 4554.
    • ,
  • David L. Hare

      Affiliations

    • Vascular Laboratory, Department of Cardiology, University of Melbourne, Austin Health, Heidelberg, Australia
    • Department of Medicine, University of Melbourne, Austin Health, Australia
    • ,
  • Brian F. Buxton

      Affiliations

    • Department of Cardiac Surgery, University of Melbourne, Austin Health, Australia
    • ,
  • M. Jane Black

      Affiliations

    • Department of Anatomy and Cell Biology, Monash University, Clayton, Australia

Received 18 April 2005 ,Revised 7 June 2005 ,Accepted 21 June 2005.

References 

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  2. Weber KT, Brilla CG, Janicki JS. Myocardial fibrosis: functional significance and regulatory factors. Cardiovasc Res. 1993;27:341–348
  3. Burlew BS, Weber KT. Connective tissue and the heart. Functional significance and regulatory mechanisms. Cardiol Clin. 2000;18:435–442
  4. Capasso JM, Palackal T, Olivetti G, Anversa P. Severe myocardial dysfunction induced by ventricular remodeling in aging rat hearts. Am J Physiol. 1990;259:H1086–H1096
  5. Spach MS, Boineau JP. Microfibrosis produces electrical load variations due to loss of side-to-side cell connections: a major mechanism of structural heart disease arrhythmias. Pacing Clin Electrophysiol. 1997;20:397–413
  6. Zulli A, Widdop RE, Hare DL, Buxton BF, Black MJ. High methionine and cholesterol diet abolishes endothelial relaxation. Arterioscler Thromb Vasc Biol. 2003;23:1358–1363
  7. Zulli A, Hare DL, Buxton BF, Black MJ. High dietary methionine plus cholesterol exacerbates atherosclerosis formation in the left main coronary artery of rabbits. Atherosclerosis. 2004;176:83–89
  8. Yu HC, Burrell LM, Black MJ, et al. Salt induces myocardial and renal fibrosis in normotensive and hypertensive rats. Circulation. 1998;98:2621–2628
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  10. Kato H, Okada R, Enoki M, et al. The antiatherogenic effect of nifedipine on intramural small coronary arterial lesions in cholesterol-fed rabbits. Angiology. 1998;49:49–54
  11. Takemoto M, Egashira K, Usui M, et al. Important role of tissue angiotensin-converting enzyme activity in the pathogenesis of coronary vascular and myocardial structural changes induced by long-term blockade of nitric oxide synthesis in rats. J Clin Invest. 1997;99:278–287
  12. Takemoto M, Egashira K, Tomita H, et al. Chronic angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade: effects on cardiovascular remodeling in rats induced by the long-term blockade of nitric oxide synthesis. Hypertension. 1997;30:1621–1627
  13. Kobayashi N, Hara K, Watanabe S, Higashi T, Matsuoka H. Effect of imidapril on myocardial remodeling in L-NAME-induced hypertensive rats is associated with gene expression of NOS and ACE mRNA. Am J Hypertens. 2000;13:199–207

PII: S0021-9150(05)00442-9

doi: 10.1016/j.atherosclerosis.2005.06.036

Atherosclerosis
Volume 185, Issue 2 , Pages 278-281 , April 2006

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