Atherosclerosis
Volume 185, Issue 2 , Pages 282-289 , April 2006

Oxidized LDL induces a coordinated up-regulation of the glutathione and thioredoxin systems in human macrophages

  • Daniel Hägg

      Affiliations

    • Research Centre for Endocrinology and Metabolism, Division of Body Composition and Metabolism, Department of Internal Medicine, Vita stråket 15, Sahlgrenska University Hospital, S-413 45 Göteborg, Sweden
    • Corresponding Author InformationCorresponding author. Tel.: +46 31 342 40 46; fax: +46 31 41 85 27.
    • ,
  • Mikael C.O. Englund

      Affiliations

    • Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden
    • ,
  • Margareta Jernås

      Affiliations

    • Research Centre for Endocrinology and Metabolism, Division of Body Composition and Metabolism, Department of Internal Medicine, Vita stråket 15, Sahlgrenska University Hospital, S-413 45 Göteborg, Sweden
    • ,
  • Caroline Schmidt

      Affiliations

    • Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden
    • ,
  • Olov Wiklund

      Affiliations

    • Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden
    • ,
  • Lillemor Mattsson Hultén

      Affiliations

    • Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden
    • ,
  • Bertil G. Ohlsson

      Affiliations

    • Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden
    • ,
  • Lena M.S. Carlsson

      Affiliations

    • Research Centre for Endocrinology and Metabolism, Division of Body Composition and Metabolism, Department of Internal Medicine, Vita stråket 15, Sahlgrenska University Hospital, S-413 45 Göteborg, Sweden
    • ,
  • Björn Carlsson

      Affiliations

    • Research Centre for Endocrinology and Metabolism, Division of Body Composition and Metabolism, Department of Internal Medicine, Vita stråket 15, Sahlgrenska University Hospital, S-413 45 Göteborg, Sweden
    • ,
  • Per-Arne Svensson

      Affiliations

    • Research Centre for Endocrinology and Metabolism, Division of Body Composition and Metabolism, Department of Internal Medicine, Vita stråket 15, Sahlgrenska University Hospital, S-413 45 Göteborg, Sweden
    • Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden

Received 12 April 2005 ,Revised 14 June 2005 ,Accepted 21 June 2005.

References 

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  4. Nordberg J, Arner ES. Reactive oxygen species, antioxidants, and the mammalian thioredoxin system. Free Radic Biol Med. 2001;31:1287–1312
  5. Morrison JA, Jacobsen DW, Sprecher DL, et al. Serum glutathione in adolescent males predicts parental coronary heart disease. Circulation. 1999;100:2244–2247
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  17. Okuda M, Inoue N, Azumi H, et al. Expression of glutaredoxin in human coronary arteries: its potential role in antioxidant protection against atherosclerosis. Arterioscler Thromb Vasc Biol. 2001;21:1483–1487
  18. Berliner JA, Territo MC, Sevanian A, et al. Minimally modified low density lipoprotein stimulates monocyte endothelial interactions. J Clin Invest. 1990;85:1260–1266
  19. Furman C, Rundlof AK, Larigauderie G, et al. Thioredoxin reductase 1 is upregulated in atherosclerotic plaques: specific induction of the promoter in human macrophages by oxidized low-density lipoproteins. Free Radic Biol Med. 2004;37:71–85
  20. Yang H, Roberts LJ, Shi MJ, et al. Retardation of atherosclerosis by overexpression of catalase or both Cu/Zn-superoxide dismutase and catalase in mice lacking apolipoprotein E. Circ Res. 2004;95:1075–1081
  21. Matsui M, Oshima M, Oshima H, et al. Early embryonic lethality caused by targeted disruption of the mouse thioredoxin gene. Dev Biol. 1996;178:179–185
  22. Dalton TP, Dieter MZ, Yang Y, Shertzer HG, Nebert DW. Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous. Biochem Biophys Res Commun. 2000;279:324–329

PII: S0021-9150(05)00443-0

doi: 10.1016/j.atherosclerosis.2005.06.034

Atherosclerosis
Volume 185, Issue 2 , Pages 282-289 , April 2006

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