Atherosclerosis
Volume 186, Issue 1 , Pages 54-64 , May 2006

Plasma insulin levels predict atherosclerotic lesion burden in obese hyperlipidemic mice

Received 3 February 2005 ,Revised 21 June 2005 ,Accepted 6 July 2005.

References 

  1. Reaven GM. Role of insulin resistance in human disease. Diabetes. 1988;37:1595–1607
  2. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1. Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diab Med. 1998;15:539–553
  3. Isomaa B, Almgren P, Tuomi T, et al. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diab Care. 2001;24:683–689
  4. Nishina PM, Naggert JK, Verstuyft J, Paigen B. Atherosclerosis in genetically obese mice: the mutants obese, diabetes, fat, tubby, and lethal yellow. Metabolism. 1994;43:554–558
  5. Nishina PM, Lowe S, Wang J, Paigen B. Characterization of plasma lipids in genetically obese mice: the mutants obese, diabetes, fat, tubby, and lethal yellow. Metabolism. 1994;43:549–553
  6. Silver DL, Jiang X-C, Tall AR. Increased high density lipoprotein (HDL), defective hepatic catabolism of apoA-I and apoA-II, and decreased apoA-I mRNA in ob/ob mice. J Biol Chem. 1999;274:4140–4146
  7. Renard CB, Kramer F, Johansson F, et al. Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesions. J Clin Invest. 2004;114:659–668
  8. Hasty A, Shimano H, Osuga J, et al. Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice packing both leptin and the low density lipoprotein receptor. J Biol Chem. 2001;276:37402–37408
  9. Plump AS, Smith JD, Hayek T, et al. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell. 1992;71:343–353
  10. Zhang SH, Reddick RL, Piedrahita JA, Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science. 1992;258:468–471
  11. Lyngdorf L, Gregersen S, Daugherty A, Falk E. Paradoxical reduction of atherosclerosis in apoE-deficient mice with obesity-related type 2 diabetes. Cardiovasc Res. 2003;59:854–862
  12. Schreyer S, Vick C, Lystig T, Mystkowski P, LeBoeuf R. LDL receptor but not apolipoprotein E deficiency increases diet-induced obesity and diabetes in mice. Am J Physiol Endocrinol Metab. 2002;282:207–214
  13. Schreyer S, Lystig T, Vick C, LeBoeuf R. Mice deficient in apolipoprotein E but not LDL receptors are resistant to accelerated atherogenesis associated with obesity. Atherosclerosis. 2003;171:49–55
  14. Brissova M, Nicholson WE, Shiota M, Powers AC. Assessment of insulin secretion in the mouse. Meth Mol Med. 2003;83:23–45
  15. Fazio S, Hasty AH, Carter KJ, et al. Leukocyte low density lipoprotein receptor (LDL-R) does not contribute to LDL clearance in vivo: bone marrow transplantation studies in the mouse. J Lipid Res. 1997;38:391–400
  16. Hasty AH, Linton MF, Swift LL, Fazio S. Determination of the lower threshold of apolipoprotein E resulting in remnant lipoprotein clearance. J Lipid Res. 1999;40:1529–1538
  17. Linton MF, Hasty AH, Babaev VR, Fazio S. Hepatic apoE expression is required for remnant lipoprotein clearance in the absence of the low density lipoprotein receptor. J Clin Invest. 1998;101:1726–1736
  18. Folch J, Lees M, Stanley GHS. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 1957;226:497–509
  19. Morrison WR, Smith LM. Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride–methanol. J Lipid Res. 1964;53:600–608
  20. Rudel LL, Kelley K, Sawyer JK, Shah R, Wilson MD. Dietary monounsaturated fatty acids promote aortic atherosclerosis in LDL receptor-null, human apoB100-overexpressing transgenic mice. Arterioscl Thromb Vasc Biol. 1998;18:1818–1827
  21. Paigen B, Morrow A, Holmes PA, Mitchell D, Williams RA. Quantitative assessment of atherosclerotic lesions in mice. Atherosclerosis. 1987;68:231–240
  22. Tangirala RK, Rubin EM, Palinski W. Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice. J Lipid Res. 1995;36:2320–2328
  23. Babaev VR, Patel MB, Semenkovich CF, Fazio S, Linton MF. Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in low density lipoprotein receptor-deficient mice. J Biol Chem. 2000;275:26293–26299
  24. Mertens A, Verhamme P, Bielicki JK, et al. Increased low-density lipoprotein oxidation and impaired high-density lipoprotein antioxidant defense are associated with increased macrophage homing and atherosclerosis in dyslipidemic obese mice: LCAT gene transfer decreases atherosclerosis. Circulation. 2003;107:1640–1646
  25. Chiba T, Nakazawa T, Yui K, Kaneko E, Shimokado K. VLDL induces adipocyte differentiation in ApoE-dependent manner. Arterioscler Thromb Vasc Biol. 2003;23:1423–1429
  26. Hasty AH, Linton MF, Brandt SJ, et al. Retroviral gene therapy in ApoE-deficient mice: ApoE expression in the artery wall reduces early foam cell lesion formation. Circulation. 1999;99:2571–2576
  27. Yoshida H, Hasty A, Major AS, et al. Isoform-specific effects of apolipoprotein E on atherogenesis: gene transduction studies in apoE-null mice. Circulation. 2001;104:2820–2825
  28. American Diabetes Association, The National Heart, Lung, and Blood Institute, The Juvenile Diabetes Foundation International, The National Institute of Diabetes and Digestive and Kidney Diseases, The American Heart Association. Diabetes mellitus: a major risk factor for cardiovascular disease. Circulation. 1999;100:1132–1133(a joint editorial statement)
  29. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 2001;285:2486–2497
  30. Oram JF, Bornfeldt KE. Direct effects of long-chain non-esterified fatty acids on vascular cells and their relevance to macrovascular complications of diabetes. Front Biosci. 2004;9:1240–1253
  31. Semenkovich CF. Fatty acid metabolism and vascular disease. Trends Cardiovasc Med. 2004;14:72–76
  32. Saraswathi V, Wu G, Toborek M, Hennig B. Linoleic acid-induced endothelial activation: role of calcium and peroxynitrite signaling. J Lipid Res. 2004;45:794–804
  33. Schreyer SA, Wilson DL, LeBoeuf RC. C57BL/6 mice fed high fat diets as models for diabetes-accelerated atherosclerosis. Atherosclerosis. 1998;136:17–24
  34. Verreth W, De Keyzer D, Pelat M, et al. Weight-loss-associated induction of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma correlate with reduced atherosclerosis and improved cardiovascular function in obese insulin-resistant mice. Circulation. 2004;110:3259–3269

PII: S0021-9150(05)00458-2

doi: 10.1016/j.atherosclerosis.2005.07.007

Atherosclerosis
Volume 186, Issue 1 , Pages 54-64 , May 2006