Atherosclerosis
Volume 186, Issue 1 , Pages 74-79 , May 2006

P-selectin Thr715Pro polymorphism predicts P-selectin levels but not risk of incident coronary heart disease or ischemic stroke in a cohort of 14595 participants: The Atherosclerosis Risk In Communities Study

  • Kelly A. Volcik

      Affiliations

    • Human Genetics Center, University of Texas Houston Health Science Center, 1200 Herman Pressler Dr., Houston, TX 77030, USA
    • ,
  • Christie M. Ballantyne

      Affiliations

    • Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    • ,
  • Josef Coresh

      Affiliations

    • Department of Epidemiology, John Hopkins University, Baltimore, MD, USA
    • ,
  • Aaron R. Folsom

      Affiliations

    • Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA
    • ,
  • Kenneth K. Wu

      Affiliations

    • Department of Hematology, University of Texas Health Science Center, Houston, TX, USA
    • ,
  • Eric Boerwinkle

      Affiliations

    • Human Genetics Center, University of Texas Houston Health Science Center, 1200 Herman Pressler Dr., Houston, TX 77030, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 713 500 9800; fax: +1 713 500 0900.

Received 5 April 2005 ,Revised 30 June 2005 ,Accepted 8 July 2005.

References 

  1. Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med. 1999;340:115–126
  2. Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005;352:1685–1695
  3. Albelda SM, Smith CW, Ward PA. Adhesion molecules and inflammatory injury. FASEB J. 1994;8:504–512
  4. Price DT, Loscalzo J. Cellular adhesion molecules and atherogenesis. Am J Med. 1999;107:85–97
  5. Elangbam CS, Qualls CW, Dahlgren RR. Cell adhesion molecules—update. Vet Pathol. 1997;34:61–73
  6. Johnson RC, Chapman SM, Dong ZM, et al. Absence of P-selectin delays fatty streak formation in mice. J Clin Invest. 1997;99(5):1037–1043
  7. Nageh MF, Sandberg ET, Marotti KR, et al. Deficiency of inflammatory cell adhesion molecules protects against atherosclerosis in mice. Arterioscler Thromb Vasc Biol. 1997;17:1517–1520
  8. Dong ZM, Brown AA, Wagner DD. Prominent role of P-selectin in the development of advanced atherosclerosis in ApoE-deficient mice. Circulation. 2000;101:2290–2295
  9. Collins RG, Velji R, Guevara NV, Hicks MJ, Chan L, Beaudet AL. P-selectin or intercellular adhesion molecule (ICAM-1) deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient mice. J Exp Med. 2000;191:189–194
  10. Manka D, Collins RG, Ley K, Beaudet AL, Sarembock IJ. Absence of P-selectin, but not intercellular adhesion molecule-1, attenuates neointimal growth after arterial injury in apolipoprotein E-deficient mice. Circulation. 2001;103:1000–1005
  11. Molenaar TJM, Twisk J, de Haas SAM, et al. P-selectin as a candidate target in atherosclerosis. Biochem Pharm. 2003;66:859–866
  12. Verhaar MC, Beutler JJ, Gaillard CA, Koomans HA, Fijnheer R, Rabelink TJ. Progressive vascular damage in hypertension is associated with increased levels of circulating P-selectin. J Hypert. 1998;16:45–50
  13. Koyama H, Maeno T, Fukumoto S, et al. Platelet P-selectin expression is associated with atherosclerotic wall thickness in carotid artery in humans. Circulation. 2003;108:524–529
  14. Herrmann SM, Ricard S, Nicaud V, et al. The P-selectin gene is highly polymorphic: reduced frequency of the Pro715 allele carriers in patients with myocardial infarction. Hum Mol Genet. 1998;7:1277–1284
  15. Kee F, Morrison C, Evans AE, et al. Polymorphisms of the P-selectin gene and risk of myocardial infarction in men and women in the ECTIM extension study. Heart. 2000;84:548–552
  16. Barbaux SC, Blankenberg S, Rupprecht HJ, et al. Association between P-selectin gene polymorphisms and soluble P-selectin levels and their relation to coronary artery disease. Arterioscler Thromb Vasc Biol. 2001;21:1668–1673
  17. Tregouet DA, Barbaux S, Escolano S, et al. Specific haplotypes of the P-selectin gene are associated with myocardial infarction. Hum Mol Genet. 2002;11(17):2015–2023
  18. Carter AM, Anagnostopoulou K, Mansfield MW, Grant PJ. Soluble P-selectin levels, P-selectin polymorphisms and cardiovascular disease. J Thromb Haemost. 2003;1:1718–1723
  19. Investigators ARIC. The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. Am J Epidemiol. 1989;129:687–702
  20. White A, Folsom A, Chambless L, et al. Community surveillance of coronary heart disease in the Atherosclerosis Risk in Communities (ARIC) Study: methods and initial 2 years’ experience. J Clin Epidemiol. 1996;49:223–233
  21. Rosamond W, Folsom A, Chambless L, et al. Stroke incidence and survival among middle-aged adults: 9-year follow-up of the Atherosclerosis Risk in Communities (ARIC) cohort. Stroke. 1999;30:736–743
  22. Siedel J, Hagele EO, Ziegenhorn J, Wahlefeld AW. Reagent for the enzymatic determination of serum total cholesterol with improved lipolytic efficiency. Clin Chem. 1983;29:1075–1085
  23. Friedwald WT, Levy RI, Frederickson DS. Estimation of the concentration of low-density lipoprotein in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499–502
  24. Warnick GR, Benderson JM, Albers JJ. Quantitation of high-density lipoprotein subclasses after separation by dextran sulfate and Mg2+ precipitation. Clin Chem. 1982;28:1574;(Abstract)
  25. Clauss A. Gerinnungsphysiologische schnellmethode zur bestimmung des fibrinogens. Acta Haematol. 1957;17:237–246
  26. Papp AC, Hatzakis H, Bracey A, Wu KK. ARIC Hemostasis Study. I. Development of blood collection and processing system suitable for multicenter hemostatic studies. Thromb Haemost. 1989;61:15–19
  27. Shah B, Barnwell B, Bieler G. SUDAAN user's manual, Release 7.5. Research Triangle Park, NC: Research Triangle Institute; 1997;
  28. Miller MA, Kerry SM, Dong Y, Strazzullo P, Cappuccio FP. Association between the Thr715Pro P-selectin gene polymorphism and soluble P-selectin levels in a multiethnic population in South London. Thromb Haemost. 2004;92:1060–1065

PII: S0021-9150(05)00466-1

doi: 10.1016/j.atherosclerosis.2005.07.010

Atherosclerosis
Volume 186, Issue 1 , Pages 74-79 , May 2006

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