Atherosclerosis
Volume 186, Issue 1 , Pages 80-85 , May 2006

β-Lipoprotein- and LDL-associated serum γ-glutamyltransferase in patients with coronary atherosclerosis

  • Aldo Paolicchi

      Affiliations

    • Department of Experimental Pathology, Dip. di Patologia Sperimentale and B.M.I.E., University of Pisa Medical School, Scuola Medica, Via Roma 55, 56126 Pisa, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 050 2218533; fax: +39 050 2218557.
    • ,
  • Michele Emdin

      Affiliations

    • Institute of Clinical Physiology, CNR-National Research Council, Pisa, Italy
    • ,
  • Claudio Passino

      Affiliations

    • Institute of Clinical Physiology, CNR-National Research Council, Pisa, Italy
    • ,
  • Evelina Lorenzini

      Affiliations

    • Department of Experimental Pathology, Dip. di Patologia Sperimentale and B.M.I.E., University of Pisa Medical School, Scuola Medica, Via Roma 55, 56126 Pisa, Italy
    • ,
  • Francesca Titta

      Affiliations

    • Department of Experimental Pathology, Dip. di Patologia Sperimentale and B.M.I.E., University of Pisa Medical School, Scuola Medica, Via Roma 55, 56126 Pisa, Italy
    • ,
  • Santino Marchi

      Affiliations

    • Department of Internal Medicine, University of Pisa, Pisa, Italy
    • ,
  • Gino Malvaldi

      Affiliations

    • Department of Experimental Pathology, Dip. di Patologia Sperimentale and B.M.I.E., University of Pisa Medical School, Scuola Medica, Via Roma 55, 56126 Pisa, Italy
    • ,
  • Alfonso Pompella

      Affiliations

    • Department of Experimental Pathology, Dip. di Patologia Sperimentale and B.M.I.E., University of Pisa Medical School, Scuola Medica, Via Roma 55, 56126 Pisa, Italy

Received 21 October 2004 ,Revised 13 July 2005 ,Accepted 14 July 2005.

References 

  1. Meister A. Metabolism and transport of glutathione and other γ-glutamyl compounds. In:  Larsson A,  Orrenius S,  Holmgren A,  Mannervik B editor. Functions of glutathione: biochemical, toxicological and clinical aspects. New York: Raven Press; 1983;p. 1–22
  2. Huseby NE. Multiple forms of gamma-glutamyltransferase in normal human liver, bile and serum. Biochim Biophys Acta. 1978;522:354–362
  3. Huseby NE. Multiple forms of serum gamma-glutamyltransferase. Association of the enzyme with lipoproteins. Clin Chim Acta. 1982;124:103–112
  4. Rollason JG, Pincherle G, Robinson D. Serum gamma-glutamyltranspeptidase in relation to alcohol consumption. Clin Chim Acta. 1972;39:75–80
  5. Brenner H, Rothenbacher D, Arndt V, Schuberth S, Fraisse E, Fliedner TM. Distribution, determinants, and prognostic value of gamma-glutamyltranspeptidase for all-cause mortality in a cohort of construction workers from south Germany. Prev Med. 1997;26:305–310
  6. Betro MG, Oon RC, Edwards JB. Gamma-glutamyl transpeptidase and other liver function tests in myocardial infarction and heart failure. Am J Clin Pathol. 1973;60:679–683
  7. Wannamethee G, Ebrahim S, Shaper AG. Gamma-glutamyltransferase: determinants and association with mortality from ischemic heart disease and all causes. Am J Epidemiol. 1995;142:699–708
  8. Peterson B, Trell E, Kristensson H, Fex G, Yettra M, Hood B. Comparison of gammaglutamyltransferase and other health screening tests in average middle-aged males, heavy drinkers and alcohol non-users. Scand J Clin Lab Invest. 1983;43:141–149
  9. Nilssen O, Førde OH, Brenn T. The Tromsø study — distribution and population determinants of gamma-glutamyltransferase. Am J Epidemiol. 1990;132:318–326
  10. Daeppen JB, Smith TL, Schuckit MA. Influence of age and body mass index on γ-glutamyltransferase activity: a 15-year follow-up evaluation in a community sample. Alcohol Clin Exp Res. 1998;22:941–944
  11. Emdin M, Passino C, Michelassi C, et al. Prognostic value of serum gamma-glutamyl transferase activity after myocardial infarction. Eur Heart J. 2001;22:1802–1807
  12. Paolicchi A, Minotti G, Tonarelli P, et al. Gamma-glutamyl transpeptidase-dependent iron reduction and low density lipoprotein oxidation — a potential mechanism in atherosclerosis. J Invest Med. 1999;47:151–160
  13. Berliner JA, Heinecke JW. The role of oxidized lipoproteins in atherogenesis. Free Rad Biol Med. 1996;20:707–727
  14. Watanabe M, Taketa K, Izumi M, Nagashima H. Association of gamma-glutamyltransferase with plasma lipoprotein and lipid-protein complex in cholestasis. Hepatogastroenterology. 1984;31:204–207
  15. Emdin M, Passino C, Donato L, Paolicchi A, Pompella A. Serum gamma-glutamyltransferase as a risk factor of ischemic stroke might be independent of alcohol consumption. Stroke. 2002;33:1163–1164
  16. Paolicchi A, Emdin E, Ghliozeni E, et al. Atherosclerotic plaques contain gamma-glutamyl transpeptidase activity. Circulation. 2004;109:1440
  17. Burnstein M, Scholnick HR, Morfin R. Rapid method for the isolation of lipoproteins from human serum by precipitation by polyanions. J Lipid Res. 1970;11:583–595
  18. Kelley JL, Kruski AW. Density gradient ultracentrifugation of serum lipoproteins in a swinging bucket rotor. Meth Enzymol. 1986;128:170–181
  19. Bentzen CLA, Marechal B, Rosenthal MA, Volk ME. Direct determination of lipoprotein cholesterol distribution with micro-scale affinity chromatography columns. Clin Chem. 1982;28:1451–1456
  20. Hanigan MH, Frierson HF. Immunohistochemical detection of gamma-glutamyl transpeptidase in normal human tissues. J Histochem Cytochem. 1996;44:1101–1108
  21. Huseby NE, Strömme JH. Practical points regarding routine determination of γ-glutamyl transferase (γ-GT) in serum with a kinetic method at 37°C. Scand J Clin Lab Invest. 1974;34:357–361
  22. Zlatkis A, Zak B, Boyle AJ. A new method for the direct determination of serum cholesterol. J Lab Clin Med. 1953;41:486–492
  23. Peterson GL. A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal Biochem. 1977;83:346–356
  24. Castaldo G, Oriani G, Lofrano MM, et al. Differential diagnosis between hepatocellular carcinoma and cirrhosis through a discriminant function based on results for serum analytes. Clin Chem. 1996;42:1263–1269
  25. Artur Y, Wellman-Bednawska M, Jacquier A, Siest G. Associations between serum gammaglutamyltransferase and apolipoproteins: relationships with hepatobiliary disease. Clin Chem. 1984;30:1318–1321

PII: S0021-9150(05)00468-5

doi: 10.1016/j.atherosclerosis.2005.07.012

Atherosclerosis
Volume 186, Issue 1 , Pages 80-85 , May 2006

Article Tools

* Image Usage & Resolution