Atherosclerosis
Volume 186, Issue 1 , Pages 86-91 , May 2006

Severe hyperlipidemia causes impaired renin–angiotensin system function in apolipoprotein E deficient mice

  • Lucia Mazzolai

      Affiliations

    • Angiology Unit, Department of Internal Medicine, University Hospital, 1011 Lausanne, Switzerland
    • Corresponding Author InformationCorresponding author. Tel.: +41 21 314 0750; fax: +41 21 314 0761.
    • ,
  • Martine Korber

      Affiliations

    • Angiology Unit, Department of Internal Medicine, University Hospital, 1011 Lausanne, Switzerland
    • ,
  • Karima Bouzourene

      Affiliations

    • Angiology Unit, Department of Internal Medicine, University Hospital, 1011 Lausanne, Switzerland
    • ,
  • Jean-François Aubert

      Affiliations

    • Angiology Unit, Department of Internal Medicine, University Hospital, 1011 Lausanne, Switzerland
    • ,
  • Jürg Nussberger

      Affiliations

    • Angiology Unit, Department of Internal Medicine, University Hospital, 1011 Lausanne, Switzerland
    • ,
  • Ivan Stamenkovic

      Affiliations

    • Department of Pathology, University Hospital, Lausanne, Switzerland
    • ,
  • Daniel Hayoz

      Affiliations

    • Angiology Unit, Department of Internal Medicine, University Hospital, 1011 Lausanne, Switzerland

Received 18 January 2005 ,Revised 24 June 2005 ,Accepted 15 July 2005.

References 

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  2. Plump AS, Smith JD, Hayek T, et al. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell. 1992;71:343–353
  3. Nakashima Y, Plump AS, Raines EW, Breslow JL, Ross R. ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb. 1994;14:133–140
  4. Ghiselli G, Schaefer EJ, Gascon P, Breser HB. Type III hyperlipoproteinemia associated with apolipoprotein E deficiency. Science. 1981;214:1239–1241
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  6. Attman PO, Alaupovic P, Samuelsson O. Lipoprotein abnormalities as a risk factor for progressive nondiabetic renal disease. Kidney Int Suppl. 1999;71:S14–S17
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  8. Fried LF, Orchard TJ, Kasiske BL. Effect of lipid reduction on the progression of renal disease: a meta-analysis. Kidney Int. 2001;59:260–269
  9. Stevenson FT, Kaysen GA. Hyperlipidemia and renal disease: the use of animal models in understanding pathophysiology and approaches to treatment. Wien Klin Wochenschr. 1999;111:307–314
  10. Majumdar A, Wheeler DC. Lipid abnormalities in renal disease. J R Soc Med. 2000;93:178–182
  11. Appel G. Lipid abnormalities in renal disease. Kidney Int. 1991;39:169–183
  12. Samuelsson O, Mulec H, Knight-Gibson C, et al. Lipoprotein abnormalities are associated with increased rate of progression of human chronic renal insufficiency. Nephrol Dial Transplant. 1997;12:1908–1915
  13. Hunsicker LG, Adler S, Caggiula A, et al. Predictors of the progression of renal disease in the Modification of Diet in Renal Disease Study. Kidney Int. 1997;51:1908–1919
  14. Muntner P, Coresh J, Smith JC, Eckfeldt J, Klag MJ. Plasma lipids and risk of developing renal dysfunction: the atherosclerosis risk in communities study. Kidney Int. 2000;58:293–301
  15. Wiesel P, Mazzolai L, Nussberger J, Pedrazzini T. Two-kidney, one clip and one-kidney, one clip hypertension in mice. Hypertension. 1997;29:1025–1030
  16. Nussberger J, Fasanella dT, Porchet M, et al. Repeated administration of the converting enzyme inhibitor cilazapril to normal volunteers. J Cardiovasc Pharmacol. 1987;9:39–44

PII: S0021-9150(05)00470-3

doi: 10.1016/j.atherosclerosis.2005.07.017

Atherosclerosis
Volume 186, Issue 1 , Pages 86-91 , May 2006

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