Atherosclerosis
Volume 188, Issue 2 , Pages 265-273 , October 2006

Simvastatin induces heat shock factor 1 in vascular endothelial cells

  • Tsuyoshi Uchiyama

      Affiliations

    • Department of Medicine and Biological Science, Gunma University Course of Medical Science, Graduate School of Medicine, Maebashi, Gunma, Japan
    • Corresponding Author InformationCorresponding author. Present address: Laboratory of Signal Transduction and Department of Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan. Tel +81 27 220 8854; fax +81 27 220 8895.
    • ,
  • Hiroyuki Atsuta

      Affiliations

    • Department of Medicine and Biological Science, Gunma University Course of Medical Science, Graduate School of Medicine, Maebashi, Gunma, Japan
    • ,
  • Toshihiro Utsugi

      Affiliations

    • Department of Medicine and Biological Science, Gunma University Course of Medical Science, Graduate School of Medicine, Maebashi, Gunma, Japan
    • ,
  • Yoshio Ohyama

      Affiliations

    • Department of Medicine and Biological Science, Gunma University Course of Medical Science, Graduate School of Medicine, Maebashi, Gunma, Japan
    • ,
  • Tetsuya Nakamura

      Affiliations

    • Department of Medicine and Biological Science, Gunma University Course of Medical Science, Graduate School of Medicine, Maebashi, Gunma, Japan
    • Clinical Investigation Unit, Gunma University Hospital, Maebashi, Gunma, Japan
    • ,
  • Akira Nakai

      Affiliations

    • Department of Biochemistry and Molecular Biology, Yamaguchi University of School of Medicine, Japan
    • ,
  • Masanori Nakata

      Affiliations

    • Division of Integrative Physiology, Department of Physiology, Jichi Medical School, Tochigi, Japan
    • ,
  • Ikuro Maruyama

      Affiliations

    • Department of Clinical Investigation, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
    • ,
  • Hideaki Tomura

      Affiliations

    • Laboratory of Signal Transduction and Department of Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan
    • ,
  • Fumikazu Okajima

      Affiliations

    • Laboratory of Signal Transduction and Department of Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan
    • ,
  • Shoichi Tomono

      Affiliations

    • School of Health Science, Faculty of Medicine, Gunma University, Maebashi, Gunma, Japan
    • ,
  • Shoji Kawazu

      Affiliations

    • Saitama Medical Center, Saitama Medical School, Saitama, Japan
    • Present address: Saitama Medical School Hospital, Health Management Center, Japan.
    • ,
  • Ryozo Nagai

      Affiliations

    • Department of Cardiovascular Disease, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    • ,
  • Masahiko Kurarbayashi

      Affiliations

    • Department of Medicine and Biological Science, Gunma University Course of Medical Science, Graduate School of Medicine, Maebashi, Gunma, Japan

Received 2 April 2005 ,Revised 1 September 2005 ,Accepted 28 October 2005.

References 

  1. Hernandez Perera O, Perez Sala D, Navarro Antolin J, et al. Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells. J Clin Invest. 1998;101:2711–2719
  2. Ito MK. The effects of converting from simvastatin to atorvastatin on plasminogen activator inhibitor type-1. J Clin Pharmacol. 2001;41:779–782
  3. Abravaya K, Phillips B, Morimoto RI. Heat shock-induced interactions of heat shock transcription factor and the human hsp70 promoter examined by in vivo footprinting. Mol Cell Biol. 1991;11:586–592
  4. Green M, Schuetz TJ, Sullivan EK, Kingston RE. A heat shock-responsive domain of human HSF1 that regulates transcription activation domain function. Mol Cell Biol. 1995;15:3354–3362
  5. Newton EM, Knauf U, Green M, Kingston RE. The regulatory domain of human heat shock factor 1 is sufficient to sense heat stress. Mol Cell Biol. 1996;16:839–846
  6. Zuo J, Rungger D, Voellmy R. Multiple layers of regulation of human heat shock transcription factor 1. Mol Cell Biol. 1995;15:4319–4330
  7. Jacquier Sarlin MR, Fuller K, Dinh Xuan AT, Richard MJ, Polla BS. Protective effects of hsp70 in inflammation. Experientia. 1994;50:1031–1038
  8. Metzler B, Abia R, Ahmad M, et al. Activation of heat shock transcription factor 1 in atherosclerosis. Am J Pathol. 2003;162:1669–1676
  9. Snoeckx LH, Cornelussen RN, Van Nieuwenhoven FA, Reneman RS, Van Der Vusse GJ. Heat shock proteins and cardiovascular pathophysiology. Physiol Rev. 2001;81:1461–1497
  10. Ishikawa K, Sugawara D, Wang X, et al. Heme oxygenase-1 inhibits atherosclerotic lesion formation in LDL-receptor knockout mice. Circ Res. 2001;88:506–512
  11. Soares MP, Usheva A, Brouard S, et al. Modulation of endothelial cell apoptosis by heme oxygenase-1-derived carbon monoxide. Antioxid Redox Signal. 2002;4:321–329
  12. Plumier JC, Ross BM, Currie RW, et al. Transgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery. J Clin Invest. 1995;95:1854–1860
  13. Garcia Cardena G, Fan R, Shah V, et al. Dynamic activation of endothelial nitric oxide synthase by Hsp90. Nature. 1998;392:821–824
  14. Pritchard KA, Ackerman AW, Gross ER, et al. Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric-oxide synthase. J Biol Chem. 2001;276:17621–17624
  15. Hsu AL, Murphy CT, Kenyon C. Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science. 2003;300:1142–1145
  16. Uchiyama T, Kurabayashi M, Ohyama Y, et al. Hypoxia induces transcription of the plasminogen activator inhibitor-1 gene through genistein-sensitive tyrosine kinase pathways in vascular endothelial cells. Arterioscler Thromb Vasc Biol. 2000;20:1155–1161
  17. Ianaro A, Ialenti A, Maffia P, Pisano B, Di Rosa M. HSF1/hsp72 pathway as an endogenous anti-inflammatory system. FEBS Lett. 2001;499:239–244
  18. Baler R, Dahl G, Voellmy R. Activation of human heat shock genes is accompanied by oligomerization, modification, rapid translocation of heat shock transcription factor HSF1. Mol Cell Biol. 1993;13:2486–2496
  19. Conway EM, Liu L, Nowakowski B, Steiner Mosonyi M, Jackman RW. Heat shock of vascular endothelial cells induces an up-regulatory transcriptional response of the thrombomodulin gene that is delayed in onset and does not attenuate. J Biol Chem. 1994;269:22804–22810
  20. Brouet A, Sonveaux P, Dessy C, et al. Hsp90 and caveolin are key targets for the proangiogenic nitric oxide-mediated effects of statins. Circ Res. 2001;89:866–873
  21. Shah V, Wiest R, Garcia Cardena G, et al. Hsp90 regulation of endothelial nitric oxide synthase contributes to vascular control in portal hypertension. Am J Physiol. 1999;277:G463–G468
  22. Kohn G, Wong HR, Bshesh K, et al. Heat shock inhibits tnf-induced ICAM-1 expression in human endothelial cells via I kappa kinase inhibition. Shock. 2002;17:91–97
  23. Soares MP, Seldon MP, Gregoire IP, et al. Heme oxygenase-1 modulates the expression of adhesion molecules associated with endothelial cell activation. J Immunol. 2004;172:3553–3563

PII: S0021-9150(05)00717-3

doi: 10.1016/j.atherosclerosis.2005.10.045

Atherosclerosis
Volume 188, Issue 2 , Pages 265-273 , October 2006

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