Atherosclerosis
Volume 188, Issue 2 , Pages 245-250 , October 2006

Low-density lipoprotein oxidized to various degrees activates ERK1/2 through Lox-1

  • Hiroyuki Tanigawa

      Affiliations

    • Department of Cardiology, Fukuoka University Hospital, Fukuoka, Japan
    • ,
  • Shin-ichiro Miura

      Affiliations

    • Department of Cardiology, Fukuoka University Hospital, Fukuoka, Japan
    • Corresponding Author InformationCorresponding author at: Department of Cardiology, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. Tel.: +81 92 801 1011; fax: +81 92 865 2692.
    • ,
  • Bo Zhang

      Affiliations

    • Department of Cardiology, Fukuoka University Hospital, Fukuoka, Japan
    • ,
  • Yoshinari Uehara

      Affiliations

    • Department of Cardiology, Fukuoka University Hospital, Fukuoka, Japan
    • ,
  • Yoshino Matsuo

      Affiliations

    • Department of Cardiology, Fukuoka University Hospital, Fukuoka, Japan
    • ,
  • Masahiro Fujino

      Affiliations

    • Department of Cardiology, Fukuoka University Hospital, Fukuoka, Japan
    • ,
  • Tatsuya Sawamura

      Affiliations

    • Department of Bioscience, National Cardiovascular Center Research Institute, Osaka, Japan
    • ,
  • Keijiro Saku

      Affiliations

    • Department of Cardiology, Fukuoka University Hospital, Fukuoka, Japan

Received 18 April 2005 ,Revised 20 October 2005 ,Accepted 26 October 2005.

References 

  1. Berliner JA, Heinecke JW. The role of oxidized lipoproteins in atherogenesis. Free Radic Biol Med. 1996;20:707–727
  2. Steinberg D. Low density lipoprotein oxidation and its pathobiological significance. J Biol Chem. 1997;272:20963–20966
  3. Kusuhara M, Chait A, Cader A, Berk BC. Oxidized LDL stimulates mitogen-activated protein kinases in smooth muscle cells and macrophages. Arterioscler Thromb Vasc Biol. 1997;17:141–148
  4. Bjorkerud B, Bjorkerud S. Contrary effects of lightly and strongly oxidized LDL with potent promotion of growth versus apoptosis on arterial smooth muscle cells, macrophages, and fibroblasts. Arterioscler Thromb Vasc Biol. 1996;16:416–424
  5. Bachem MG, Wendelin D, Schneiderhan W, et al. Depending on their concentration, oxidized low density lipoproteins stimulate extracellular matrix synthesis or induce apoptosis in human coronary artery smooth muscle cells. Clin Chem Lab Med. 1999;37:319–326
  6. Fogelman AM, Shechter I, Seager J, et al. Malondialdehyde alteration of low density lipoproteins leads to cholesteryl ester accumulation in human monocyte-macrophages. Proc Natl Acad Sci USA. 1980;77:2214–2218
  7. Steinbrecher UP, Parthasarathy S, Leake DS, Witztum JL, Steinberg D. Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids. Proc Natl Acad Sci USA. 1984;12:3883–3887
  8. Steinbrecher UP, Witztum JL, Parthasarathy S, Steinberg D. Decrease in reactive amino groups during oxidation or endothelial cell modification of LDL. Correlation with changes in receptor-mediated catabolism. Arteriosclerosis. 1987;7:135–143
  9. Steinbrecher UP. Oxidation of human low density lipoprotein results in derivatization of lysine residues of apolipoprotein B by lipid peroxide decomposition products. J Biol Chem. 1987;262:3603–3608
  10. Hoff HF, Whitaker TE, O’Neil J. Oxidation of low density lipoprotein leads to particle aggregation and altered macrophage recognition. J Biol Chem. 1992;267:602–609
  11. Mine S, Tabata T, Wada Y, et al. Oxidized low density lipoprotein-induced LFA-1-dependent adhesion and transendothelial migration of monocytes via the protein kinase C pathway. Atherosclerosis. 2002;160:281–288
  12. Zeng HH, Tu PF, Zhou K, Wang H, Wang BH, Lu JF. Antioxidant properties of phenolic diterpenes from Rosmarinus officinalis. Acta Pharmacol Sin. 2001;22:1094–1098
  13. Henriksen T, Mahoney EM, Steinberg D. Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins. Proc Natl Acad Sci USA. 1981;78:6499–6503
  14. Stocks J, Miller NE. Capillary electrophoresis to monitor the oxidative modification of low density lipoproteins. J Lipid Res. 1998;39:1305–1309
  15. Schmitz G, Mollers C, Richter V. Analytical capillary isotachophoresis of human serum lipoproteins. Electrophoresis. 1997;18:1807–1813
  16. Zorn U, Haug C, Celik E, et al. Characterization of modified low density lipoprotein subfractions by capillary isotachophoresis. Electrophoresis. 2001;22:1143–1149
  17. Chapman MJ, Laplaud PM, Luc G, et al. Further resolution of the low density lipoprotein spectrum in normal human plasma: physicochemical characteristics of discrete subspecies separated by density gradient ultracentrifugation. J Lipid Res. 1988;29:442–458
  18. Bottcher A, Schlosser J, Kronenberg F, et al. Preparative free-solution isotachophoresis for separation of human plasma lipoproteins: apolipoprotein and lipid composition of HDL subfractions. J Lipid Res. 2000;905–915
  19. Zhang B, Noda K, Saku K. Effect of atorvastatin on total lipid profiles assessed by analytical capillary isotachophoresis. Cardiology. 2003;99:211–213
  20. Kido T, Kurata H, Matsumoto A, et al. Lipoprotein analysis using agarose gel electrophoresis and differential staining of lipids. J Atheroscler Thromb. 2001;8:7–13
  21. Kojima T, Kikugawa K, Kosugi H. Is the thiobarbituric acid-reactivity of blood plasma specific to lipid peroxidation?. Chem Pharm Bull. 1990;38:3414–3418
  22. Chen H, Li D, Saldeen T, Mehta JL. Transforming growth factor-beta(1) modulates oxidatively modified LDL-induced expression of adhesion molecules: role of Lox-1. Circ Res. 2001;89:1155–1160
  23. Toshima S, Hasegawa A, Kurabayashi M, et al. Circulating oxidized low density lipoprotein levels. A biochemical risk marker for coronary heart disease. Arterioscler Thromb Vasc Biol. 2000;20:2243–2247
  24. Zhang B, Tomura H, Kuwabara A, et al. Correlation of high density lipoprotein (HDL)-associated sphingosine 1-phosphate with serum levels of HDL-cholesterol and apolipoproteins. Atherosclerosis. 2005;178:199–205
  25. Noble RP. Electrophoretic separation of plasma lipoproteins in agarose gel. J Lipid Res. 1968;9:693–700
  26. Itabe H. Oxidized low-density lipoproteins: what is understood and what remains to be clarified. Biol Pharm Bull. 2003;26:1–9
  27. Robinson MJ, Cobb MH. Mitogen-activated protein kinase pathways. Curr Opin Cell Biol. 1997;9:180–186
  28. Yang CM, Chien CS, Hsiao LD, et al. Mitogenic effect of oxidized low-density lipoprotein on vascular smooth muscle cells mediated by activation of Ras/Raf/MEK/MAPK pathway. Br J Pharmacol. 2001;132:1531–1541
  29. Sachinidis A, Seewald S, Epping P, et al. The growth-promoting effect of low-density lipoprotein may be mediated by a pertussis toxin-sensitive mitogen-activated protein kinase pathway. Mol Pharmacol. 1997;52:389–397
  30. Velarde V, Jenkins AJ, Christopher J, Lyons TJ, Jaffa AA. Activation of MAPK by modified low-density lipoproteins in vascular smooth muscle cells. J Appl Physiol. 2001;91:1412–1420
  31. Mineo C, Shaul PW. HDL stimulation of endothelial nitric oxide synthase: a novel mechanism of HDL action. Trends Cardiovasc Med. 2003;13:226–231
  32. Daugherty A, Zweifel BS, Sobel BE, Schonfeld G. Isolation of low density lipoprotein from atherosclerotic vascular tissue of Watanabe heritable hyperlipidemic rabbits. Arteriosclerosis. 1988;8:768–777

PII: S0021-9150(05)00718-5

doi: 10.1016/j.atherosclerosis.2005.10.046

Atherosclerosis
Volume 188, Issue 2 , Pages 245-250 , October 2006

Article Tools

* Image Usage & Resolution