Atherosclerosis
Volume 188, Issue 2 , Pages 292-300 , October 2006

Phosphatidylinositol-3-kinase signaling mediates vascular smooth muscle cell expression of periostin in vivo and in vitro

  • Guohong Li

      Affiliations

    • Cardiovascular Division of Internal Medicine and Cardiovascular Research Center, University of Virginia Health System, Charlottesville, VA, United States
    • Corresponding Author InformationCorresponding author. Present address: Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States. Tel.: +1 919 843 4586; fax: +1 919 843 4585.
    • ,
  • Suzanne Oparil

      Affiliations

    • Vascular Biology and Hypertension Program, University of Alabama at Birmingham, Birmingham, AL, United States
    • ,
  • John M. Sanders

      Affiliations

    • Cardiovascular Division of Internal Medicine and Cardiovascular Research Center, University of Virginia Health System, Charlottesville, VA, United States
    • ,
  • Lin Zhang

      Affiliations

    • Cardiovascular Division of Internal Medicine and Cardiovascular Research Center, University of Virginia Health System, Charlottesville, VA, United States
    • ,
  • Meiru Dai

      Affiliations

    • Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States
    • ,
  • Lan Bo Chen

      Affiliations

    • Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States
    • ,
  • Simon J. Conway

      Affiliations

    • Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, United States
    • ,
  • Coleen A. McNamara

      Affiliations

    • Cardiovascular Division of Internal Medicine and Cardiovascular Research Center, University of Virginia Health System, Charlottesville, VA, United States
    • ,
  • Ian J. Sarembock

      Affiliations

    • Cardiovascular Division of Internal Medicine and Cardiovascular Research Center, University of Virginia Health System, Charlottesville, VA, United States

Received 20 June 2005 ,Revised 17 October 2005 ,Accepted 1 November 2005.

References 

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  2. Horiuchi K, Amizuka N, Katsuura M, et al. Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta. J Bone Miner Res. 1999;14(7):1239–1249
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  14. Li G, Oparil S, Kelpke SS, et al. Fibroblast growth factor receptor-1 signaling induces osteopontin expression and vascular smooth muscle cell-dependent adventitial fibroblast migration in vitro. Circulation. 2002;106(7):854–859
  15. Li P, Oparil S, Feng W, et al. Hypoxia-responsive growth factors upregulate periostin and osteopontin expression via distinct pathways in rat pulmonary arterial smooth muscle cells. J Appl Physiol. 2004;97:1550–1558
  16. Li GH, Sanders JM, Phan ET, et al. Arterial macrophages and regenerating endothelial cells express P-selectin in atherosclerosis-prone apolipoprotein-deficient mice. Am J Pathol. 2005;167(6):1511–1518
  17. Shigematsu K, Koyama H, Olson NE, et al. Phosphatidylinositol 3-kinase signaling is important for smooth muscle cell replication after arterial injury. Arterioscler Thromb Vasc Biol. 2000;20(11):2373–2378
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  20. Dugourd C, Gervais M, Corvol P, et al. Akt is a major downstream target of PI-3-kinase involved in angiotensin II-induced proliferation. Hypertension. 2003;41:882–890
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PII: S0021-9150(05)00723-9

doi: 10.1016/j.atherosclerosis.2005.11.002

Atherosclerosis
Volume 188, Issue 2 , Pages 292-300 , October 2006

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