Atherosclerosis
Volume 191, Issue 1 , Pages 40-47, March 2007

Variance decomposition of apolipoproteins and lipids in Danish twins

  • Mogens Fenger

      Affiliations

    • Department of Clinical Biochemistry and Molecular Biology, University Hospital of Copenhagen, KBA339, Kettegaard Alle 30, 2650 Hvidovre, Denmark
    • Corresponding Author InformationCorresponding author. Tel.: +45 36322373, fax: +45 36750977.
    • ,
  • Karoline Schousboe

      Affiliations

    • The Danish Twin Registry, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    • ,
  • Thorkild I.A. Sørensen

      Affiliations

    • The Danish Epidemiology Centre, Institute of Preventive Medicine, Centre for Health and Society, Copenhagen, Denmark
    • ,
  • Kirsten O. Kyvik

      Affiliations

    • The Danish Twin Registry, Institute of Public Health, University of Southern Denmark, Odense, Denmark

Received 3 January 2006; received in revised form 25 April 2006; accepted 25 April 2006. published online 26 May 2006.

Abstract 

Objective

Twin studies are used extensively to decompose the variance of a trait, mainly to estimate the heritability of the trait. A second purpose of such studies is to estimate to what extent the non-genetic variance is shared or specific to individuals. To a lesser extent the twin studies have been used in bivariate or multivariate analysis to elucidate common genetic factors to two or more traits.

Methods and results

In the present study the variances of traits related to lipid metabolism is decomposed in a relatively large Danish twin population, including bivariate analysis to detect possible common genetic factors of the traits.

Conclusions

The heritabilities of apolipoprotein B and E, cholesterol, LDL, and high density lipoprotein (HDL) were significant in the general population, although gender-specific levels and significance were detected. Heritabilities of apolipoprotein A1, triglycerides, and very low density protein (VLDL) were only significant when the population was stratified according to gender.

Keywords: Twins, Heritability, Apolipoprotein, Lipid, Bivariate analysis

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0021-9150(06)00242-5

doi:10.1016/j.atherosclerosis.2006.04.024

Refers to corrigendum:

  • Corrigendum to “Variance decomposition of apolipoproteins and lipids in Danish twins” [Atherosclerosis 191 (2007) 40–47] , 27 June 2008

    Mogens Fenger, Karoline Schousboe, Thorkild I.A. Sørensen, Kirsten O. Kyvik
    Atherosclerosis October 2008 (Vol. 200, Issue 2, Page 451)

Atherosclerosis
Volume 191, Issue 1 , Pages 40-47, March 2007

Article Tools