Atherosclerosis
Volume 192, Issue 2 , Pages 246-252 , June 2007

Increased spatial vasa vasorum density in the proximal LAD in hypercholesterolemia—Implications for vulnerable plaque-development

  • Mario Gössl

      Affiliations

    • Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, United States
  • ,
  • Daniele Versari

      Affiliations

    • Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, United States
  • ,
  • Dallit Mannheim

      Affiliations

    • Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, United States
  • ,
  • Erik L. Ritman

      Affiliations

    • Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, United States
  • ,
  • Lilach O. Lerman

      Affiliations

    • Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, MN 55905, United States
  • ,
  • Amir Lerman

      Affiliations

    • Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, United States
    • Corresponding Author InformationCorresponding author. Tel.: +1 507 255 6670; fax: +1 507 255 1824.

Received 8 March 2006 ,Revised 19 June 2006 ,Accepted 5 July 2006.

References 

  1. Moulton KS, Heller E, Konerding MA, et al. Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice. Circulation. 1999;99:1726–1732
  2. Barger AC, Beeuwkes R, Lainey LL, Silverman KJ. Hypothesis: vasa vasorum and neovascularization of human coronary arteries. A possible role in the pathophysiology of atherosclerosis. N Engl J Med. 1984;310:175–177
  3. O’Brien ER, Garvin MR, Dev R, et al. Angiogenesis in human coronary atherosclerotic plaques. Am J Pathol. 1994;145:883–894
  4. Kolodgie FD, Gold HK, Burke AP, et al. Intraplaque hemorrhage and progression of coronary atheroma. N Engl J Med. 2003;349:2316–2325
  5. Fleiner M, Kummer M, Mirlacher M, et al. Arterial neovascularization and inflammation in vulnerable patients: early and late signs of symptomatic atherosclerosis. Circulation. 2004;110:2843–2850
  6. Moreno PR, Purushothaman KR, Fuster V, et al. Plaque neovascularization is increased in ruptured atherosclerotic lesions of human aorta: implications for plaque vulnerability. Circulation. 2004;110:2032–2038
  7. Wang JC, Normand SL, Mauri L, Kuntz RE. Coronary artery spatial distribution of acute myocardial infarction occlusions. Circulation. 2004;110:278–284
  8. Kwon HM, Sangiorgi G, Ritman EL, et al. Enhanced coronary vasa vasorum neovascularization in experimental hypercholesterolemia. J Clin Invest. 1998;101:1551–1556
  9. Gossl M, Rosol M, Malyar NM, et al. Functional anatomy and hemodynamic characteristics of vasa vasorum in the walls of porcine coronary arteries. Anat Rec A Discov Mol Cell Evol Biol. 2003;272:526–537
  10. Gossl M, Zamir M, Ritman EL. Vasa vasorum growth in the coronary arteries of newborn pigs. Anat Embryol. 2004;208(5):351–357
  11. Gossl M, Beighley PE, Malyar NM, Ritman EL. Transendothelial solute transport in the coronary vessel wall – role of vasa vasorum – A Study with Cryostatic Micro-CT. Am J Physiol Heart Circ Physiol. 2004;287(5):H2346–H2351
  12. Scanlon PJ, Faxon DP, Audet AM, et al. ACC/AHA guidelines for coronary angiography. A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines (Committee on Coronary Angiography). Developed in collaboration with the Society for Cardiac Angiography and Interventions. J Am Coll Cardiol. 1999;33:1756–1824
  13. Langheinrich AC, Michniewicz A, Sedding DG, et al. Correlation of vasa vasorum neovascularization and plaque progression in aortas of apolipoprotein E//low-density lipoprotein/ double knockout mice. Arterioscler Thromb Vasc Biol. 2005;
  14. Mofidi R, Crotty TB, McCarthy P, et al. Association between plaque instability, angiogenesis and symptomatic carotid occlusive disease. Br J Surg. 2001;88:945–950
  15. McCarthy MJ, Loftus IM, Thompson MM, et al. Angiogenesis and the atherosclerotic carotid plaque: an association between symptomatology and plaque morphology. J Vasc Surg. 1999;30:261–268
  16. Virmani R, Kolodgie FD, Burke AP, et al. Atherosclerotic plaque progression and vulnerability to rupture: angiogenesis as a source of intraplaque hemorrhage. Arterioscler Thromb Vasc Biol. 2005;25:2054–2061
  17. Bobryshev YV, Lord RS. Mapping of vascular dendritic cells in atherosclerotic arteries suggests their involvement in local immune-inflammatory reactions. Cardiovasc Res. 1998;37:799–810
  18. Gossl M, von Birgelen C, Mintz GS, et al. Volumetric assessment of ulcerated ruptured coronary plaques with three-dimensional intravascular ultrasound in vivo. Am J Cardiol. 2003;91:992–996A7
  19. Wolinsky H, Glagov S. Nature of species differences in the medial distribution of aortic vasa vasorum in mammals. Circ Res. 1967;20:409–421
  20. Gerrity RG, Natarajan R, Nadler JL, Kimsey T. Diabetes-induced accelerated atherosclerosis in swine. Diabetes. 2001;50:1654–1665
  21. Zhang L, Zalewski A, Liu Y, et al. Diabetes-induced oxidative stress and low-grade inflammation in porcine coronary arteries. Circulation. 2003;108:472–478
  22. Gossl M, Malyar NM, Rosol M, Beighley PE, Ritman EL. Impact of coronary vasa vasorum functional structure on coronary vessel wall perfusion distribution. Am J Physiol Heart Circ Physiol. 2003;285:H2019–H2026
  23. Jeremias A, Huegel H, Lee DP, et al. Spatial orientation of atherosclerotic plaque in non-branching coronary artery segments. Atherosclerosis. 2000;152:209–215
  24. Heistad DD, Marcus ML. Role of vasa vasorum in nourishment of the aorta. Blood Vessels. 1979;16:225–238
  25. Carlier S, Kakadiaris IA, Dib N, et al. Vasa vasorum imaging: a new window to the clinical detection of vulnerable atherosclerotic plaques. Curr Atheroscler Rep. 2005;7:164–169
  26. Bo WJ, McKinney WM, Bowden RL. The origin and distribution of vasa vasorum at the bifurcation of the common carotid artery with atherosclerosis. Stroke. 1989;20:1484–1487

PII: S0021-9150(06)00402-3

doi: 10.1016/j.atherosclerosis.2006.07.004

Atherosclerosis
Volume 192, Issue 2 , Pages 246-252 , June 2007