« Previous
Next »
Atherosclerosis
Volume 192, Issue 2
, Pages 253-258
, June 2007
Nicotinic acid induces secretion of prostaglandin D2 in human macrophages: An in vitro model of the niacin flush
References
- . Influence of nicotinic acid on serum cholesterol in man. Arch Biochem. 1955;54:558–559
- . Niacin therapy in atherosclerosis. Curr Opin Lipidol. 2004;15:659–665
- Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin. J Am Coll Cardiol. 1986;8:1245–1255
- Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med. 2001;345:1583–1592
- . Varying cost and free nicotinic acid content in over-the-counter niacin preparations for dyslipidemia. Ann Intern Med. 2003;139:996–1002
- . Tolerance to nicotinic acid flushing. Clin Pharmacol Ther. 1991;50:66–70
- . Efficacy and safety of controlled-release niacin in dyslipoproteinemic veterans. Ann Intern Med. 1994;121:252–258
- . Release of markedly increased quantities of prostaglandin D2 in vivo in humans following the administration of nicotinic acid. Prostaglandins. 1989;38:263–274
- . Identification of skin as a major site of prostaglandin D2 release following oral administration of niacin in humans. J Invest Dermatol. 1992;98:812–815
- . The major source of endogenous prostaglandin D2 production is likely antigen-presenting cells. Localization of glutathione-requiring prostaglandin D synthetase in histiocytes, dendritic, and Kupffer cells in various rat tissues. J Immunol. 1989;143:2982–2989
- . Molecular cloning and characterization of the human prostanoid DP receptor. J Biol Chem. 1995;270:18910–18916
- Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans. Proc Natl Acad Sci USA. 2006;103:6682–6687
- . Formation of eicosanoids during differentiation of THP-1 cells. Adv Exp Med Biol. 1997;407:491–495
- . Human peritoneal macrophages in culture: a model for studying inflammatory disorders in vitro. Clin Exp Med. 2003;3:15–19
- . Differences in metabolism of time-release and unmodified nicotinic acid: explanation of the differences in hypolipidemic action?. Metabolism. 1992;41:879–881
- . Nonsteroidal antiinflammatory drugs inhibit cyclooxygenase-2 enzyme activity but not mRNA expression in human macrophages. Biochem Biophys Res Commun. 1996;225:896–900
- . Effect of two aspirin pretreatment regimens on niacin-induced cutaneous reactions. J Gen Intern Med. 1997;12:591–596
- . Stimulation of CD36 and the key effector of reverse cholesterol transport ATP-binding cassette A1 in monocytoid cells by niacin. Biochem Pharmacol. 2004;67:411–419
- . 15-Deoxy-delta12,14-PGJ2: endogenous PPARgamma ligand or minor eicosanoid degradation product?. J Clin Invest. 2003;112:828–830
- . Niacin induces PPARgamma expression and transcriptional activation in macrophages via HM74 and HM74a-mediated induction of prostaglandin synthesis pathways. Biochem Pharmacol. 2006;71:646–656
- . Enhancement of arachidonic acid signaling pathway by nicotinic acid receptor HM74A. Biochem Biophys Res Commun. 2006;
- GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing. J Clin Invest. 2005;115:3634–3640
- . Macrophages and dendritic cells constitute a major subpopulation of cells in the mouse dermis. J Invest Dermatol. 2004;123:876–879
- . Heterogeneous populations of class II MHC+ cells in human dermal cell suspensions Identification of a small subset responsible for potent dermal antigen-presenting cell activity with features analogous to Langerhans cells. J Immunol. 1993;158:4067–4080
- . Studies on the relation between mobilization of free fatty acids and energy metabolism in man: effects of norepinephrine and nicotinic acid. Metabolism. 1964;13:1402–1412
☆ Presented, in part at the western meetings of the American Federation for Medical Research in Carmel California, 2/2005 and the International Eicosinoid Conference in San Francisco, CA 9/2005.
PII: S0021-9150(06)00412-6
doi: 10.1016/j.atherosclerosis.2006.07.014
© 2006 Elsevier Ireland Ltd. All rights reserved.
« Previous
Next »
Atherosclerosis
Volume 192, Issue 2
, Pages 253-258
, June 2007
