Atherosclerosis
Volume 193, Issue 2 , Pages 335-342 , August 2007

The effect of interleukin-10 knock-out and overexpression on neointima formation in hypercholesterolemic APOE*3-Leiden mice

  • Daniel Eefting

      Affiliations

    • Gaubius Laboratory, TNO-Quality of Life, Leiden, The Netherlands
    • Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands
    • These authors contributed equally to this work.
  • ,
  • Abbey Schepers

      Affiliations

    • Gaubius Laboratory, TNO-Quality of Life, Leiden, The Netherlands
    • Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands
    • These authors contributed equally to this work.
  • ,
  • Margreet R. De Vries

      Affiliations

    • Gaubius Laboratory, TNO-Quality of Life, Leiden, The Netherlands
  • ,
  • Nuno M.M. Pires

      Affiliations

    • Gaubius Laboratory, TNO-Quality of Life, Leiden, The Netherlands
    • Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
  • ,
  • Jos M. Grimbergen

      Affiliations

    • Gaubius Laboratory, TNO-Quality of Life, Leiden, The Netherlands
  • ,
  • Tonny Lagerweij

      Affiliations

    • Gaubius Laboratory, TNO-Quality of Life, Leiden, The Netherlands
  • ,
  • Lex M. Nagelkerken

      Affiliations

    • Gaubius Laboratory, TNO-Quality of Life, Leiden, The Netherlands
  • ,
  • Pascalle S. Monraats

      Affiliations

    • Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
  • ,
  • J. Wouter Jukema

      Affiliations

    • Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
  • ,
  • J. Hajo van Bockel

      Affiliations

    • Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands
  • ,
  • Paul H.A. Quax

      Affiliations

    • Gaubius Laboratory, TNO-Quality of Life, Leiden, The Netherlands
    • Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands
    • Corresponding Author InformationCorresponding author at: Gaubius Laboratory, TNO-Quality of Life, Department of Biomedical Research, Leiden University Medical Center, Zernikedreef 9, P.O. Box 2215, 2301 CE Leiden, The Netherlands. Tel.: +31 715181509; fax: +31 715181904.

Received 12 May 2006 ,Revised 22 September 2006 ,Accepted 27 September 2006.

References 

  1. Ross R. Atherosclerosis—an inflammatory disease. N Engl J Med. 1999;340:115–126
  2. Serrano CV, Ramires JA, Venturinelli M, et al. Coronary angioplasty results in leukocyte and platelet activation with adhesion molecule expression. Evidence of inflammatory responses in coronary angioplasty. J Am Coll Cardiol. 1997;29:1276–1283
  3. Welt FG, Rogers C. Inflammation and restenosis in the stent era. Arterioscler Thromb Vasc Biol. 2002;22:1769–1776
  4. Monraats PS, Pires NM, Schepers A, et al. Tumor necrosis factor-alpha plays an important role in restenosis development. FASEB J. 2005;19:1998–2004
  5. de Waal MR, Yssel H, Roncarolo MG, Spits H, de Vries JE. Interleukin-10. Curr Opin Immunol. 1992;4:314–320
  6. Mallat Z, Besnard S, Duriez M, et al. Protective role of interleukin-10 in atherosclerosis. Circ Res. 1999;85:e17–e24
  7. Mallat Z, Heymes C, Ohan J, Faggin E, Leseche G, Tedgui A. Expression of interleukin-10 in advanced human atherosclerotic plaques: relation to inducible nitric oxide synthase expression and cell death. Arterioscler Thromb Vasc Biol. 1999;19:611–616
  8. Feldman LJ, Aguirre L, Ziol M, et al. Interleukin-10 inhibits intimal hyperplasia after angioplasty or stent implantation in hypercholesterolemic rabbits. Circulation. 2000;101:908–916
  9. Zimmerman MA, Reznikov LL, Raeburn CD, Selzman CH. Interleukin-10 attenuates the response to vascular injury. J Surg Res. 2004;121:206–213
  10. Mazighi M, Pelle A, Gonzalez W, et al. IL-10 inhibits vascular smooth muscle cell activation in vitro and in vivo. Am J Physiol Heart Circ Physiol. 2004;287:H866–H871
  11. van den Maagdenberg AM, Hofker MH, Krimpenfort PJ, et al. Transgenic mice carrying the apolipoprotein E3-Leiden gene exhibit hyperlipoproteinemia. J Biol Chem. 1993;268:10540–10545
  12. Lardenoye JH, Delsing DJ, de Vries MR, et al. Accelerated atherosclerosis by placement of a perivascular cuff and a cholesterol-rich diet in ApoE*3Leiden transgenic mice. Circ Res. 2000;87:248–253
  13. Pires NM, Schepers A, van der Hoeven BL, et al. Histopathologic alterations following local delivery of dexamethasone to inhibit restenosis in murine arteries. Cardiovasc Res. 2005;68:415–424
  14. McMahon JM, Wells DJ. Electroporation for gene transfer to skeletal muscles: current status. BioDrugs. 2004;18:155–165
  15. Andre F, Mir LM. DNA electrotransfer: its principles and an updated review of its therapeutic applications. Gene Ther. 2004;11(Suppl. 1):S33–S42
  16. van Vlijmen BJ, van den Maagdenberg AM, Gijbels MJ, et al. Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice. J Clin Invest. 1994;93:1403–1410
  17. Kuhn R, Lohler J, Rennick D, Rajewsky K, Muller W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell. 1993;75:263–274
  18. Lardenoye JH, de Vries MR, Lowik CW, et al. Accelerated atherosclerosis and calcification in vein grafts: a study in APOE*3 Leiden transgenic mice. Circ Res. 2002;91:577–584
  19. Moroi M, Zhang L, Yasuda T, et al. Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice. J Clin Invest. 1998;101:1225–1232
  20. Nitta Y, Tashiro F, Tokui M, et al. Systemic delivery of interleukin 10 by intramuscular injection of expression plasmid DNA prevents autoimmune diabetes in nonobese diabetic mice. Hum Gene Ther. 1998;9:1701–1707
  21. McMahon JM, Signori E, Wells KE, Fazio VM, Wells DJ. Optimisation of electrotransfer of plasmid into skeletal muscle by pretreatment with hyaluronidase—increased expression with reduced muscle damage. Gene Ther. 2001;8:1264–1270
  22. Pillon A, Servant N, Vignon F, Balaguer P, Nicolas JC. In vivo bioluminescence imaging to evaluate estrogenic activities of endocrine disrupters. Anal Biochem. 2005;340:295–302
  23. Palmaz JC. Intravascular stents in the last and the next 10 years. J Endovasc Ther. 2004;11(Suppl. 2):II200–II206
  24. Caligiuri G, Rudling M, Ollivier V, et al. Interleukin-10 deficiency increases atherosclerosis, thrombosis, and low-density lipoproteins in apolipoprotein E knockout mice. Mol Med. 2003;9:10–17
  25. Namiki M, Kawashima S, Yamashita T, et al. Intramuscular gene transfer of interleukin-10 cDNA reduces atherosclerosis in apolipoprotein E-knockout mice. Atherosclerosis. 2004;172:21–29
  26. Yoshioka T, Okada T, Maeda Y, et al. Adeno-associated virus vector-mediated interleukin-10 gene transfer inhibits atherosclerosis in apolipoprotein E-deficient mice. Gene Ther. 2004;11:1772–1779
  27. der Thusen JH, Kuiper J, Fekkes ML, De Vos P, Van Berkel TJ, Biessen EA. Attenuation of atherogenesis by systemic and local adenovirus-mediated gene transfer of interleukin-10 in LDLr−/− mice. FASEB J. 2001;15:2730–2732
  28. Mallat Z, Tedgui A. Immunomodulation to combat atherosclerosis: the potential role of immune regulatory cells. Expert Opin Biol Ther. 2004;4:1387–1393
  29. Monraats PS, Pires NM, Agema WR, et al. Genetic inflammatory factors predict restenosis after percutaneous coronary interventions. Circulation. 2005;112:2417–2425
  30. Koss K, Satsangi J, Fanning GC, Welsh KI, Jewell DP. Cytokine (TNF alpha, LT alpha and IL-10) polymorphisms in inflammatory bowel diseases and normal controls: differential effects on production and allele frequencies. Genes Immun. 2000;1:185–190

PII: S0021-9150(06)00589-2

doi: 10.1016/j.atherosclerosis.2006.09.032

Atherosclerosis
Volume 193, Issue 2 , Pages 335-342 , August 2007