Atherosclerosis
Volume 195, Issue 1 , Pages 7-16, November 2007

Statin-associated adverse effects beyond muscle and liver toxicity

  • D.N. Kiortsis

      Affiliations

    • Laboratory of Physiology, Medical School, University of Ioannina, Ioannina, Greece
    • ,
  • T.D. Filippatos

      Affiliations

    • Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
    • ,
  • D.P. Mikhailidis

      Affiliations

    • Department of Clinical Biochemistry (Vascular Disease Prevention Clinics), Royal Free & University College Medical School, London, UK
    • ,
  • M.S. Elisaf

      Affiliations

    • Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
    • Corresponding Author InformationCorresponding author. Tel.: +30 26510 97509; fax: +30 26510 97016.
    • ,
  • E.N. Liberopoulos

      Affiliations

    • Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece

Received 5 August 2006; received in revised form 17 September 2006; accepted 2 October 2006. published online 10 November 2006.

Abstract 

Randomized controlled trials with 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have consistently demonstrated significant reductions in cardiovascular morbidity and mortality. Statins are currently the most widely used drugs in many countries. The most important adverse effects are associated with muscle and liver toxicity. However, with increased use and dose of statins and their over-the-counter availability in some countries more cases of other rare side effects may be seen in clinical practice. In the present article we review the literature concerning the statin-related adverse effects other than muscle and liver injury and we provide insight into their clinical revelance and possible underlying mechanisms.

Keywords: HMG-CoA reductase inhibitors, Statins, Myopathy, Side effects, Adverse effects, Cancer, Neuropathy, Renal effects

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PII: S0021-9150(06)00603-4

doi:10.1016/j.atherosclerosis.2006.10.001

Atherosclerosis
Volume 195, Issue 1 , Pages 7-16, November 2007

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