Atherosclerosis
Volume 195, Issue 1 , Pages 66-74 , November 2007

Reduced atherosclerosis in chow-fed mice expressing high levels of a catalytically inactive human hepatic lipase

Received 17 April 2006 ,Revised 11 October 2006 ,Accepted 1 December 2006.

References 

  1. Brunzell JD, Deeb SS. Familial lipoprotein lipase deficiency, apoC-II deficiency and hepatic lipase deficiency. In:  Scriver CR, et al. editor. The metabolic and molecular bases of inherited disease. New York: McGraw-Hill Medical Publishing Company; 2001;p. 2789–2816
  2. Jansen H, Verhoeven AJM, Sijbrands EJG. Hepatic lipase: a pro-or anti-atherogenic protein?. J Lipid Res. 2002;43:1352–1362
  3. Dichek HL, et al. Overexpression of hepatic lipase in transgenic mice decreases apolipoprotein B-containing and high density lipoproteins. J Biol Chem. 1998;273:1896–1903
  4. Santamarina-Fojo S, Haudenschild C, Amar M. The role of hepatic lipase in lipoprotein metabolism and atherosclerosis. Curr Opin Lipidol. 1998;9:211–219
  5. Connelly PW. The role of hepatic lipase in lipoprotein metabolism. Clin Chim Acta. 1999;286:243–255
  6. Krapp A, et al. Hepatic lipase mediates the uptake of chylomicrons and β-VLDL into cells via the LDL receptor-related protein. J Lipid Res. 1996;37:926–936
  7. Ji Z-S, et al. Heparan sulfate proteoglycans participate in hepatic lipase- and apolipoprotein E-mediated binding and uptake of plasma lipoproteins, including high density lipoproteins. J Biol Chem. 1997;272:31285–31292
  8. Amar MJ, et al. Hepatic lipase facilitates the selective uptake of cholesteryl esters from remnant lipoproteins in apoE-deficient mice. J Lipid Res. 1998;39:2436–2442
  9. Swarnakar S, Temel RE, Connelly MA, Azhar S, Williams DL. Scavenger receptor class B, type I, mediates selective uptake of low density lipoprotein cholesteryl ester. J Biol Chem. 1999;274:29733–29739
  10. Connelly MA, Williams DL. SR-B1 and cholesterol uptake into steroidogenic cells. Trends Endocrinol Metab. 2003;14:467–472
  11. Santamarina-Fojo S, Gonzalez-Navarro H, Freeman L, Wagner E, Nong Z. Hepatic lipase, lipoprotein metabolism, and atherogenesis. Arterioscler Thromb Vase Biol. 2004;24:1750–1758
  12. Krauss RM. Relationship of intermediate and low-density lipoprotein subspecies to risk of coronary artery disease. Am Heart J. 1987;113:578–582
  13. Zambon A, Austin MA, Brown BG, Hokanson JE, Brunzell JB. Effect of hepatic lipase on LDL in normal men and those with coronary artery disease. Arterioscler Thromb Vasc Biol. 1993;13:147–153
  14. Kuusi T, Saarinen P, Nikkilä EA. Evidence for the role of hepatic endothelial lipase in the metabolism of plasma high density lipoprotein2 in man. Atherosclerosis. 1980;36:589–593
  15. Deeb SS, Zambon A, Carr MC, Ayyobi AF, Brunzell JB. Hepatic lipase and dyslipidemia: interactions among genetic variants, obesity, gender and diet. J Lipid Res. 2003;44:1279–1286
  16. Mezdour H, et al. Hepatic lipase deficiency increases plasma cholesterol but reduces susceptibility to atherosclerosis in apolipoprotein E-deficient mice. J Biol Chem. 1997;272:13570–13575
  17. Nong Z, Gonzalez-Navarro H, Amar M, et al. Hepatic lipase expression in macrophages contributes to atherosclerosis in apoE-deficient and LCAT-transgenic mice. J Clin Invest. 2003;112:367–378
  18. Karackattu SL, Trigatti B, Krieger M. Hepatic lipase deficiency delays atherosclerosis, myocardial infarction, and cardiac dysfunction and extends lifespan in SR-BI/apolipoprotein E double knockout mice. Arterioscler Thromb Vase Biol. 2006;26:548–554
  19. Shirai K, Barnhart RL, Jackson RL. Hydrolysis of human plasma high density lipoprotein2-phospholipids and triglycerides by hepatic lipase. Biochem Biophys Res Commun. 1981;100:591–599
  20. Barrans A, et al. Hepatic lipase induces the formation of pre-β1 high density lipoprotein (HDL) from triacylglylcerol-rich HDL2. A study comparing liver perfusion to in vitro incubation with lipases. J Biol Chem. 1994;269:11572–11577
  21. Busch SJ, et al. Human hepatic triglyceride lipase expression reduces high density lipoprotein and aortic cholesterol in cholesterol-fed transgenic mice. J Biol Chem. 1994;269:16376–16382
  22. Dichek HL, Qian K, Agrawal N. Divergent effects of the catalytic and bridging functions of hepatic lipase on atherosclerosis. Arterioscler Thromb Vasc Biol. 2004;24:1696–1702
  23. Gaw A, Mancini FP, Ishibashi S. Rapid genotyping of low density lipoprotein receptor knockout mice using a polymerase chain reaction technique. Lab Anim. 1995;29(4):447–449
  24. Dichek HL, Qian K, Agrawal N. The bridging function of hepatic lipase clears plasma cholesterol in LDL receptor-deficient “apoB-48-only” and “apoB- 100-only” mice. J Lipid Res. 2004;45:551–560
  25. Véniant MM, et al. Susceptibility to atherosclerosis in mice expressing exclusively apolipoprotein B48 or apolipoprotein B100. J Clin Invest. 1997;100:180–188
  26. Rossmeisl M, Rim JS, Koza RA, Kozak LP. Variation in Type 2 Diabetes-related traits in mouse strains susceptible to diet-induced obesity. Diabetes. 2003;52:1958–1966
  27. Salmon DM, Flatt JP. Effect of dietary fat on the incidence of obesity among ad libitum fed mice. Int J Obesity. 1985;9:443–449
  28. Folch J, Lees M, Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem. 1957;226:497–509
  29. Brown MS, Faust JR, Goldstein JL. Role of the low density lipoprotein receptor in regulating the content of free and esterified cholesterol in human fibroblasts. J Clin Invest. 1975;55:783–793
  30. Horobi RW. Conn's biological stains: a handbook of dyes, stains, and fluorochromes for use in biology and medicine. Bios Scientific Publisher; 2002;
  31. Bjorkhem I, Boberg KM, Leitersdorf E. Inborn errors in bile acid biosynthesis and storage of sterols other than cholesterol. In:  Scriver CR, et al. editor. The metabolic and molecular bases of inherited disease. New York: McGraw-Hill Medical Publishing Company; 2001;p. 2961–2988
  32. Dichek HL, Agrawal N, El Andaloussi N, Qian K. Attenuated corticosterone response to chronic ACTH stimulation in hepatic lipase-deficient mice: evidence for a role for hepatic lipase in adrenal physiology. Am J Physiol Endocrinol Metab. 2006;290:E908–E915
  33. Dichek HL, et al. Hepatic lipase overexpression lowers remnant and LDL levels by a noncatalytic mechanism in LDL receptor-deficient mice. J Lipid Res. 2001;42:201–210
  34. Chappell DA, Medh JD. Receptor-mediated mechanisms of lipoprotein remnant catabolism. Prog Lipid Res. 1998;37:393–422
  35. Kowal RC, et al. Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins. Proc Natl Acad Sci USA. 1989;86:5810–5814
  36. Ji Z-S, et al. Secretion-capture role for apolipoprotein E in remnant lipoprotein metabolism involving cell surface heparan sulfate proteoglycans. J Biol Chem. 1994;269:2764–2772
  37. Kounnas MZ, et al. The cellular internalization and degradation of hepatic lipase is mediated by low density lipoprotein receptor-related protein and requires cell surface proteoglycans. J Biol Chem. 1995;270:9307–9312
  38. Chua CC, Rahimi N, Forsten-Williams K, Nugent M. Heparan sulfate proteogly cans function as receptors for fibroblast growth factor-2 activation of extracellular signal-regulated kinases 1 and 2. Circ Res. 2004;94:316–323
  39. Zhang G, Cai X, Lopez-Guisa JM, Collins SJ, Eddy AA. Mitogenic signaling of urokinase receptor-deficient kidney fibroblasts: actions of an alternative urokinase receptor and LDL receptor-related protein. J Am Soc Nephrol. 2004;15:2090–2102
  40. Gonzalez-Navarro H, Nong Z, Amar MJA, et al. The ligand-binding function of hepatic lipase modulates the development of atherosclerosis in transgenic mice. J Biol Chem. 2004;279:45312–45321

PII: S0021-9150(06)00745-3

doi: 10.1016/j.atherosclerosis.2006.12.002

Atherosclerosis
Volume 195, Issue 1 , Pages 66-74 , November 2007