Atherosclerosis
Volume 199, Issue 1 , Pages 154-161 , July 2008

Evidence for persistent Chlamydia pneumoniae infection of human coronary atheromas

  • Nicole Borel

      Affiliations

    • Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 268, CH-8057 Zurich, Switzerland
    • Corresponding Author InformationCorresponding author. Tel.: +41 44 635 8551; fax: +41 44 635 8934.
    • ,
  • James T. Summersgill

      Affiliations

    • Division of Infectious Diseases, Department of Medicine, University of Louisville, 500 South Preston Street, Louisville, KY 40292, USA
    • Department of Microbiology and Immunology, University of Louisville, Louisville, KY 40292, USA
    • ,
  • Sanghamitra Mukhopadhyay

      Affiliations

    • Division of Infectious Diseases, Department of Medicine, University of Louisville, 500 South Preston Street, Louisville, KY 40292, USA
    • Present address: Biological Defense Research Directorate, Naval Medical Research Center, 12300 Washington Avenue, Rockville, MD 20852, USA.
    • ,
  • Richard D. Miller

      Affiliations

    • Department of Microbiology and Immunology, University of Louisville, Louisville, KY 40292, USA
    • ,
  • Julio A. Ramirez

      Affiliations

    • Division of Infectious Diseases, Department of Medicine, University of Louisville, 500 South Preston Street, Louisville, KY 40292, USA
    • ,
  • Andreas Pospischil

      Affiliations

    • Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 268, CH-8057 Zurich, Switzerland

Received 31 July 2007 ,Revised 6 September 2007 ,Accepted 18 September 2007.

References 

  1. Kalayoglu MV, Libby P, Byrne GI. Chlamydia pneumoniae as an emerging risk factor in cardiovascular disease. JAMA. 2002;288:2724–2731
  2. Ramirez JA. Isolation of Chlamydia pneumoniae from the coronary artery of a patient with coronary atherosclerosis. Ann Intern Med. 1996;125:979–982
  3. Hogan RJ, Mathews SA, Mukhopadhyay S, Summersgill JT, Timms P. Chlamydial persistence: beyond the biphasic paradigm. Infect Immun. 2004;72:1843–1855
  4. Summersgill JT, Sahney NN, Gaydos CA, Quinn TC, Ramirez JA. Inhibition of Chlamydia pneumoniae growth in HEp-2 cells pretreated with gamma interferon and tumor necrosis factor alpha. Infect Immun. 1995;36:2801–2803
  5. Mehta SJ, Miller RD, Ramirez JA, Summersgill JT. Inhibition of Chlamydia pneumoniae replication in HEp-2 cells by interferon-γ: role of tryptophan catabolism. J Infect Dis. 1998;177:1326–1331
  6. Pantoja LG, Miller RD, Ramirez JA, Molestina RE, Summersgill JT. Characterization of Chlamydia pneumoniae persistence in HEp-2 cells treated with gamma interferon. Infect Immun. 2001;69:7927–7932
  7. Molestina RE, Klein JB, Miller RD, Pierce WH, Ramirez JA, Summersgill JT. Proteomic analysis of differentially expressed Chlamydia pneumoniae genes during persistent infection of HEp-2 cells. Infect Immun. 2002;70:2976–2981
  8. Mukhopadhyay S, Miller RD, Sullivan ED, et al. Protein expression profiles of Chlamydia pneumoniae in models of persistence versus those of heat shock stress response. Infect Immun. 2006;74:3853–3863
  9. Borel N, Mukhopadhyay S, Kaiser C, et al. Tissue MicroArray (TMA) analysis of normal and persistent Chlamydophila pneumoniae infection. BMC Infect Dis. 2006;19(6):152
  10. Merighi A. Post-embedding electron microscopic immunocytochemistry. In:  Polak JM,  Priestley JV editor. Electron microscopic immunocytochemistry: principles and practice. New York: University Press; 1992;p. 51–87
  11. Ross R. Atherosclerosis—an inflammatory disease. N Engl J Med. 1999;340:115–126
  12. Gieffers J, Fullgraf H, Jahn J, et al. Chlamydia pneumoniae infection in circulating human monocytes is refractory to antibiotic treatment. Circulation. 2001;103:351–356
  13. Andraws R, Berger JS, Brown DL. Effects of antibiotic therapy on outcomes of patients with coronary artery disease: a meta-analysis of randomized controlled trials. JAMA. 2005;293:2641–2647

PII: S0021-9150(07)00566-7

doi: 10.1016/j.atherosclerosis.2007.09.026

Atherosclerosis
Volume 199, Issue 1 , Pages 154-161 , July 2008

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