Atherosclerosis
Volume 199, Issue 2 , Pages 362-367 , August 2008

Effect of homocysteine-lowering therapy on arterial elasticity and metabolic parameters in metformin-treated diabetic patients

  • M. Mashavi

      Affiliations

    • Department of Medicine, Wolfson Medical Center, Tel Aviv, Israel
    • Department of Diabetes, Wolfson Medical Center, Tel Aviv, Israel
    • Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
  • ,
  • R. Hanah

      Affiliations

    • Department of Medicine, Wolfson Medical Center, Tel Aviv, Israel
  • ,
  • M. Boaz

      Affiliations

    • Department of Epidemiology and Statistics, Wolfson Medical Center, Tel Aviv, Israel
  • ,
  • D. Gavish

      Affiliations

    • Department of Medicine, Wolfson Medical Center, Tel Aviv, Israel
    • Bruner Institute for Cardiovascular Research, Tel Aviv University, Tel Aviv, Israel
    • Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
  • ,
  • Z. Matas

      Affiliations

    • Department of Biochemistry, Wolfson Medical Center, Tel Aviv, Israel
  • ,
  • A. Fux

      Affiliations

    • Department of Biochemistry, Wolfson Medical Center, Tel Aviv, Israel
  • ,
  • M. Shargorodsky

      Affiliations

    • Department of Diabetes, Wolfson Medical Center, Tel Aviv, Israel
    • Department of Endocrinology, Wolfson Medical Center, Tel Aviv, Israel
    • Bruner Institute for Cardiovascular Research, Tel Aviv University, Tel Aviv, Israel
    • Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    • Corresponding Author InformationCorresponding author at: Wolfson Medical Center, POB 5, Holon 58100, Israel. Tel.: +972 3 5028614; fax: +972 3 5032693.

Received 23 July 2007 ,Revised 25 October 2007 ,Accepted 28 November 2007.

References 

  1. UK Prospective Diabetes Study (UKPDS) Group . Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet. 1998;352:854–865
  2. Kraemer de Aguiar LG, Bahia LR, Villela N, et al. Metformin improves endothelial vascular reactivity in first-degree relatives of type 2 diabetic patients with metabolic syndrome and normal glucose tolerance. Diabetes Care. 2006;29:1083–1089
  3. Jager J, Kooy A, Lehert PH, et al. Effect of short-term treatment with metformin on markers of endothelial function and inflammatory activity in type 2 diabetes mellitus: a randomized, placebo-controlled trial. J Intern Med. 2005;257:100–109
  4. Grant PJ. Beneficial effects of metformin on haemostasis and vascular function in man. Diab Med. 2003;29:6S44–6S52
  5. Nygard O, Nordrchaug JE, Refsum H, et al. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med. 1997;337:230–236
  6. Hoogeveen E, Konstense PJ, Beks PJ, et al. Hyperhomocysteinemia is associated with increased risk of cardiovascular disease, especially in non-insulin-dependent diabetes mellitus: a population-based study. Arterioscler Thromb Vasc Biol. 1998;18:133–138
  7. van Popele NM, Grobbee DE, Bots ML, et al. Association between arterial stiffness and atherosclerosis: the Rotterdam Study. Stroke. 2001;32:454–460
  8. Blacher J, Guerin AP, Pannier B, et al. Impact of aortic stiffness on survival in end-stage renal disease. Circulation. 1999;99:2434–2439
  9. Laurent S, Boutouyrie P, Asmar R, et al. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension. 2001;37:1236–1241
  10. Cruickshank K, Riste L, Anderson SG, et al. Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance. An integrated index of vascular function?. Circulation. 2002;106:2085–2090
  11. Zieman SJ, Melenovsky V, Kass DA. Mechanisms, pathophysiology, and therapy of arterial stiffness. Arterioscler Thromb Vasc Biol. 2005;25:932–943
  12. Giannattasio C, Mancia G. Arterial distensibility in humans. Modulating mechanisms, alterations in diseases and effects of treatment. J Hypertens. 2002;20:1889–1899
  13. Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419
  14. Cohn JN, Finkelstein S, McVeigh G, et al. Non-invasive pulse wave analysis for the detection of arterial vascular disease. Hypertension. 1995;26:503–508
  15. Zimlichman R, Shargorodsky M, Boaz M, et al. Determination of arterial compliance using blood pressure waveform analysis with the CR-2000 system. Am J Hypertens. 2005;18:65–71
  16. McVeigh GE, Burns DE, Finkelstein SM, et al. Reduced vascular compliance as a marker for essential hypertension. Am J Hypertens. 1991;4:245–257
  17. Shargorodsky M, Fleed A, Boas M, Gavish D, Zimlichman R. The effect of rapid weight loss induced by laparoscopic adjustable gastric banding on arterial stiffness, metabolic and inflammatory parameters in patients with morbid obesity. Int J Obes. 2006;
  18. Grant PJ. Beneficial effects of metformin on haemostasis and vascular function in man. Diab Med. 2003;29:6s44–6s52
  19. Katakam PVG, Ujhelyi MR, Hoenig M, Miller AW. Metformin improves vascular function in insulin-resistant rats. Hypertension. 2000;35:108–112
  20. Mather KJ, Verma S, Anderson TJ. Improved endothelial function with metformin in type 2 diabetes mellitus. J Am Coll Cardiol. 2001;37:1344–1350
  21. Vitale C, Mercuro G, Cornoldi A, et al. Metformin improves endothelial function in patients with metabolic syndrome. J Intern Med. 2005;258:250–256
  22. Wulffele MG, Kooy A, Lehert P, et al. Effect of short-term treatment with metformin on serum concentration of homocysteine, folate and vitamin B12 in diabetes mellitus: a randomized, placebo-controlled trial. J Intern Med. 2004;255(2):302–303
  23. Hoogeveen EK, Kostense PJ, Jakobs C, et al. Does metformin increase the serum total homocysteine level in non-insulin-dependent diabetes mellitus?. J Intern Med. 1997;242:389–394
  24. Chico A, Perez A, Cordoba A, et al. Plasma homocysteine is related to albumin excretion rate in patients with diabetes mellitus: a new link between diabetic nephropathy and cardiovascular disease?. Diabetologia. 1998;41:684–693
  25. Malinow MR, Nieto FJ, Szklo M, Chambless LE, Bond G. Carotid artery intimal–medial wall thickening and plasma homocysteine in asymptomatic adults. Circulation. 1993;87:1107–1113
  26. Tayama J, Munakata M, Yoshinaga K, Toyota T. Higher plasma homocysteine concentration is associated with more advanced systemic arterial stiffness and greater blood pressure response to stress in hypertensive patients. Hypertens Res. 2006;29:403–409
  27. Celermajer DS, Sorensen K, Ryalls M, et al. Impaired endothelial function occurs in the systemic arteries of children with homozygous homocystinuria but not in their heterozygous parents. J Am Coll Cardiol. 1993;22:854–858
  28. Chambers JC, Obeid O, McGregor A, et al. The relationship between hyperhomocysteinemia and endothelial function is concentration-dependent, and present even at physiological levels. Circulation. 1998;98:191–192
  29. Nestel PJ, Chronopoulos A, Cehun M. Arterial stiffness is rapidly induced by raising the plasma homocysteine concentration with methionine. Atherosclerosis. 2003;171:83–86
  30. Welch GN, Loscalzo J. Homocysteine and atherothrombosis. N Engl J Med. 1998;338:1042–1050
  31. Charpiot P, Bescond A, Augier T, et al. Hyperhomocysteinemia induces elastolysis in miniping arteries: structural consequences, arterial site specificity and effect of captopril-hydrochlorothiazide. Matrix Biol. 1998;17:559–574
  32. Stamler JS, Osborne JA, Jaraki O, et al. Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen. J Clin Invest. 1993;91:308–318
  33. Tawakol A, Omland T, Gerhard M, Wu JT, Creager MA. Hyperhomocysteinemia is associated with impaired endothelium-dependant vasodilatation in human. Circulation. 1997;95:1119–1121
  34. Buysschaert M, Dramais AS, Wallemacq PE, Hermans MP. Hyperhomocysteinemia in type 2 diabetes. Relationship to macroangiopathy, nephropathy and insulin resistance. Diab Care. 2000;23:1816–1822
  35. Grey Y, Bratteli C, Glaser SP, et al. Reduced small artery but not large artery elasticity is an independent risk marker for cardiovascular events. Am J Hypertens. 2003;16:265–269
  36. McVeigt GE, Allen PB, Morgan DR, Hanratty CG, Silke B. Nitric oxide modulation of blood vessel tone identified by arterial waveform analysis. Clin Sci (Lond). 2001;100:387–393

PII: S0021-9150(07)00764-2

doi: 10.1016/j.atherosclerosis.2007.11.037

Atherosclerosis
Volume 199, Issue 2 , Pages 362-367 , August 2008