Atherosclerosis
Volume 200, Issue 2 , Pages 417-423 , October 2008

Elevated CRP levels are associated with increased carotid atherosclerosis independent of visceral obesity

  • Reza Alizadeh Dehnavi

      Affiliations

    • Vascular Medicine, Department of General Internal Medicine & Endocrinology, Leiden University Medical Centre, Leiden, The Netherlands
    • Corresponding Author InformationCorresponding author at: Vascular Medicine, Department of General Internal Medicine & Endocrinology, Leiden University Medical Centre, P.O. Box 9600, 2300RC Leiden, The Netherlands. Tel.: +31 71 5262085; fax: +31 71 5248140.
  • ,
  • Albert de Roos

      Affiliations

    • Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands
  • ,
  • Ton J. Rabelink

      Affiliations

    • Department of Nephrology & Einthoven Laboratory, Leiden University Medical Centre, Leiden, The Netherlands
  • ,
  • Johannes van Pelt

      Affiliations

    • Department of Clinical Chemistry, Leiden University Medical Centre, Leiden, The Netherlands
  • ,
  • Maarten J. Wensink

      Affiliations

    • Vascular Medicine, Department of General Internal Medicine & Endocrinology, Leiden University Medical Centre, Leiden, The Netherlands
  • ,
  • Johannes A. Romijn

      Affiliations

    • Vascular Medicine, Department of General Internal Medicine & Endocrinology, Leiden University Medical Centre, Leiden, The Netherlands
  • ,
  • Jouke T. Tamsma

      Affiliations

    • Vascular Medicine, Department of General Internal Medicine & Endocrinology, Leiden University Medical Centre, Leiden, The Netherlands

Received 22 August 2007 ,Revised 18 November 2007 ,Accepted 21 December 2007.

References 

  1. Despres JP, Lemieux I, Prud’homme D. Treatment of obesity: need to focus on high risk abdominally obese patients. BMJ. 2001;322:716–720
  2. Van Gaal LF, Vansant GA, De LI. Upper body adiposity and the risk for atherosclerosis. J Am Coll Nutr. 1989;8:504–514
  3. Wong S, Janssen I, Ross R. Abdominal adipose tissue distribution and metabolic risk. Sports Med. 2003;33:709–726
  4. Pascot A, Lemieux I, Prud’homme D, et al. Reduced HDL particle size as an additional feature of the atherogenic dyslipidemia of abdominal obesity. J Lipid Res. 2001;42:2007–2014
  5. Lemieux I, Pascot A, Prud’homme D, et al. Elevated C-reactive protein: another component of the atherothrombotic profile of abdominal obesity. Arterioscler Thromb Vasc Biol. 2001;21:961–967
  6. Tchernof A, Lamarche B, Prud’homme D, et al. The dense LDL phenotype. Association with plasma lipoprotein levels, visceral obesity, and hyperinsulinemia in men. Diabetes Care. 1996;19:629–637
  7. Reaven GM. The metabolic syndrome: is this diagnosis necessary?. Am J Clin Nutr. 2006;83:1237–1247
  8. Abbasi F, Brown BW, Lamendola C, McLaughlin T, Reaven GM. Relationship between obesity, insulin resistance, and coronary heart disease risk. J Am Coll Cardiol. 2002;40:937–943
  9. Trayhurn P, Wood IS. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr. 2004;92:347–355
  10. Yudkin JS, Stehouwer CD, Emeis JJ, Coppack SW. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue?. Arterioscler Thromb Vasc Biol. 1999;19:972–978
  11. Couillard C, Bergeron N, Prud’homme D, et al. Postprandial triglyceride response in visceral obesity in men. Diabetes. 1998;47:953–960
  12. Ridker PM. Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation. 2003;107:363–369
  13. Yusuf S, Hawken S, Ounpuu S, et al. Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case–control study. Lancet. 2005;366:1640–1649
  14. Hak AE, Stehouwer CD, Bots ML, et al. Associations of C-reactive protein with measures of obesity, insulin resistance, and subclinical atherosclerosis in healthy, middle-aged women. Arterioscler Thromb Vasc Biol. 1999;19:1986–1991
  15. Jarvisalo MJ, Harmoinen A, Hakanen M, et al. Elevated serum C-reactive protein levels and early arterial changes in healthy children. Arterioscler Thromb Vasc Biol. 2002;22:1323–1328
  16. Blackburn R, Giral P, Bruckert E, et al. Elevated C-reactive protein constitutes an independent predictor of advanced carotid plaques in dyslipidemic subjects. Arterioscler Thromb Vasc Biol. 2001;21:1962–1968
  17. Alizadeh Dehnavi R, Doornbos J, Tamsma JT, et al. Assessment of the carotid artery by MRI at 3T: a study on reproducibility. J Magn Reson Imaging. 2007;25:1035–1043
  18. Saam T, Kerwin WS, Chu B, et al. Sample size calculation for clinical trials using magnetic resonance imaging for the quantitative assessment of carotid atherosclerosis. J Cardiovasc Magn Reson. 2005;7:799–808
  19. Fredrikson GN, Hedblad B, Nilsson JA, Alm R, Berglund G, Nilsson J. Association between diet, lifestyle, metabolic cardiovascular risk factors, and plasma C-reactive protein levels. Metabolism. 2004;53:1436–1442
  20. Couillard C, Ruel G, Archer WR, et al. Circulating levels of oxidative stress markers and endothelial adhesion molecules in men with abdominal obesity. J Clin Endocrinol Metab. 2005;90:6454–6459
  21. Pou KM, Massaro JM, Hoffmann U, et al. Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham heart study. Circulation. 2007;116:1234–1241
  22. Timpson NJ, Lawlor DA, Harbord RM, et al. C-reactive protein and its role in metabolic syndrome: mendelian randomisation study. Lancet. 2005;366:1954–1959
  23. Khera A, McGuire DK, Murphy SA, et al. Race and gender differences in C-reactive protein levels. J Am Coll Cardiol. 2005;46:464–469
  24. Shinnar M, Fallon JT, Wehrli S, et al. The diagnostic accuracy of ex vivo MRI for human atherosclerotic plaque characterization. Arterioscler Thromb Vasc Biol. 1999;19:2756–2761
  25. Varghese A, Crowe LA, Mohiaddin RH, et al. Inter-study reproducibility of 3D volume selective fast spin echo sequence for quantifying carotid artery wall volume in asymptomatic subjects. Atherosclerosis. 2005;183:361–366
  26. Cury RC, Houser SL, Furie KL, et al. Vulnerable plaque detection by 3.0 tesla magnetic resonance imaging. Invest Radiol. 2006;41:112–115
  27. Yarnykh VL, Terashima M, Hayes CE, et al. Multicontrast black-blood MRI of carotid arteries: Comparison between 1.5 and 3 tesla magnetic field strengths. J Magn Reson Imaging. 2006;
  28. Despres JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature. 2006;444:881–887
  29. Lemieux I, Drapeau V, Richard D, et al. Waist girth does not predict metabolic complications in severely obese men. Diabetes Care. 2006;29:1417–1419
  30. Koenig W, Lowel H, Baumert J, Meisinger C. C-reactive protein modulates risk prediction based on the Framingham score: implications for future risk assessment: results from a large cohort study in Southern Germany. Circulation. 2004;109:1349–1353

PII: S0021-9150(08)00007-5

doi: 10.1016/j.atherosclerosis.2007.12.050

Atherosclerosis
Volume 200, Issue 2 , Pages 417-423 , October 2008