Atherosclerosis
Volume 204, Issue 1 , Pages 40-46 , May 2009

The oral anti-diabetic agent, gliclazide, inhibits oxidized LDL-mediated LOX-1 expression, metalloproteinase-9 secretion and apoptosis in human aortic endothelial cells

Received 18 March 2008 ,Revised 24 July 2008 ,Accepted 6 August 2008.

References 

  1. Mehta JL, Chen J, Hermonat PL, Romeo F, Novelli G. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1): a critical player in the development of atherosclerosis and related disorders. Cardiovasc Res. 2006;69:36–45
  2. Ishino S, Mukai T, Kume N, et al. Lectin-like oxidized LDL receptor-1 (LOX-1) expression is associated with atherosclerotic plaque instability-analysis in hypercholesterolemic rabbits. Atherosclerosis. 2007;195:48–56
  3. Li D, Mehta JL. Upregulation of endothelial receptor for oxidized LDL (LOX-1) by oxidized LDL and implications in apoptosis of human coronary artery endothelial cells: evidence from use of antisense LOX-1 mRNA and chemical inhibitors. Arterioscler Thromb Vasc Biol. 2000;20:1116–1122
  4. Li D, Liu L, Chen HJ, et al. LOX-1 mediates oxLDL-induced expression of matrix metalloproteinases in human coronary artery endothelial cells. Circulation. 2003;107:612–617
  5. Sawamura T, Kume N, Aoyama T, et al. An endothelial receptor for oxidized low-density lipoprotein. Nature. 1997;386:73–77
  6. Cominacini L, Pasini AF, Garbin U, et al. Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-kappaB through an increased production of intracellular reactive oxygen species. J Biol Chem. 2000;275:12633–12638
  7. Nagase M, Ando K, Nagase T, et al. Redox-sensitive regulation of LOX-1 gene expression in vascular endothelium. Biochem Biophys Res Commun. 2001;281:720–725
  8. Chen M, Nagase M, Fujita T, et al. Diabetes enhances lectin-like oxidized LDL receptor-1 (LOX-1) expression in the vascular endothelium: possible role of LOX-1 ligand and AGE. Biochem Biophys Res Commun. 2001;287:962–968
  9. Li DY, Chen HJ, Mehta JL. Statins inhibit oxidized LDL-mediated LOX-1 expression, uptake of oxidized LDL and reduction in PKB phosphorylation. Cardiovasc Res. 2001;52:130–135
  10. Ouslimani N, Mahrouf M, Peynet J, et al. Metformin reduces endothelial cell expression of both the receptor for advanced glycation end products and lectin-like oxidized receptor 1. Metabolism. 2007;56:308–313
  11. Nomura H, Naito M, Kodama M, Kato Y, Iguchi A. Effects of gliclazide on low-density lipoprotein oxidizability and atherosclerosis in cholesterol-fed rabbits. J Atheroscler Thromb. 2000;7:104–109
  12. Li L, Sawamura T, Renier G. Glucose enhances endothelial LOX-1 expression: role for LOX-1 in glucose-induced human monocyte adhesion to endothelium. Diabetes. 2003;52:1843–1850
  13. Sakurai K, Cominacini L, Garbin U, et al. Induction of endothelin-1 production in endothelial cells via co-operative action between CD40 and lectin-like oxidized LDL receptor (LOX-1). J Cardiovasc Pharmacol. 2004;44:S173–S180
  14. Morawietz H, Duerrschmidt N, Niemann B, et al. Induction of the oxLDL receptor LOX-1 by endothelin-1 in human endothelial cells. Biochem Biophys Res Commun. 2001;284:961–965
  15. Chen J, Mehta JL, Haider N, et al. Role of caspases in oxLDL-induced apoptotic cascade in human coronary artery endothelial cells. Circ Res. 2004;94:370–376
  16. Matsunaga S, Xie Q, Kumano M, et al. Lectin-like oxidized low-density lipoprotein receptor (LOX-1) functions as an oligomer and oligomerization is dependent on receptor density. Exp Cell Res. 2007;313:1203–1214
  17. Derosa G, D’Angelo A, Tinelli C, et al. Evaluation of metalloproteinase 2 and 9 levels and their inhibitors in diabetic and healthy subjects. Diab Metab. 2007;33:129–134
  18. Derosa G, Cicero AF, Scalise F, et al. Metalloproteinase-2 and -9 in diabetic and nondiabetic subjects during acute coronary syndromes. Endothelium. 2007;14:45–51
  19. Kadoglou NP, Daskalopoulou SS, Perrea D, Liapis CD. Matrix metalloproteinases and diabetic vascular complications. Angiology. 2005;56:173–189
  20. Xu XP, Meisel SR, Ong JM, et al. Oxidized low-density lipoprotein regulates matrix metalloproteinase-9 and its tissue inhibitor in human monocyte-derived macrophages. Circulation. 1999;99:993–998
  21. Inoue N, Takeshita S, Gao D, et al. Lysophosphatidylcholine increases the secretion of matrix metalloproteinase 2 through the activation of NADH/NADPH oxidase in cultured aortic endothelial cells. Atherosclerosis. 2001;155:45–52
  22. Felx M, Guyot MC, Isler M, et al. Endothelin-1(ET-1) promotes MMP-2 and MMP-9 induction involving the transcription factor NF-kappaB in human osteosarcoma. Clin Sci. 2006;110:645–654
  23. Nakagawa T, Yasuda T, Hoshikawa H, et al. LOX-1 expressed in cultured rat chondrocytes mediates oxidized LDL-induced cell death-possible role of dephosphorylation of Akt. Biochem Biophys Res Commun. 2002;299:91–97
  24. Li Y, Higashi Y, Itabe H, et al. Insulin-like growth factor-1 receptor activation inhibits oxidized LDL-induced cytochrome C release and apoptosis via the phosphatidylinositol 3 kinase/akt signaling pathway. Arterioscler Thromb Vasc Biol. 2003;23:2178–2184

PII: S0021-9150(08)00552-2

doi: 10.1016/j.atherosclerosis.2008.08.008

Atherosclerosis
Volume 204, Issue 1 , Pages 40-46 , May 2009