Atherosclerosis
Volume 204, Issue 1 , Pages 23-25 , May 2009

Retinol-binding protein-4 is associated with endothelial dysfunction in adults with newly diagnosed type 2 diabetes mellitus

  • Eun Seok Kang

      Affiliations

    • Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea
    • BK21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea
    • ,
  • Chul Woo Ahn

      Affiliations

    • Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea
    • BK21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea
    • ,
  • Hyun Chul Lee

      Affiliations

    • Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea
    • BK21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea
    • ,
  • Bong Soo Cha

      Affiliations

    • Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea
    • BK21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea
    • Corresponding Author InformationCorresponding author at: Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon-Dong, Seodaemoon-Ku, Seoul 120-749, Republic of Korea. Tel.: +82 2 2228 1962; fax: +82 2 393 6884.

Received 14 June 2008

References 

  1. Cines DB, Pollak ES, Buck CA, et al. Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood. 1998;91:3527–3561
  2. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;362:801–809
  3. Behrendt D, Ganz P. Endothelial function. From vascular biology to clinical applications. Am J Cardiol. 2002;90:40L–48L
  4. Kuboki K, Jiang ZY, Takahara N, et al. Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo: a specific vascular action of insulin. Circulation. 2000;101:676–681
  5. Yang Q, Graham TE, Mody N, et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 2005;436:356–362
  6. Muoio DM, Newgard CB. Metabolism: a is for adipokine. Nature. 2005;436:337–338
  7. Graham TE, Yang Q, Bluher M, et al. Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med. 2006;354:2552–2563
  8. Mukherjee D, Yadav JS. Carotid artery intimal-medial thickness: indicator of atherosclerotic burden and response to risk factor modification. Am Heart J. 2002;144:753–759
  9. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419
  10. Corretti MC, Anderson TJ, Benjamin EJ, et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol. 2002;39:257–265
  11. Kang ES, Kim HJ, Kim YM, et al. Serum high sensitivity C-reactive protein is associated with carotid intima-media thickness in type 2 diabetes. Diabetes Res Clin Pract. 2004;66(Suppl 1):S115–S120
  12. Adams DH, Shaw S. Leucocyte-endothelial interactions and regulation of leucocyte migration. Lancet. 1994;343:831–836
  13. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell. 1994;76:301–314
  14. Schmidt AM, Crandall J, Hori O, Cao R, Lakatta E. Elevated plasma levels of vascular cell adhesion molecule-1 (VCAM-1) in diabetic patients with microalbuminuria: a marker of vascular dysfunction and progressive vascular disease. Br J Haematol. 1996;92:747–750
  15. Jager A, van Hinsbergh VW, Kostense PJ, et al. Increased levels of soluble vascular cell adhesion molecule 1 are associated with risk of cardiovascular mortality in type 2 diabetes: the Hoorn study. Diabetes. 2000;49:485–491
  16. Lim SC, Caballero AE, Smakowski P, LoGerfo FW, Horton ES, Veves A. Soluble intercellular adhesion molecule, vascular cell adhesion molecule, and impaired microvascular reactivity are early markers of vasculopathy in type 2 diabetic individuals without microalbuminuria. Diabetes Care. 1999;22:1865–1870
  17. Vincent MA, Barrett EJ, Lindner JR, Clark MG, Rattigan S. Inhibiting NOS blocks microvascular recruitment and blunts muscle glucose uptake in response to insulin. Am J Physiol Endocrinol Metab. 2003;285:E123–E129
  18. Landmesser U, Hornig B, Drexler H. Endothelial function: a critical determinant in atherosclerosis?. Circulation. 2004;109:II27–II33
  19. Takebayashi K, Suetsugu M, Wakabayashi S, Aso Y, Inukai T. Retinol binding protein-4 levels and clinical features of type 2 diabetes patients. J Clin Endocrinol Metab. 2007;92:2712–2719
  20. Bloomgarden ZT. Insulin resistance concepts. Diabetes Care. 2007;30:1320–1326
  21. Ginsberg HN. Diabetic dyslipidemia: basic mechanisms underlying the common hypertriglyceridemia and low HDL cholesterol levels. Diabetes. 1996;45(Suppl 3):S27–S30
  22. Dart AM, Chin-Dusting JP. Lipids and the endothelium. Cardiovasc Res. 1999;43:308–322
  23. Davignon J, Ganz P. Role of endothelial dysfunction in atherosclerosis. Circulation. 2004;109:III27–III32
  24. Schmoelzer I, Wascher TC. Effect of repaglinide on endothelial dysfunction during a glucose tolerance test in subjects with impaired glucose tolerance. Cardiovasc Diabetol. 2006;5:9
  25. Schiffrin EL, Park JB, Intengan HD, Touyz RM. Correction of arterial structure and endothelial dysfunction in human essential hypertension by the angiotensin receptor antagonist losartan. Circulation. 2000;101:1653–1659

PII: S0021-9150(08)00557-1

doi: 10.1016/j.atherosclerosis.2008.08.012

Atherosclerosis
Volume 204, Issue 1 , Pages 23-25 , May 2009

Article Tools

* Image Usage & Resolution