Raloxifene reduces circulating levels of interleukin-7 and monocyte chemoattractant protein-1 in postmenopausal women

Yasui, Toshiyuki; Uemura, Hirokazu; Hyodo, Sari; Yamada, Masayo; Yamamoto, Satoshi; Maegawa, Masahiko; Tsuchiya, Naoko; Noguchi, Masamichi; Yuzurihara, Mitsutoshi; Kase, Yoshio; Irahara, Minoru

doi:10.1016/j.atherosclerosis.2008.09.014

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Volume 204, Issue 2 , Pages 471-475, June 2009

Raloxifene reduces circulating levels of interleukin-7 and monocyte chemoattractant protein-1 in postmenopausal women

Toshiyuki Yasui
- Department of Obstetrics and Gynecology, Course of Human Development, Human Development and Health Science, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, Japan
- Corresponding author. Fax: +81 88 631 2630.
Hirokazu Uemura
- Department of Preventive Medicine, Course of Human Development, Human Development and Health Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
Sari Hyodo
- Course of Medicine, School of Medicine, The University of Tokushima, Japan
Masayo Yamada
- Department of Obstetrics and Gynecology, Course of Human Development, Human Development and Health Science, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, Japan
Satoshi Yamamoto
- Department of Obstetrics and Gynecology, Course of Human Development, Human Development and Health Science, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, Japan
Masahiko Maegawa
- Department of Obstetrics and Gynecology, Course of Human Development, Human Development and Health Science, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, Japan
Naoko Tsuchiya
- Pharmacology Research Department, Tsumura Central Research Institute, Japan
Masamichi Noguchi
- Pharmacology Research Department, Tsumura Central Research Institute, Japan
Mitsutoshi Yuzurihara
- Pharmacology Research Department, Tsumura Central Research Institute, Japan
Yoshio Kase
- Pharmacology Research Department, Tsumura Central Research Institute, Japan
Minoru Irahara
- Department of Obstetrics and Gynecology, Course of Human Development, Human Development and Health Science, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, Japan

Received 7 May 2008; received in revised form 27 August 2008; accepted 6 September 2008. published online 31 October 2008.

Abstract

Objective

The aim of the present study was to determine the effects of raloxifene on changes in circulating levels of cytokines and chemokines in relation to changes in lipid profiles and markers of inflammation in postmenopausal women.

Methods

Fifty-three postmenopausal women aged 45–65 years old were randomly assigned in open, parallel-group fashion to a control group or raloxifene group. Twenty-six women received oral administration of 60mg raloxifene every day and 27 women did not receive any drugs for 12 months. Serum cytokines levels were simultaneously measured using a multiplexed human cytokine assay.

Results

Serum IL-7 concentrations in women who received raloxifene were decreased significantly (p=0.014), and serum monocyte chemoattractant protein (MCP)-1 concentrations in women who received raloxifene were decreased significantly (p=0.0003) at 12 months. In the control group, serum levels of MCP-1 and IL-7 did not show significant changes. There were significant differences (p=0.032 and p=0.0024, respectively) in percentage changes in IL-7 and MCP-1 in the control group and in the raloxifene group. Levels of low-density lipoprotein cholesterol (LDL-C) and E-selectin were decreased significantly in women who received raloxifene, but the percentage changes in LDL-C and E-selectin over a period of 12 months were not significantly correlated with percentage changes in IL-7 and MCP-1 over the same period.