Atherosclerosis
Volume 204, Issue 2 , Pages 497-502 , June 2009

Staccato reperfusion prevents reperfusion injury in patients undergoing coronary angioplasty: A 1-year follow-up pilot study

  • Efstathios K. Iliodromitis

      Affiliations

    • Second Department of Cardiology, Athens University Medical School, Attiko University Hospital, 1 Rimini St, Haidari 12462, Athens, Greece
    • Corresponding Author InformationCorresponding author.
  • ,
  • Ioannis A. Paraskevaidis

      Affiliations

    • Second Department of Cardiology, Athens University Medical School, Attiko University Hospital, 1 Rimini St, Haidari 12462, Athens, Greece
  • ,
  • Katerina Fountoulaki

      Affiliations

    • Second Department of Cardiology, Athens University Medical School, Attiko University Hospital, 1 Rimini St, Haidari 12462, Athens, Greece
  • ,
  • Dimitrios Farmakis

      Affiliations

    • Second Department of Cardiology, Athens University Medical School, Attiko University Hospital, 1 Rimini St, Haidari 12462, Athens, Greece
  • ,
  • Ioanna Andreadou

      Affiliations

    • Department of Pharmaceutical Chemistry, University of Athens School of Pharmacy, Athens, Greece
  • ,
  • Aias Antoniadis

      Affiliations

    • Second Department of Cardiology, Athens University Medical School, Attiko University Hospital, 1 Rimini St, Haidari 12462, Athens, Greece
  • ,
  • Ignatios Ikonomidis

      Affiliations

    • Second Department of Cardiology, Athens University Medical School, Attiko University Hospital, 1 Rimini St, Haidari 12462, Athens, Greece
  • ,
  • Dionyssios Leftheriotis

      Affiliations

    • Second Department of Cardiology, Athens University Medical School, Attiko University Hospital, 1 Rimini St, Haidari 12462, Athens, Greece
  • ,
  • Dimitrios T. Kremastinos

      Affiliations

    • Second Department of Cardiology, Athens University Medical School, Attiko University Hospital, 1 Rimini St, Haidari 12462, Athens, Greece

Received 17 July 2008 ,Revised 25 September 2008 ,Accepted 30 September 2008.

References 

  1. Reimer KA, Jennings RB, Tataum AH. Pathobiology of acute myocardial ischemia: metabolic, functional and ultra structural studies. Am J Cardiol. 1983;52:72A–81A
  2. Van de Werf . Thrombolysis for acute myocardial infarction. Haemostasis. 1994;24:65–68
  3. Nallamothu BK, Bradley EH, Krumholz HM. Time to treatment in primary percutaneous coronary intervention. N Engl J Med. 2007;357:1631–1638
  4. Crisostomo PR, Wairiuko GM, Wang M, Tsai BM, Morrell ED, Meldrum DR. Preconditioning versus postconditioning: mechanisms and therapeutics potentials. J Am Coll Surg. 2006;202:797–812
  5. Yellon DM, Hausenloy DJ. Myocardial reperfusion injury. N Engl J Med. 2007;357:1121–1135
  6. Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 1986;74:1124–1136
  7. Zhao ZQ, Corvera JS, Halkos ME, et al. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Am J Physiol. 2003;285:H579–588
  8. Laskey WK. Brief repetitive balloon occlusions enhance reperfusion during percutaneous coronary intervention for acute myocardial infarction: a pilot study. Catheter Cardiovasc Interv. 2005;65:361–367
  9. Ma X, Zhang X, Li C, Luo M. Effect of postconditioning on coronary blood flow velocity and endothelial function and LV recovery after myocardial infarction. J Interv Cardiol. 2006;19:367–375
  10. Loukogeorgakis SP, Panagiotidou AT, Yellon DM, Danfield JE, Mac Allister RJ. Postconditioning protects against endothelial ischemia-reperfusion injury in the human forearm. Circulation. 2006;113:1015–1019
  11. Staat P, Rioufol G, Piot C, et al. Postconditioning the human heart. Circulation. 2005;112:2143–2148
  12. Thibault H, Piot C, Staat P, et al. Long-term benefit of postconditioning. Circulation. 2008;117:1037–1044
  13. Andreadou I, Iliodromitis EK, Tsovolas K, et al. Acute administration of vitamin E triggers preconditioning via KATP channels and cyclic-GMP without inhibiting lipid peroxidation. Free Radic Biol Med. 2006;41:1092–1099
  14. Piper HM, Garcia-Dorado D, Ovize M. A fresh look at reperfusion injury. Cardiovasc Res. 1998;38:291–300
  15. Andreotti F, Pasceri V, Hackett DR, Davies GJ, Haider AW, Maseri A. Preinfarction angina as a predictor of more rapid coronary thrombolysis in patients with acute myocardial infarction. N Engl J Med. 1996;334:7–12
  16. Jenkins DP, Pugsley WB, Alkhulaifi AM, Kemp M, Hooper J, Yellon DM. Ischemic preconditioning reduces troponin T release in patients undergoing coronary artery bypass surgery. Heart. 1997;77:314–318
  17. Gheeraert PJ, Henriques JP, De Buyzere ML, De Pauw M, Taeymans Y, Zijlstra F. Preinfarction angina protects against out-of-hospital ventricular fibrillation in patients with acute occlusion of the left coronary artery. J Am Coll Cardiol. 2001;38:1369–1376
  18. Iliodromitis EK, Zoga A, Vrettou A, et al. The effectiveness of postconditioning and preconditioning on infarct size in hypercholesterolemic and normal anesthetized rabbits. Atherosclerosis. 2006;188:356–362
  19. Kin H, Zhao Z-Q, Sun H-Y, et al. Postconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting events in the early minutes of reperfusion. Cardiovasc Res. 2004;62:74–85
  20. Yang XM, Philipp S, Downey JM, Cohen MV. Postconditioning's protection is not dependent on circulating blood factors or cells but involves adenosine receptors and requires PI3-kinase and guanylyl cyclase activation. Basic Res Cardiol. 2005;100:57–63
  21. Hearse DJ, Humphrey SM, Chain EB. Abrupt reoxygenation of the anoxic potassium-arrested perfused rat heart: a study of myocardial enzyme release. J Mol Cell Cardiol. 1973;5:395–407
  22. Lemasters JJ, Bond JM, Chacon E, et al. The pH paradox in ischemia–reperfusion injury to cardiac myocytes. EXS. 1996;76:99–114
  23. Parissis JT, Andreadou I, Markantonis SL, et al. Effects of levosimendan on circulating markers of oxidative and nitrosative stress in patients with advanced heart failure. Atherosclerosis. 2007;195:210–215
  24. Halkos ME, Kerendi F, Corvera JS, et al. Myocardial protection with postconditioning is not enhanced by ischemic preconditioning. Ann Thorac Surg. 2004;78:961–969
  25. Wang H, Zhang H, Guo W, et al. Hypoxic postconditioning enhances the survival and inhibits apoptosis of cardiomyocytes following reoxygenation: role of peroxynitrite formation. Apoptosis. 2006;11:1453–1460
  26. Zhao ZQ, Corvera JS, Halkos ME, et al. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Am J Physiol Heart Circ Physiol. 2003;285:H579–588
  27. Liu Y, Yang XM, Iliodromitis EK, et al. Redox signaling at reperfusion is required for protection from ischemic preconditioning but not from a direct PKC activator. Basic Res Cardiol. 2008;103:54–59
  28. Dost T, Cohen MV, Downey JM. Redox signaling triggers protection during the reperfusion rather than the ischemic phase of preconditioning. Basic Res Cardiol. 2008;103:378–384
  29. Zweire JL, Wang P, Kuppusamy P. Direct measurement of nitric oxide generation in the ischemic heart using electron paramagnetic resonance spectroscopy. J Biol Chem. 1995;270:304–307
  30. Kloner RA, Bolli R, Marban E, Reinlib L, Branwald E and participants. Medical and cellular implications of stunning, hibernation and preconditioning. An NHLBI Workshop. Circulation 1998;97:1848–67.
  31. Paraskevaidis IA, Iliodromitis EK, Vlahakos D, et al. Deferoxamine infusion during coronary artery bypass grafting ameliorates lipid peroxidation and protects the myocardium against reperfusion injury: immediate and long-term significance. Eur Heart J. 2005;26:263–270
  32. Hausenloy DJ, Yellon DM. Preconditioning and postconditioning: new strategies for cardioprotection. Diabetes Obes Metab. 2008;10:451–459
  33. Kyriakides ZS, Psychari S, Iliodromitis EK, Kolettis TM, Sbarouni E, Kremastinos DT. Hyperlipidemia prevents the expected reduction of myocardial ischemia on repeated balloon inflations during angioplasty. Chest. 2002;121:1211–1215
  34. Matsuo H, Watanabe S, Segawa T, et al. Evidence of pharmacologic preconditioning during PTCA by intravenous pretreatment with ATP-sensitive K+ channel opener nicorandil. Eur Heart J. 2003;24:1296–1303
  35. Leesar MA, Stoddard MF, Xuan YT, Tang XL, Bolli R. Nonelectrocardiographic evidence that both ischemic preconditioning and adenosine preconditioning exist in humans. J Am Coll Cardiol. 2003;42:437–445
  36. Matsubara T, Minatoguchi S, Matsuo H, et al. Three minute, but not one minute, ischemia and nicorandil have a preconditioning effect in patients with coronary artery disease. J Am Coll Cardiol. 2000;35:345–351

PII: S0021-9150(08)00696-5

doi: 10.1016/j.atherosclerosis.2008.09.037

Atherosclerosis
Volume 204, Issue 2 , Pages 497-502 , June 2009