Atherosclerosis
Volume 204, Issue 2 , Pages 590-594 , June 2009

Plasma des-acyl ghrelin, but not plasma HMW adiponectin, is a useful cardiometabolic marker for predicting atherosclerosis in elderly hypertensive patients

  • Yuichiro Yano

      Affiliations

    • Division of Internal Medicine, Nango National Health Insurance Hospital, Japan
    • Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Japan
    • Corresponding Author InformationCorresponding author at: Division of Internal Medicine, Nango National Health Insurance Hospital, 1078 Mikado, Nango, Misato Town, Miyazaki 883-0306, Japan. Tel.: +81 982 59 0017; fax: +81 982 59 0213.
    • ,
  • Koji Toshinai

      Affiliations

    • Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Japan
    • ,
  • Takashi Inokuchi

      Affiliations

    • Department of Orthopedic Surgery, Kitaura National Health Insurance Hospital, Japan
    • ,
  • Kenji Kangawa

      Affiliations

    • Department of Biochemistry, National Cardiovascular Center Research Institute, Japan
    • ,
  • Kazuyuki Shimada

      Affiliations

    • Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Japan
    • ,
  • Kazuomi Kario

      Affiliations

    • Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Japan
    • ,
  • Masamitsu Nakazato

      Affiliations

    • Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Japan

Received 9 August 2008 ,Revised 17 September 2008 ,Accepted 12 October 2008.

References 

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  2. Trujillo ME, Scherer PE. Adipose tissue-derived factors: impact on health and disease. Endocrinol Rev. 2006;27:762–778
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  4. Pischon T, Girman CJ, Hotamisligil GS, Rifai N, Hu FB, Rimm EB. Plasma adiponectin levels and risk of myocardial infarction in men. JAMA. 2004;291:1730–1737
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  9. Pajvani UB, Du X, Combs TP, et al. Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity. J Biol Chem. 2003;278:9073–9085
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  12. Kleinz MJ, Maguire JJ, Skepper JN, Davenport AP. Functional and immunocytochemical evidence for a role of ghrelin and des-octanoyl ghrelin in the regulation of vascular tone in man. Cardiovasc Res. 2006;69:227–235
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  15. Akamizu T, Shinomiya T, Irako T, et al. Separate measurement of plasma levels of acylated and desacyl ghrelin in healthy subjects using a new direct ELISA assay. J Clin Endocrinol Metab. 2005;90:6–9
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  17. The committee to evaluate diagnostic standards for metabolic syndrome 2005 Definition and the diagnostic standard for metabolic syndrome. Nippon Naika Gakkai Zasshi. 2005;94:794–809[in Japanese]
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PII: S0021-9150(08)00747-8

doi: 10.1016/j.atherosclerosis.2008.10.013

Atherosclerosis
Volume 204, Issue 2 , Pages 590-594 , June 2009

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