Atherosclerosis
Volume 204, Issue 2 , Pages 612-618 , June 2009

Echogenecity of the carotid intima–media complex is related to cardiovascular risk factors, dyslipidemia, oxidative stress and inflammation: The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study

  • Jessika Andersson

      Affiliations

    • Department of Medicine, Uppsala University Hospital, 751 85 Uppsala, Sweden
    • Corresponding Author InformationCorresponding author. Tel.: +46 186110000.
    • ,
  • Johan Sundström

      Affiliations

    • Department of Medicine, Uppsala University Hospital, 751 85 Uppsala, Sweden
    • ,
  • Thomas Gustavsson

      Affiliations

    • Department of Signals and Systems, Chalmers University of Technology, Sweden
    • ,
  • Johannes Hulthe

      Affiliations

    • Wallenberg Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden
    • AstraZeneca R&D Mölndal, Sweden
    • ,
  • Anders Elmgren

      Affiliations

    • AstraZeneca R&D Mölndal, Sweden
    • ,
  • Kersti Zilmer

      Affiliations

    • Department of Biochemistry, University of Tartu, Estonia
    • ,
  • Mihkel Zilmer

      Affiliations

    • Department of Biochemistry, University of Tartu, Estonia
    • ,
  • Lars Lind

      Affiliations

    • Department of Medicine, Uppsala University Hospital, 751 85 Uppsala, Sweden

Received 4 July 2008 ,Revised 5 October 2008 ,Accepted 21 October 2008.

References 

  1. Bots ML, Hoes AW, Koudstaal PJ, Hofman A, Grobbee DE. Common carotid intima-media thickness and risk of stroke and myocardial infarction: the rotterdam study. Circulation. 1997;96:1432–1437
  2. O’Leary DH, Polak JF, Kronmal RA, et al. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular health study collaborative research group. N Engl J Med. 1999;340:14–22
  3. Heiss G, Sharrett AR, Barnes R, et al. Carotid atherosclerosis measured by b-mode ultrasound in populations: associations with cardiovascular risk factors in the aric study. Am J Epidemiol. 1991;134:250–256
  4. Polak JF, Shemanski L, O’Leary DH, et al. Hypoechoic plaque at us of the carotid artery: an independent risk factor for incident stroke in adults aged 65 years or older. Cardiovascular health study. Radiology. 1998;208:649–654
  5. Honda O, Sugiyama S, Kugiyama K, et al. Echolucent carotid plaques predict future coronary events in patients with coronary artery disease. J Am Coll Cardiol. 2004;43:1177–1184
  6. Ross R. Atherosclerosis—an inflammatory disease. N Engl J Med. 1999;340:115–126
  7. Winbeck K, Kukla C, Poppert H, et al. Elevated c-reactive protein is associated with an increased intima to media thickness of the common carotid artery. Cerebrovasc Dis. 2002;13:57–63
  8. Lorenz MW, Karbstein P, Markus HS, Sitzer M. High-sensitivity c-reactive protein is not associated with carotid intima-media progression: the carotid atherosclerosis progression study. Stroke. 2007;38:1774–1779
  9. Lind L, Andersson J, Ronn M, Gustavsson T. The echogenecity of the intima–media complex in the common carotid artery is closely related to the echogenecity in plaques. Atherosclerosis. 2007;
  10. Lind L, Andersson J, Ronn M, et al. Brachial artery intima–media thickness and echogenicity in relation to lipids and markers of oxidative stress in elderly subjects:-the prospective investigation of the vasculature in uppsala seniors (pivus) study. Lipids. 2007;
  11. Lind L, Fors N, Hall J, Marttala K, Stenborg A. A comparison of three different methods to determine arterial compliance in the elderly: the prospective investigation of the vasculature in uppsala seniors (pivus) study. J Hypertens. 2006;24:1075–1082
  12. Wilson PW, D’Agostino RB, Levy D, et al. Prediction of coronary heart disease using risk factor categories. Circulation. 1998;97:1837–1847
  13. Liang Q, Wendelhag I, Wikstrand J, Gustavsson T. A multiscale dynamic programming procedure for boundary detection in ultrasonic artery images. IEEE Trans Med Imaging. 2000;19:127–142
  14. Yu CM, Zhang Q, Lam L, et al. Comparison of intensive and low-dose atorvastatin therapy in the reduction of carotid intimal-medial thickness in patients with coronary heart disease. Heart. 2007;93:933–939
  15. Watanabe K, Sugiyama S, Kugiyama K, et al. Stabilization of carotid atheroma assessed by quantitative ultrasound analysis in nonhypercholesterolemic patients with coronary artery disease. J Am Coll Cardiol. 2005;46:2022–2030
  16. Ahotupa M, Asankari TJ. Baseline diene conjugation in LDL lipids: an indicator of circulating oxidized LDL. Free Radic Biol Med. 1999;27:1141–1150
  17. Annuk M, Fellstrom B, Akerblom O, et al. Oxidative stress markers in pre-uremic patients. Clin Nephrol. 2001;56:308–314
  18. El-Barghouty NM, Levine T, Ladva S, Flanagan A, Nicolaides A. Histological verification of computerised carotid plaque characterisation. Eur J Vasc Endovasc Surg. 1996;11:414–416
  19. Chambless LE, Folsom AR, Davis V, et al. Risk factors for progression of common carotid atherosclerosis: the atherosclerosis risk in communities study, 1987–1998. Am J Epidemiol. 2002;155:38–47
  20. O’Leary DH, Polak JF, Kronmal RA, et al. Distribution and correlates of sonographically detected carotid artery disease in the cardiovascular health study. The chs collaborative research group. Stroke. 1992;23:1752–1760
  21. Walldius G, Jungner I, Holme I, et al. High apolipoprotein b, low apolipoprotein a–i, and improvement in the prediction of fatal myocardial infarction (amoris study): a prospective study. Lancet. 2001;358:2026–2033
  22. Mathiesen EB, Bonaa KH, Joakimsen O. Low levels of high-density lipoprotein cholesterol are associated with echolucent carotid artery plaques: the tromso study. Stroke. 2001;32:1960–1965
  23. Wallenfeldt K, Fagerberg B, Wikstrand J, Hulthe J. Oxidized low-density lipoprotein in plasma is a prognostic marker of subclinical atherosclerosis development in clinically healthy men. J Intern Med. 2004;256:413–420
  24. Kampus P, Kals J, Ristimae T, et al. Augmentation index and carotid intima–media thickness are differently related to age, c-reactive protein and oxidized low-density lipoprotein. J Hypertens. 2007;25:819–825
  25. Karelson E, Mahlapuu R, Zilmer M, et al. Possible signaling by glutathione and its novel analogue through potent stimulation of fontocortical g proteins in normal aging and in alzheimer's disease. Ann N Y Acad Sci. 2002;973:537–540
  26. Zilmer US M, Rehema A, Langel Ü. Drug Des Rev—Online. 2005;2:121–127
  27. Ridker PM, Rifai N, Rose L, Buring JE, Cook NR. Comparison of c-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med. 2002;347:1557–1565
  28. Cao JJ, Arnold AM, Manolio TA, et al. Association of carotid artery intima–media thickness, plaques, and c-reactive protein with future cardiovascular disease and all-cause mortality: the cardiovascular health study. Circulation. 2007;116:32–38
  29. Mathiesen EB, Joakimsen O, Bonaa KH. Prevalence of and risk factors associated with carotid artery stenosis: the tromso study. Cerebrovasc Dis. 2001;12:44–51
  30. Makita S, Nakamura M, Hiramori K. The association of c-reactive protein levels with carotid intima–media complex thickness and plaque formation in the general population. Stroke. 2005;36:2138–2142
  31. Sander D, Schulze-Horn C, Bickel H, et al. Combined effects of hemoglobin a1c and c-reactive protein on the progression of subclinical carotid atherosclerosis: the invade study. Stroke. 2006;37:351–357
  32. Porta B, Baldassarre D, Camera M, et al. E-selectin and tfpi are associated with carotid intima–media thickness in stable ihd patients: the baseline findings of the miami study. Nutr Metab Cardiovasc Dis. 2007;
  33. Temelkova-Kurktschiev T, Koehler C, Henkel E, Hanefeld M. Leukocyte count and fibrinogen are associated with carotid and femoral intima–media thickness in a risk population for diabetes. Cardiovasc Res. 2002;56:277–283
  34. Hwang SJ, Ballantyne CM, Sharrett AR, et al. Circulating adhesion molecules vcam-1, icam-1, and e-selectin in carotid atherosclerosis and incident coronary heart disease cases: the atherosclerosis risk in communities (aric) study. Circulation. 1997;96:4219–4225

PII: S0021-9150(08)00759-4

doi: 10.1016/j.atherosclerosis.2008.10.038

Atherosclerosis
Volume 204, Issue 2 , Pages 612-618 , June 2009

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