Atherosclerosis
Volume 205, Issue 1 , Pages 239-243 , July 2009

Myeloperoxidase overexpression in children with hypercholesterolemia

  • P. Pignatelli

      Affiliations

    • Division of Internal Medicine H, “La Sapienza” University of Rome, Italy
    • Department of Experimental Medicine, “La Sapienza” University of Rome, Italy
    • Corresponding Author InformationCorresponding author at: Division of Internal Medicine H, Viale del Policlinico 155, Roma 00161, Italy. Tel.: +39 064997777; fax: +390649970102.
    • ,
  • L. Loffredo

      Affiliations

    • Division of Internal Medicine H, “La Sapienza” University of Rome, Italy
    • Department of Experimental Medicine, “La Sapienza” University of Rome, Italy
    • ,
  • F. Martino

      Affiliations

    • Center of Clinic Lipid Research, Department of Pediatrics, “La Sapienza” University of Rome, Italy
    • ,
  • E. Catasca

      Affiliations

    • Center of Clinic Lipid Research, Department of Pediatrics, “La Sapienza” University of Rome, Italy
    • ,
  • R. Carnevale

      Affiliations

    • Division of Internal Medicine H, “La Sapienza” University of Rome, Italy
    • Department of Experimental Medicine, “La Sapienza” University of Rome, Italy
    • ,
  • C. Zanoni

      Affiliations

    • Division of Internal Medicine H, “La Sapienza” University of Rome, Italy
    • Department of Experimental Medicine, “La Sapienza” University of Rome, Italy
    • ,
  • M. Del Ben

      Affiliations

    • Division of Internal Medicine H, “La Sapienza” University of Rome, Italy
    • Department of Experimental Medicine, “La Sapienza” University of Rome, Italy
    • ,
  • R. Antonini

      Affiliations

    • Division of Internal Medicine H, “La Sapienza” University of Rome, Italy
    • Department of Clinical and Medical Therapy, “La Sapienza” University of Rome, Italy
    • ,
  • S. Basili

      Affiliations

    • Division of Internal Medicine H, “La Sapienza” University of Rome, Italy
    • Department of Clinical and Medical Therapy, “La Sapienza” University of Rome, Italy
    • ,
  • F. Violi

      Affiliations

    • Division of Internal Medicine H, “La Sapienza” University of Rome, Italy
    • Department of Experimental Medicine, “La Sapienza” University of Rome, Italy

Received 19 August 2008 ,Revised 21 October 2008 ,Accepted 27 October 2008.

References 

  1. Napoli C, Glass CK, Witztum JL, Deutsch R, D’Armiento FP, Palinski W. Influence of maternal hypercholesterolaemia during pregnancy on progression of early atherosclerotic lesions in childhood: Fate of Early Lesions in Children (FELIC) study. Lancet. 1999;354:1234–1241
  2. Newman WP, Freedman DS, Voors AW, et al. Relation of serum lipoprotein levels and systolic blood pressure to early atherosclerosis, The Bogalusa Heart Study. N Engl J Med. 1986;314:138–144
  3. McGill HC, McMahan CA, Malcom GT, Oalmann MC, Strong JP. Effects of serum lipoproteins and smoking on atherosclerosis in young men and women, The PDAY Research Group. Pathobiological Determinants of Atherosclerosis in Youth. Arterioscler Thromb Vasc Biol. 1997;17:95–106
  4. Raitakari OT, Juonala M, Kähönen M, et al. Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study. JAMA. 2003;290:2277–2283
  5. Tsimikas S. Oxidative biomarkers in the diagnosis and prognosis of cardiovascular disease. Am J Cardiol. 2006;98:9P–17P
  6. Martino F, Loffredo L, Carnevale R, et al. Oxidative stress is associated with arterial dysfunction and enhanced intima-media thickness in children with hypercholesterolemia potential role of NADPH oxidase. Pediatrics. 2008;122:e648–e655
  7. Tsukahara H. Biomarkers for oxidative stress: clinical application in pediatric medicine. Curr Med Chem. 2007;14:339–351
  8. Kauffman LD, Sokol RJ, Jones RH, Awad JA, Rewers MJ, Norris JM. Urinary F2-isoprostanes in young healthy children at risk for type 1 diabetes mellitus. Free Radic Biol Med. 2003;35:551–557
  9. Podrez EA, Abu-Soud HM, Hazen SL. Myeloperoxidase-generated oxidants and atherosclerosis. Free Radic Biol Med. 2000;28:1717–1725
  10. Campagna F, Martino F, Bifolco M, et al. Detection of familial hypercholesterolemia in a cohort of children with hypercholesterolemia: results of a family and DNA-based screening. Atherosclerosis. 2008;196:356–364
  11. Tanner JM. Growth at adolescence. The development of the reproductive system. 2nd ed.. Oxford, United Kingdom: Blackwell; 1962;pp. 28–39
  12. Martino F, Pignatelli P, Martino E, et al. Early increase of oxidative stress and soluble CD40L in children with hypercholesterolemia. J Am Coll Cardiol. 2007;49:1974–1981
  13. Van den Bruel A, Bartholomeeusen S, Aertgeerts B, Truyers C, Buntinx F. Serious infections in children: an incidence study in family practice. BMC Fam Pract. 2006;7:23
  14. Weinsier RL, Schutz Y, Bracco D. Reexamination of the relationship of resting metabolic rate to fat-free mass and to the metabolically active components of fat-free mass in humans. Am J Clin Nutr. 1992;55:790–794
  15. Podrez EA, Febbraio M, Sheibani N, et al. Macrophage scavenger receptor CD36 is the major receptor for LDL modified monocyte-generated reactive nitrogen species. J Clin Invest. 2000;105:1095–1108
  16. Fu X, Kassim SY, Parks WC, Heinecke JW. Hypochlorous acid oxygenates the cysteine switch domain of pro-matrilysin (MMP-7): a mechanism for matrix metalloproteinase activation and atherosclerotic plaque rupture bymyeloperoxidase. J Biol Chem. 2001;276:41279–41287
  17. Abu-Soud HM, Hazen SL. Nitric oxide is a physiological substrate for mammalian peroxidases. J Biol Chem. 2000;275:37524–37532
  18. Eiserich JP, Baldus S, Brennan ML, et al. Myeloperoxidase, a leukocyte-derived vascular NO oxidase. Science. 2002;296:2391–2394
  19. Zhang R, Brennan ML, Fu X, Aviles RJ, Pearce GL, Penn MS, et al. Association between myeloperoxidase levels and risk of coronary artery disease. JAMA. 2001;286:2136–2142
  20. Brennan ML, Penn MS, Van Lente F, et al. Prognostic value of myeloperoxidase in patients with chest pain. N Engl J Med. 2003;349:1595–1604
  21. Baldus S, Heeschen C, Meinertz T, et al. CAPTURE Investigators. Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes. Circulation. 2003;108:1440–1445
  22. Pignatelli P, Sanguigni V, Lenti L, et al. Oxidative stress-mediated platelet CD40 ligand upregulation in patients with hypercholesterolemia: effect of atorvastatin. J Thromb Haemost. 2007;5:1170–1178
  23. Hoy A, Trégouët D, Leininger-Muller B, et al. Serum myeloperoxidase concentration in a healthy population: biological variations, familial resemblance and new genetic polymorphisms. Eur J Hum Genet. 2001;9:780–786

☆ This study was supported in part by a grant from the “La Sapienza” University of Rome (Ateneo 2006) to FV.

PII: S0021-9150(08)00764-8

doi: 10.1016/j.atherosclerosis.2008.10.025

Atherosclerosis
Volume 205, Issue 1 , Pages 239-243 , July 2009

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