Atherosclerosis
Volume 205, Issue 1 , Pages 251-254 , July 2009

Addition of 2.5g l-arginine in a fatty meal prevents the lipemia-induced endothelial dysfunction in healthy volunteers

  • Katrin Borucki

      Affiliations

    • Institute of Clinical Chemistry, Magdeburg University Hospital, Leipziger Str. 44, D-39120 Magdeburg, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 391 6713901; fax: +49 391 6713902.
    • ,
  • Steffi Aronica

      Affiliations

    • Institute of Clinical Chemistry, Magdeburg University Hospital, Leipziger Str. 44, D-39120 Magdeburg, Germany
    • ,
  • Irmgard Starke

      Affiliations

    • Department of Paediatrics, University of Magdeburg, Germany
    • ,
  • Claus Luley

      Affiliations

    • Institute of Clinical Chemistry, Magdeburg University Hospital, Leipziger Str. 44, D-39120 Magdeburg, Germany
    • ,
  • Sabine Westphal

      Affiliations

    • Institute of Clinical Chemistry, Magdeburg University Hospital, Leipziger Str. 44, D-39120 Magdeburg, Germany

Received 7 July 2008 ,Revised 17 October 2008 ,Accepted 27 October 2008.

References 

  1. Vogel RA. Coronary risk factor, endothelial function, an atherosclerosis: a review. Clin Cardiol. 1997;20:426–432
  2. Vogel RA, Coretti MC, Plotnick GD. Effect of a single high-fat meal on endothelial function in healthy subjects. Am J Cardiol. 1997;79:350–354
  3. Ceriello A, Taboga C, Tonutti L, et al. Evidence for an independent and cumulative effect of postprandial hypertriglyceridemia and hyperglycemia on endothelial dysfunction and oxidative stress generation: effects of short- and long-term simvastatin treatment. Circulation. 2002;106:1211–1218
  4. Gaenzer H, Sturm W, Neumayr G, et al. Pronounced postprandial lipemia impairs endothelium-dependent dilation of the brachial artery in men. Cardiovasc Res. 2001;52:509–516
  5. Lundmann P, Eriksson M, Schenck-Gustafsson K, Karpe F, Tornvall P. Transient triglyceridemia decreases vascular reactivity in young, healthy men without risk factors for coronary heart disease. Circulation. 1997;96:3266–3268
  6. Westphal S, Kästner S, Taneva E, Leodolter , Dierkes J, Luley C. Postprandial lipid and carbohydrates responses after ingestion of a casein enriched mixed meal. Am J Clin Nutr. 2004;80:284–290
  7. Westphal S, Taneva E, Kästner S, et al. Endothelial dysfunction induced by postprandial lipemia is neutralized by addition of proteins to the fatty meal. Atherosclerosis. 2006;185:313–319
  8. Böger RH. The pharmacodynamics of l-arginine. J Nutr. 2007;137:1650S–1655S[Review]
  9. Kuboki K, Jiang ZY, Takahara N, et al. Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo: a specific vascular action of insulin. Circulation. 2000;101:676–681
  10. Zeng G, Nystrom FH, Ravichandran LV, et al. Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells. Circulation. 2000;101:1539–1545
  11. Trovati M, Massucco P, Mattiello L, et al. The insulin-induced increase of guanosine-3′,5′-cyclic monophosphate in human platelets is mediated by nitric oxide. Diabetes. 1996;45:768–770
  12. Plotnick GD, Corretti MC, Vogel RA. Effect of antioxidant vitamins on the transient impairment of endothelium-dependent brachial artery vasoactivity following a single high-fat meal. JAMA. 1997;278:1682–1686
  13. Lin CC, Tsai WC, Chen JY, Li YH, Lin LJ, Chen JH. Supplements of l-arginine attenuate the effects of high-fat meal on endothelial function and oxidative stress. Int J Cardiol 2007 (July) [Epub ahead of print].
  14. Souci SW, Fachmann W, Kraut H. Food composition and nutrition tables. 6th revised and completed edition. London: Medpharm Scientific Publishers; 2000;
  15. Zeng G, Quon MJ. Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells. J Clin Invest. 1996;98:894–898
  16. Chin-Dusting JPF, Alexander CT, Arnold PJ, Hodgson WC, Lus AS, Jennings GLR. Effects of in vivo and in vitro l-arginine supplementation on healthy human vessels. J Cardiovasc Pharmacol. 1996;28:158–166
  17. Adams MR, Forsyth CJ, Jessup W, Robinson J, Celermajer DS. Oral l-arginine inhibits platelet aggregation but does not enhance endothelium-dependent dilation in healthy young men. J Am Coll Cardiol. 1995;26:1054–1061
  18. Blum A, Hathaway L, Mincemoyer R, et al. Effects of oral l-arginine on endothelium-dependent vasodilation and markers of inflammation in healthy postmenopausal women. J Am Coll Cardiol. 2000;35:271–276
  19. Mariotti F, Huneau JF, Szezepanski I, et al. Meal amino acids with varied levels of arginine do not affect postprandial vascular endothelial function in healthy young men. J Nutr. 2007;137:1383–1389
  20. Taneva E, Borucki K, Wiens L, et al. Early effects on endothelial function of atorvastatin 40mg twice daily and its withdrawal. Am J Cardiol. 2006;97:1002–1006
  21. Witte DR, Westerink J, de Koning EJ, van der Graaf Y, Grobbee DE, Bots ML. Is the association between flow-mediated dilation and cardiovascular risk limited to low-risk populations?. J Am Coll Cardiol. 2005;45:1987–1993

PII: S0021-9150(08)00766-1

doi: 10.1016/j.atherosclerosis.2008.10.026

Atherosclerosis
Volume 205, Issue 1 , Pages 251-254 , July 2009

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