Atherosclerosis
Volume 204, Issue 2 , Pages 624-635 , June 2009

Alcohol consumption and the prevalence of metabolic syndrome: A meta-analysis of observational studies

  • Alkerwi Ala’a

      Affiliations

    • Centre de Recherche Public Santé, Centre d’Etudes en Santé, Grand-Duchy of Luxembourg, 1A rue Thomas Edison, L-1445 Strassen, Luxembourg
    • Corresponding Author InformationCorresponding author. Tel.: +352 26 970 743; fax: +352 26 970 719.
  • ,
  • Boutsen Michel

      Affiliations

    • Département de Biostatistique, Ecole de Santé Publique, Université Libre de Bruxelles, Belgium
  • ,
  • Vaillant Michel

      Affiliations

    • Centre de Recherche Public Santé, Centre d’Etudes en Santé, Grand-Duchy of Luxembourg, 1A rue Thomas Edison, L-1445 Strassen, Luxembourg
  • ,
  • Barre Jessica

      Affiliations

    • Centre de Recherche Public Santé, Centre d’Etudes en Santé, Grand-Duchy of Luxembourg, 1A rue Thomas Edison, L-1445 Strassen, Luxembourg
  • ,
  • Lair Marie-Lise

      Affiliations

    • Centre de Recherche Public Santé, Centre d’Etudes en Santé, Grand-Duchy of Luxembourg, 1A rue Thomas Edison, L-1445 Strassen, Luxembourg
  • ,
  • Albert Adelin

      Affiliations

    • Ecole de Santé Publique, Université de Liège, Belgium
  • ,
  • Guillaume Michèle

      Affiliations

    • Ecole de Santé Publique, Université de Liège, Belgium
  • ,
  • Dramaix Michèle

      Affiliations

    • Département de Biostatistique, Ecole de Santé Publique, Université Libre de Bruxelles, Belgium

Received 30 May 2008 ,Revised 16 September 2008 ,Accepted 29 October 2008.

References 

  1. Gami AS, Witt BJ, Howard DE, et al. Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies. J Am Coll Cardiol. 2007;49(4):403–414
  2. Galassi A, Reynolds K, He J. Metabolic syndrome and risk of cardiovascular disease: a meta-analysis. Am J Med. 2006;119(10):812–819
  3. Girman CJ, Rhodes T, Mercuri M, et al. The metabolic syndrome and risk of major coronary events in the Scandinavian Simvastatin Survival Study (4S) and the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS). Am J Cardiol. 2004;93(2):136–141
  4. Lakka HM, Laaksonen DE, Lakka TA, et al. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA. 2002;288(21):2709–2716
  5. Stern MP, Williams K, Gonzalez-Villalpando C, Hunt KJ, Haffner SM. Does the metabolic syndrome improve identification of individuals at risk of type 2 diabetes and/or cardiovascular disease?. Diabetes Care. 2004;27(11):2676–2681
  6. Malik S, Wong ND, Franklin SS, et al. Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults. Circulation. 2004;110(10):1245–1250
  7. Isomaa B, Almgren P, Tuomi T, et al. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care. 2001;24(4):683–689
  8. Lorenzo C, Williams K, Hunt KJ, Haffner SM. The National Cholesterol Education Program - Adult Treatment Panel III, International Diabetes Federation, and World Health Organization definitions of the metabolic syndrome as predictors of incident cardiovascular disease and diabetes. Diabetes Care. 2007;30(1):8–13
  9. Bonora E. The metabolic syndrome and cardiovascular disease. Ann Med. 2006;38(1):64–80
  10. Wilson PW, D’Agostino RB, Parise H, Sullivan L, Meigs JB. Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus. Circulation. 2005;112(20):3066–3072
  11. Lau DC, Yan H, Dhillon B. Metabolic syndrome: a marker of patients at high cardiovascular risk. Can J Cardiol. 2006;22(Suppl B):85B–90B
  12. He Y, Jiang B, Wang J, et al. Prevalence of the metabolic syndrome and its relation to cardiovascular disease in an elderly Chinese population. J Am Coll Cardiol. 2006;47(8):1588–1594
  13. Ford ES, Kohl HW, Mokdad AH, Ajani UA. Sedentary behavior, physical activity, and the metabolic syndrome among U.S. adults. Obes Res. 2005;13(3):608–614
  14. Liese AD, Mayer-Davis EJ, Haffner SM. Development of the multiple metabolic syndrome: an epidemiologic perspective. Epidemiol Rev. 1998;20(2):157–172
  15. Sookoian SC, Gonzalez C, Pirola CJ. Meta-analysis on the G-308A tumor necrosis factor alpha gene variant and phenotypes associated with the metabolic syndrome. Obes Res. 2005;13(12):2122–2131
  16. Xin X, He J, Frontini MG, Ogden LG, Motsamai OI, Whelton PK. Effects of alcohol reduction on blood pressure: a meta-analysis of randomized controlled trials. Hypertension. 2001;38(5):1112–1117
  17. Nakanishi N, Makino K, Nishina K, Suzuki K, Tatara K. Relationship of light to moderate alcohol consumption and risk of hypertension in Japanese male office workers. Alcohol Clin Exp Res. 2002;26(7):988–994
  18. Koppes LL, Dekker JM, Hendriks HF, Bouter LM, Heine RJ. Moderate alcohol consumption lowers the risk of type 2 diabetes: a meta-analysis of prospective observational studies. Diabetes Care. 2005;28(3):719–725
  19. Bell RA, Mayer-Davis EJ, Martin MA, D’Agostino RB, Haffner SM. Associations between alcohol consumption and insulin sensitivity and cardiovascular disease risk factors: the Insulin Resistance and Atherosclerosis Study. Diabetes Care. 2000;23(11):1630–1636
  20. Goude D, Fagerberg B, Hulthe J. Alcohol consumption, the metabolic syndrome and insulin resistance in 58-year-old clinically healthy men (AIR study). Clin Sci (Lond). 2002;102(3):345–352
  21. Kiechl S, Willeit J, Poewe W, et al. Insulin sensitivity and regular alcohol consumption: large, prospective, cross sectional population study (Bruneck study). BMJ. 1996;313(7064):1040–1044
  22. Magis DC JB, Scheen AJ. Alcohol, Sensibilité à l’insuline et diabète sucré. Rev Med Lieg. 2003;58:501–507
  23. Hulley SB, Gordon S. Alcohol and high-density lipoprotein cholesterol: causal inference from diverse study designs. Circulation. 1981;64(3 Pt 2):57–63
  24. van Tol A, van der Gaag MS, Scheek LM, van Gent T, Hendriks HF. Changes in postprandial lipoproteins of low and high density caused by moderate alcohol consumption with dinner. Atherosclerosis. 1998;141(Suppl 1):S101–S103
  25. Kato I, Kiyohara Y, Kubo M, et al. Insulin-mediated effects of alcohol intake on serum lipid levels in a general population: the Hisayama Study. J Clin Epidemiol. 2003;56(2):196–204
  26. Yoon YS, Oh SW, Baik HW, Park HS, Kim WY. Alcohol consumption and the metabolic syndrome in Korean adults: the 1998 Korean National Health and Nutrition Examination Survey. Am J Clin Nutr. 2004;80(1):217–224
  27. Nanchahal K, Ashton WD, Wood DA. Alcohol consumption, metabolic cardiovascular risk factors and hypertension in women. Int J Epidemiol. 2000;29(1):57–64
  28. Wannamethee SG, Shaper AG. Alcohol, body weight, and weight gain in middle-aged men. Am J Clin Nutr. 2003;77(5):1312–1317
  29. Ajani UA, Gaziano JM, Lotufo PA, et al. Alcohol consumption and risk of coronary heart disease by diabetes status. Circulation. 2000;102(5):500–505
  30. Rimm EB, Williams P, Fosher K, Criqui M, Stampfer MJ. Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors. BMJ. 1999;319(7224):1523–1528
  31. Reynolds K, Lewis B, Nolen JD, Kinney GL, Sathya B, He J. Alcohol consumption and risk of stroke: a meta-analysis. JAMA. 2003;289(5):579–588
  32. Berger K, Ajani UA, Kase CS, et al. Light-to-moderate alcohol consumption and risk of stroke among U.S. male physicians. N Engl J Med. 1999;341(21):1557–1564
  33. Kiechl S, Willeit J, Rungger G, Egger G, Oberhollenzer F, Bonora E. Alcohol consumption and atherosclerosis: what is the relation? Prospective results from the Bruneck Study. Stroke. 1998;29(5):900–907
  34. Agarwal DP. Cardioprotective effects of light–moderate consumption of alcohol: a review of putative mechanisms. Alcohol Alcohol. 2002;37(5):409–415
  35. Djousse L, Arnett DK, Eckfeldt JH, Province MA, Singer MR, Ellison RC. Alcohol consumption and metabolic syndrome: does the type of beverage matter?. Obes Res. 2004;12(9):1375–1385
  36. Fan AZ, Russell M, Dorn J, et al. Lifetime alcohol drinking pattern is related to the prevalence of metabolic syndrome. The Western New York Health Study (WNYHS). Eur J Epidemiol. 2006;21(2):129–138
  37. Kawada T, Okada K. The metabolic syndrome: prevalence and associated lifestyles in Japanese workingmen. J CardioMetabol Synd. 2006;1(5):313–317
  38. Santos AC, Ebrahim S, Barros H. Alcohol intake, smoking, sleeping hours, physical activity and the metabolic syndrome. Prev Med. 2007;44(4):328–334
  39. Botella JGH. Doing and reporting a meta-analysis. Int J Clin Health Psych. 2006;6(2):425–440
  40. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA. 2000;283(15):2008–2012
  41. Corrao G, Bagnardi V, Zambon A, Arico S. Exploring the dose–response relationship between alcohol consumption and the risk of several alcohol-related conditions: a meta-analysis. Addiction. 1999;94(10):1551–1573
  42. Corrao G, Rubbiati L, Bagnardi V, Zambon A, Poikolainen K. Alcohol and coronary heart disease: a meta-analysis. Addiction. 2000;95(10):1505–1523
  43. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1. Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15(7):539–553
  44. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 2001;285(19):2486–97.
  45. Alberti KG, Zimmet P, Shaw J. The metabolic syndrome—a new worldwide definition. Lancet. 2005;366(9491):1059–1062
  46. Wilsgaard T, Jacobsen BK. Lifestyle factors and incident metabolic syndrome. The Tromso Study 1979–2001. Diabetes Res Clin Pract; 2007.
  47. Lee WY, Jung CH, Park JS, Rhee EJ, Kim SW. Effects of smoking, alcohol, exercise, education, and family history on the metabolic syndrome as defined by the ATP III. Diabetes Res Clin Pract. 2005;67(1):70–77
  48. Urashima M, Takashi W, Tsutomu F, et al. Prevalence of metabolic syndrome in a 22,892 Japanese population and its association with life style. JMAJ. 2005;49(9):441–450
  49. Zhu S, St-Onge MP, Heshka S, Heymsfield SB. Lifestyle behaviors associated with lower risk of having the metabolic syndrome. Metabolism. 2004;53(11):1503–1511
  50. Wannamethee SG, Shaper AG, Whincup PH. Modifiable lifestyle factors and the metabolic syndrome in older men: Effects of lifestyle changes. J Am Geriatr Soc. 2006;54(12):1909–1914
  51. Carnethon MR, Loria CM, Hill JO, Sidney S, Savage PJ, Liu K. Risk factors for the metabolic syndrome: the Coronary Artery Risk Development in Young Adults (CARDIA) study, 1985–2001. Diabetes Care. 2004;27(11):2707–2715
  52. Villegas R, Creagh D, Hinchion R, O’Halloran D, Perry IJ. Prevalence and lifestyle determinants of the metabolic syndrome. Ir Med J. 2004;97(10):300–303
  53. Freiberg MS, Cabral HJ, Heeren TC, Vasan RS, Curtis Ellison R. Alcohol consumption and the prevalence of the Metabolic Syndrome in the US.: a cross-sectional analysis of data from the Third National Health and Nutrition Examination Survey. Diabetes Care. 2004;27(12):2954–2959
  54. Rehm J, Klotsche J, Patra J. Comparative quantification of alcohol exposure as risk factor for global burden of disease. Int J Methods Psychiatric Res. 2007;16(2):66–76
  55. Rehm J, Room R, Monteiro M, et al. Alcohol. In:  Ezzati M,  Lopez AD,  Rodgers A,  Murray CJ editor. Comparative quantification of health risks: Global and regional burden of disease due to selected major risk factors. Geneva: WHO; 2004;p. 959–1108
  56. Rehm J, Room R, Monteiro M, et al. Alcohol as a risk factor for global burden of disease. Eur Addict Res. 2003;9(4):157–164
  57. Rosell M, De Faire U, Hellenius ML. Low prevalence of the metabolic syndrome in wine drinkers—is it the alcohol beverage or the lifestyle?. Eur J Clin Nutr. 2003;57(2):227–234
  58. Sterne JA, Egger M. Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. J Clin Epidemiol. 2001;54(10):1046–1055
  59. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629–634
  60. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557–560
  61. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21(11):1539–1558
  62. Dixon JB, Dixon ME, O’Brien PE. Alcohol consumption in the severely obese: relationship with the metabolic syndrome. Obes Res. 2002;10(4):245–252
  63. Liu J, Young TK, Zinman B, Harris SB, Connelly PW, Hanley AJ. Lifestyle variables, non-traditional cardiovascular risk factors, and the metabolic syndrome in an Aboriginal Canadian population. Obesity (Silver Spring). 2006;14(3):500–508
  64. Flanagan DE, Moore VM, Godsland IF, Cockington RA, Robinson JS, Phillips DI. Alcohol consumption and insulin resistance in young adults. Eur J Clin Invest. 2000;30(4):297–301
  65. Beulens JW, van Beers RM, Stolk RP, Schaafsma G, Hendriks HF. The effect of moderate alcohol consumption on fat distribution and adipocytokines. Obesity (Silver Spring). 2006;14(1):60–66
  66. Park HS, Oh SW, Cho SI, Choi WH, Kim YS. The metabolic syndrome and associated lifestyle factors among South Korean adults. Int J Epidemiol. 2004;33(2):328–336
  67. Park YW, Zhu S, Palaniappan L, Heshka S, Carnethon MR, Heymsfield SB. The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988–1994. Arch Intern Med. 2003;163(4):427–436
  68. Lidfeldt J, Nyberg P, Nerbrand C, Samsioe G, Schersten B, Agardh CD. Socio-demographic and psychosocial factors are associated with features of the metabolic syndrome. The Women’s Health in the Lund Area (WHILA) study. Diabetes Obes Metab. 2003;5(2):106–112
  69. Gigleux I, Gagnon J, St-Pierre A, et al. Moderate alcohol consumption is more cardioprotective in men with the metabolic syndrome. J Nutr. 2006;136(12):3027–3032
  70. Williams GD, Aitken SS, Malin H. Reliability of self-reported alcohol consumption in a general population survey. J Stud Alcohol. 1985;46(3):223–227
  71. Giovannucci E, Colditz G, Stampfer MJ, et al. The assessment of alcohol consumption by a simple self-administered questionnaire. Am J Epidemiol. 1991;133(8):810–817
  72. Di Castelnuovo A, Rotondo S, Iacoviello L, Donati MB, De Gaetano G. Meta-analysis of wine and beer consumption in relation to vascular risk. Circulation. 2002;105(24):2836–2844
  73. Burger M, Mensink G, Bronstrup A, Thierfelder W, Pietrzik K. Alcohol consumption and its relation to cardiovascular risk factors in Germany. Eur J Clin Nutr. 2004;58(4):605–614

PII: S0021-9150(08)00770-3

doi: 10.1016/j.atherosclerosis.2008.10.036

Atherosclerosis
Volume 204, Issue 2 , Pages 624-635 , June 2009