Atherosclerosis
Volume 205, Issue 1 , Pages 255-260 , July 2009

25-Hydroxyvitamin D deficiency is independently associated with cardiovascular disease in the Third National Health and Nutrition Examination Survey

  • Jessica Kendrick

      Affiliations

    • Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver, USA
  • ,
  • Giovanni Targher

      Affiliations

    • Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy
  • ,
  • Gerard Smits

      Affiliations

    • Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver, USA
  • ,
  • Michel Chonchol

      Affiliations

    • Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver, USA
    • Corresponding Author InformationCorresponding author at: University of Colorado Health Sciences Center, Division of Renal Diseases and Hypertension, Box C-281, Denver, CO 80262, USA. Tel.: +1 303 399 6997; fax: +1 303 399 3131.

Received 18 July 2008 ,Revised 12 September 2008 ,Accepted 30 October 2008.

References 

  1. Cooper R, Cutler J, Desvigne-Nickens P, et al. Trends and disparities in coronary heart disease, stroke, and other cardiovascular diseases in the United States: findings of the national conference on cardiovascular disease prevention. Circulation. 2000;102:3137–3147
  2. Martins D, Wolf M, Pan D, et al. Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2007;167:1159–1165
  3. Scragg R, Sowers M, Bell C. Serum 25-hydroxyvitamin D, ethnicity, and blood pressure in the Third National Health and Nutrition Examination Survey. Am J Hypertens. 2007;20:713–719
  4. Scragg R, Sowers M, Bell C. Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey. Diabetes Care. 2004;27:2813–2818
  5. de Boer IH, Ioannou GN, Kestenbaum B, Brunzell JD, Weiss NS. 25-Hydroxyvitamin D levels and albuminuria in the Third National Health and Nutrition Examination Survey (NHANES III). Am J Kidney Dis. 2007;50:69–77
  6. Chonchol M, Scragg R. 25-Hydroxyvitamin D, insulin resistance, and kidney function in the Third National Health and Nutrition Examination Survey. Kidney Int. 2007;71:134–139
  7. Krause R, Buhring M, Hopfenmuller W, Holick MF, Sharma AM. Ultraviolet B and blood pressure. Lancet. 1998;352:709–710
  8. Chiu KC, Chu A, Go VL, Saad MF. Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr. 2004;79:820–825
  9. Cigolini M, Iagulli MP, Miconi V, et al. Serum 25-hydroxyvitamin D3 concentrations and prevalence of cardiovascular disease among type 2 diabetic patients. Diabetes Care. 2006;29:722–724
  10. Targher G, Bertolini L, Padovani R, et al. Serum 25-hydroxyvitamin D3 concentrations and carotid artery intima-media thickness among type 2 diabetic patients. Clin Endocrinol. 2006;65:593–597
  11. Wang TJ, Pencina MJ, Booth SL, et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation. 2008;117:503–511
  12. Zittermann A, Schleithoff SS, Tenderich G, et al. Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure?. J Am Coll Cardiol. 2003;41:105–112
  13. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357:266–281
  14. Dusso AS, Brown AJ, Slatopolsky E. Vitamin D. Am J Physiol Renal Physiol. 2005;289:F8–F28
  15. Ritter CS, Armbrecht HJ, Slatopolsky E, Brown AJ. 25-Hydroxyvitamin D(3) suppresses PTH synthesis and secretion by bovine parathyroid cells. Kidney Int. 2006;70:654–659
  16. Stumpf WE, Sar M, Reid FA, Tanaka Y, DeLuca HF. Target cells for 1,25-dihydroxyvitamin D3 in intestinal tract, stomach, kidney, skin, pituitary, and parathyroid. Science. 1979;206:1188–1190
  17. The Third National Health and Nutrition Examination Survey (NHANES III 1988-94) reference manuals and reports [book on CD-ROM]. Bethesda: National Center for Health Statistics; 2002;
  18. National Kidney Foundation: K/DOQI Clinical Practice Guidelines for Chronic Kidney Disease: Evaluation, Classification, and Stratification. Am J Kidney Dis. 2002; 39(Suppl. 1):S1–S266.
  19. Rose GA. The diagnosis of ischemic heart pain and intermittent claudication in field surveys. Bull World Health Organ. 1962;27:645–658
  20. Ford ES, Giles WH. Serum vitamins, carotenoids, and angina pectoris: findings from the National Health and Nutrition Examination Survey III. Ann Epidemiol. 2000;10:106–116
  21. Sorlie PD, Cooper L, Schreiner PJ, et al. Repeatability and validity of the Rose questionnaire for angina pectoris in the Atherosclerosis Risk in Communities Study. J Clin Epidemiol. 1996;49:719–725
  22. Graff-Iverson S, Selmer R, Lochen ML. Rose angina predicts 23-year coronary heart disease mortality in women and men aged 40–49 years. Heart. 2008;94:482–486
  23. Bravata DM, Wells CK, Gulanski B, et al. Racial disparities in stroke risk factors: the impact of socioeconomic status. Stroke. 2005;36:1507–1511
  24. Simon JA, Hudes ES. Serum ascorbic acid and cardiovascular disease prevalence in U.S. adults: the Third National Health and Nutrition Examination Survey (NHANES III). Ann Epidemiol. 1999;9:358–365
  25. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma without the use of the preparative ultracentrifuge. Clin Chem. 1972;18:499–501
  26. Coresh J, Astor BC, Greene T, Eknoyan G, Levey AS. Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey. Am J Kidney Dis. 2003;41:1–12
  27. National Center for Health Statistics . Plan and operation of the Third National Health and Nutrition Examination Survey 1988–1994. Hyattsville, MD: National Center for Health Statistics; 1995;
  28. Shah BV, Barnvell BG, Bieler GS. SUDAAN user's manual version 7.5. Research Triangle Park, NC: Research Triangle Institute; 1997;
  29. Dobnig H, Pilz S, Scharnagl H, et al. Independent association of low serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels with all-cause mortality and cardiovascular mortality. Arch Intern Med. 2008;168:1340–1349
  30. Melamed ML, Michos ED, Post W, Astor B. 25-hydroxyvitamin D levels and the risk of mortality in the general population. Arch Intern Med. 2008;168:1629–1637
  31. Li YC. Vitamin D regulation of the renin–angiotensin system. J Cell Biochem. 2003;88:327–331
  32. Li YC, Kong J, Wei M, et al. 1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin–angiotensin system. J Clin Invest. 2002;110:229–238
  33. Zittermann A, Schleithoff SS, Koerfer R. Putting cardiovascular disease and vitamin D insufficiency into perspective. Br J Nutr. 2005;94:483–492
  34. Rostand SG. Ultraviolet light may contribute to geographic and racial blood pressure differences. Hypertension. 1997;30:150–156
  35. Schleithoff SS, Zittermann A, Tenderich G, et al. Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr. 2006;83:754–759
  36. Jacoby DS, Rader DJ. Renin–angiotensin system and atherothrombotic disease: from genes to treatment. Arch Intern Med. 2003;163:1155–1164
  37. Timms PM, Mannan N, Hitman GA, et al. Circulating MMP9, vitamin D and variation in the TIMP-1 response with VDR genotype: mechanisms for inflammatory damage in chronic disorders?. QJM. 2002;95:787–796
  38. Braam LA, Hoeks AP, Brouns F, et al. Beneficial effects of vitamin D and K on the elastic properties of the vessel wall in postmenopausal women: a follow-up study. Thromb Haemost. 2004;91:373–380
  39. Bergmann MM, Byers T, Freedman DS, Mokdad A. Validity of self-reported diagnoses leading to hospitalization: a comparison of self-reports with hospital records in a prospective study of American adults. Am J Epidemiol. 1998;147:969–977
  40. Walker MK, Whincup PH, Shaper AG, et al. Validation of patient recall of doctor-diagnosed heart attack and stroke: a postal questionnaire and record review comparison. Am J Epidemiol. 1998;148:355–361
  41. Lampe FC, Walker M, Lennon LT, et al. Validity of a self-reported history of doctor-diagnosed angina. J Clin Epidemiol. 1999;52:73–81
  42. St. Sauver JL, Hagen PT, Cha SS, et al. Agreement between patient reports of cardiovascular disease and patient medical records. Mayo Clin Proc. 2005;80:203–210

PII: S0021-9150(08)00773-9

doi: 10.1016/j.atherosclerosis.2008.10.033

Atherosclerosis
Volume 205, Issue 1 , Pages 255-260 , July 2009