Atherosclerosis
Volume 205, Issue 1 , Pages 279-283 , July 2009

Circulating oxidized LDL levels, current smoking and obesity in postmenopausal women

Received 19 May 2008 ,Revised 28 October 2008 ,Accepted 9 November 2008.

References 

  1. Holvoet P, Harris TB, Tracy RP, et al. Association of high coronary heart disease risk status with circulating oxidized LDL in the well-functioning elderly: findings from the Health, Aging, And Body Composition Study. Arterioscler Thromb Vasc Biol. 2003;23:1444–1448
  2. Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med. 1999;340:115–126
  3. Holvoet P, Collen D. Oxidized lipoproteins in atherosclerosis and thrombosis. FASEB J. 1994;8:1279–1284
  4. Toshima S, Hasegawa A, Kurabayashi M, et al. Circulating oxidized low density lipoprotein levels. A biochemical risk marker for coronary heart disease. Arterioscler Thromb Vasc Biol. 2000;20:2243–2247
  5. Ehara S, Ueda M, Naruko T, et al. Elevated levels of oxidized low density lipoprotein show a positive relationship with the severity of acute coronary syndromes. Circulation. 2001;103:1955–1960
  6. Faviou E, Vourli G, Nounopoulos C, Zachari A, Dionyssiou-Asteriou A. Circulating oxidized low density lipoprotein, autoantibodies against them and homocysteine serum levels in diagnosis and estimation of severity of coronary artery disease. Free Radic Res. 2005;39:419–429
  7. Faviou E, Vourli G, Zachari A, Nounopoulos C, Dionyssiou-Asteriou A. Correlation of lipid peroxidation with age, gender and life habits in a healthy Greek population. Free Radic Res. 2005;39(Suppl.):S57
  8. Holvoet P, Jenny NS, Schreiner PJ, Tracy RP, Jacobs DR. The relationship between oxidized LDL and other cardiovascular risk factors and subclinical CVD in different ethnic groups: the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2007;194:245–252
  9. Itabe H, Yamamoto H, Imanaka T, et al. Sensitive detection of oxidatively modified low density lipoprotein using a monoclonal antibody. J Lipid Res. 1996;37:45–53
  10. Ambrose JA, Barua RS. The pathophysiology of cigarette smoking and cardiovascular disease: an update. J Am Coll Cardiol. 2004;43:1731–1737
  11. van Baal WM, Kooistra T, Stehouwer CD. Cardiovascular disease risk and hormone replacement therapy (HRT): a review based on randomised, controlled studies in postmenopausal women. Curr Med Chem. 2000;7:499–517
  12. Signorelli SS, Neri S, Sciacchitano S, et al. Behaviour of some indicators of oxidative stress in postmenopausal and fertile women. Maturitas. 2006;53:77–82
  13. Walsh BW, Schiff I, Rosner B, et al. Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins. N Engl J Med. 1991;325:1196–1204
  14. Deibert P, Koning D, Vitolins MZ, et al. Effect of a weight loss intervention on anthropometric measures and metabolic risk factors in pre- versus postmenopausal women. Nutr J. 2007;6:31
  15. Sowers JR. Obesity as a cardiovascular risk factor. Am J Med. 2003;115(Suppl.):37S–41S
  16. Keaney JF, Larson MG, Vasan RS, et al. Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham study. Arterioscler Thromb Vasc Biol. 2003;23:434–439
  17. Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB. Elevated C-reactive protein levels in overweight and obese adults. JAMA. 1999;282:2131–2135
  18. You T, Ryan AS, Nicklas BJ. The metabolic syndrome in obese postmenopausal women: relationship to body composition, visceral fat, and inflammation. J Clin Endocrinol Metab. 2004;89:5517–5522
  19. Holvoet P, Mertens A, Verhamme P, et al. Circulating oxidized LDL is a useful marker for identifying patients with coronary artery disease. Arterioscler Thromb Vasc Biol. 2001;21:844–848
  20. Bouloumie A, Marumo T, Lafontan M, Busse R. Leptin induces oxidative stress in human endothelial cells. FASEB J. 1999;13:1231–1238
  21. Rosenson RS. Statins in atherosclerosis: lipid-lowering agents with antioxidants capabilities. Atherosclerosis. 2004;173:1–12
  22. Porreca E, Di Febbo C, Moretta V, et al. Circulating leptin is associated with oxidized LDL in postmenopausal women. Atherosclerosis. 2004;175:139–143
  23. Yamagishi SI, Edelstein D, Du XL, et al. Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A. J Biol Chem. 2001;276:25096–25100
  24. Rashid S, Genest J. Effect of obesity on high-density lipoprotein metabolism. Obesity. 2007;15:2875–2888
  25. Sigurdardottir V, Fagerberg B, Hulthe J. Circulating oxidized low-density lipoprotein (LDL) is associated with risk factors of the metabolic syndrome and LDL size in clinically healthy 58-year-old men (AIR study). J Intern Med. 2002;252:440–447
  26. Watson AD, Berliner JA, Hama SY, et al. Protective effect of high density lipoprotein associated paraoxonase: inhibition of the biological activity of minimally oxidized low density lipoprotein. J Clin Invest. 1995;96:2882–2891
  27. Navab M, Berliner JA, Subbanagounder G, et al. HDL and the inflammatory response induced by LDL-derived oxidized phospholipids. Arterioscler Thromb Vasc Biol. 2001;21:481–488
  28. Persegol L, Verges B, Gambert P, Duvillard L. Inability of HDL from abdominally obese subjects to counteract the inhibitory effect of oxidized LDL on vasorelaxation. J Lipid Res. 2007;48:1396–1401
  29. Myara I, Alamowitch C, Michel O, et al. Lipoprotein oxidation and plasma vitamin E in nondiabetic normotensive obese patients. Obes Res. 2003;11:112–120
  30. Monaco C, Crea F, Niccoli G, et al. Autoantibodies against oxidized low density lipoproteins in patients with stable angina, unstable angina or peripheral vascular disease. Eur Heart J. 2001;22:1572–1577
  31. Yla-Herttuala S, Palinski W, Butler SW, et al. Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL. Arterioscler Thromb. 1994;14:32–40
  32. Suzuki K, Ito Y, Ochiai J, et al. The relationship between smoking habits and serum levels of 8-OHdG, oxidized LDL antibodies, Mn-SOD and carotenoids in rural Japanese residents. J Epidemiol. 2003;13:29–37
  33. Wu R, de Faire U, Lemne C, Witztum JL, Frostegard J. Autoantibodies to oxLDL are decreased in individuals with borderline hypertension. Hypertension. 1999;33:53–59
  34. Scott B, Liblau R, Degermann S, et al. A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity. Immunity. 1994;1:73–83
  35. Virella G, Koskinen S, Krings G, et al. Immunochemical characterization of purified human oxidized low density lipoprotein antibodies. Clin Immunol. 2000;95:135–144
  36. Delimaris I, Faviou E, Antonakos G, et al. Oxidized LDL, serum oxidizability and serum lipid levels in patients with breast or ovarian cancer. Clin Biochem. 2007;40:1129–1134
  37. Grundy SM, Pasternak R, Greenland P, Smith S, Fuster V. Assessment of cardiovascular risk by use of multiple-risk-factor assessment equation: a statement for healthcare professionals from the American Heart Association and the American College of Cardiology. Circulation. 1999;100:1481–1492
  38. Bernhard D, Wang XL. Smoking, oxidative stress and cardiovascular diseases do anti-oxidative therapies fail?. Curr Med Chem. 2007;14:1703–1712
  39. Bernhard D, Csordas A, Henderson B, et al. Cigarette smoke metal-catalyzed protein oxidation leads to vascular endothelial cell contraction by depolymerization of microtubules. FASEB J. 2005;19:1096–1107
  40. Yong EL, Li J, Liu MH. Single gene contributions: genetic variants of peroxisome proliferators-activated receptor (isoforms alpha, beta/delta and gamma) and mechanisms of dyslipidemias. Curr Opin Lipidol. 2008;19:106–108

PII: S0021-9150(08)00785-5

doi: 10.1016/j.atherosclerosis.2008.11.006

Atherosclerosis
Volume 205, Issue 1 , Pages 279-283 , July 2009

Article Tools