Atherosclerosis
Volume 205, Issue 1 , Pages 33-34 , July 2009

Interleukin 17: An unlikely marker of acute coronary syndrome?

  • K.D. Patel

      Affiliations

    • Department of Clinical Medicine, Institute of Molecular Medicine, Trinity College, Dublin, Ireland
    • Corresponding Author InformationCorresponding author at: Institute of Molecular Medicine, Trinity Centre For Health Sciences, St James's Hospital, Dublin 8, Ireland. Tel.: +353 1 896 3350; fax: +353 1 454 2043.
    • ,
  • R.T. Murphy

      Affiliations

    • St James's Hospital, Dublin, Ireland
    • ,
  • M. White

      Affiliations

    • Department of Clinical Medicine, Institute of Molecular Medicine, Trinity College, Dublin, Ireland
    • ,
  • D. Gasparro

      Affiliations

    • St James's Hospital, Dublin, Ireland
    • ,
  • D.P. Kelleher

      Affiliations

    • Department of Clinical Medicine, Institute of Molecular Medicine, Trinity College, Dublin, Ireland
    • ,
  • T. Ryan

      Affiliations

    • St James's Hospital, Dublin, Ireland
    • ,
  • R. McManus

      Affiliations

    • Department of Clinical Medicine, Institute of Molecular Medicine, Trinity College, Dublin, Ireland
    • ,
  • A.W. Ryan

      Affiliations

    • Department of Clinical Medicine, Institute of Molecular Medicine, Trinity College, Dublin, Ireland

Received 9 October 2008

References 

  1. Fujino S, Andoh A, Bamba S, et al. Increased expression of interleukin 17 in inflammatory bowel disease. Gut. 2003;52:65–70
  2. Iwakura Y, Ishigame H. The IL-23/IL-17 axis in inflammation. J Clin Invest. 2006;116:1218–1222
  3. Hashmi S, Zeng QT. Role of interleukin-17 and interleukin-17-induced cytokines interleukin-6 and interleukin-8 in unstable coronary artery disease. Coron Artery Dis. 2006;17:699–706
  4. Wang J, Zhang S, Jin Y, et al. Elevated levels of platelet-monocyte aggregates and related circulating biomarkers in patients with acute coronary syndrome. Int J Cardiol. 2007;115:361–365
  5. de Beer FC, Hind CR, Fox KM, et al. Measurement of serum C-reactive protein concentration in myocardial ischaemia and infarction. Br Heart J. 1982;47:239–243
  6. Zhang X, Jin J, Peng X, Ramgolam VS, Markovic-Plese S. Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. J Immunol. 2008;180:6988–6996
  7. Cheng X, Yu X, Ding YJ, et al. The Th17/Treg imbalance in patients with acute coronary syndrome. Clin Immunol. 2008;127:89–97
  8. Ryan AW, O’Brien E, Shields D, McManus R. Lack of association between NFKBIL1/LTA polymorphisms and hypertension, myocardial infarct, unstable angina and stable angina in a large Irish population sample. Atherosclerosis. 2008;197:465–466
  9. Aggarwal S, Gurney AL. IL-17: prototype member of an emerging cytokine family. J Leukoc Biol. 2002;71:1–8

PII: S0021-9150(08)00843-5

doi: 10.1016/j.atherosclerosis.2008.11.022

Atherosclerosis
Volume 205, Issue 1 , Pages 33-34 , July 2009

Article Tools