Atherosclerosis
Volume 205, Issue 1 , Pages 309-313 , July 2009

Insulin resistance and carotid atherosclerosis in patients with type 2 diabetes

  • Seok Won Park

      Affiliations

    • Department of Internal Medicine, Pochon CHA University, 351 Yatapdong, Sungnam 463-712, Republic of Korea
    • Corresponding Author InformationCorresponding author. Tel.: +82 31 780 5211; fax: +82 31 780 5208.
    • ,
  • Soo Kyung Kim

      Affiliations

    • Department of Internal Medicine, Pochon CHA University, 351 Yatapdong, Sungnam 463-712, Republic of Korea
    • ,
  • Yong-Wook Cho

      Affiliations

    • Department of Internal Medicine, Pochon CHA University, 351 Yatapdong, Sungnam 463-712, Republic of Korea
    • ,
  • Dae Jung Kim

      Affiliations

    • Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Republic of Korea
    • ,
  • Young-Duk Song

      Affiliations

    • Department of Medicine, Ilsan Hospital, Goyang, Republic of Korea
    • ,
  • Young Ju Choi

      Affiliations

    • Huh Diabetes Center and the 21st Century Diabetes and Vascular Research Institute, Seoul, Republic of Korea
    • ,
  • Byung Wook Huh

      Affiliations

    • Huh Diabetes Center and the 21st Century Diabetes and Vascular Research Institute, Seoul, Republic of Korea
    • ,
  • Sung Hee Choi

      Affiliations

    • Department of Internal Medicine, Seoul National University, Seoul, Republic of Korea
    • ,
  • Sun Ha Jee

      Affiliations

    • Department of Epidemiology, Graduate School of Public Health, Yonsei University, Seoul, Republic of Korea
    • ,
  • Mi Ae Cho

      Affiliations

    • Department of Medicine, Yonsei University, Seoul, Republic of Korea
    • ,
  • Eun Jig Lee

      Affiliations

    • Department of Medicine, Yonsei University, Seoul, Republic of Korea
    • ,
  • Kap Bum Huh

      Affiliations

    • Huh Diabetes Center and the 21st Century Diabetes and Vascular Research Institute, Seoul, Republic of Korea

Received 20 May 2008 ,Revised 20 November 2008 ,Accepted 4 December 2008.

References 

  1. Weyer C, Bogardus C, Mott DM, Pratley RE. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest. 1999;104:787–794
  2. Bonora E, Kiechl S, Willeit J, et al. Population-based incidence rates and risk factors for type 2 diabetes in white individuals: the Bruneck Study. Diabetes. 2004;53:1782–1789
  3. Reaven GM. Role of insulin resistance in human disease. Diabetes. 1988;37:1595–1607
  4. DeFronzo RA, Ferrannini E. Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care. 1991;14:173–194
  5. Bonora E, Kiechl S, Willeit J, et al. Metabolic syndrome: epidemiology and more extensive phenotypic description. Int J Obes Relat Metab Disord. 2003;27:1283–1289
  6. Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults: executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 2001;285:2486–97.
  7. World Health Organization . Guidelines for the prevention, management and care of diabetes mellitus. Geneva: World Health Org.; 2006;(EMRO Technical Publications Series 32).
  8. Alberti KGMM, Zimmet PZ, Shaw JE. The metabolic syndrome—a new worldwide definition from the International Diabetes Federation Consensus. Lancet. 2005;366:1059–1062
  9. Geiss LS, Herman WH, Smith PJ. Mortality in non-insulin dependent diabetes mellitus. In:  Bethesda MD editors. Diabetes in America. 2nd ed.. National Institutes of Health; 1995;(NIH publ. nos. 95–1468)
  10. Stern MP. Diabetes and cardiovascular disease. The common soil hypothesis. Diabetes. 1995;44:369–374
  11. Lebovitz HE. Insulin resistance—a common link between type 2 diabetes and cardiovascular disease. Diabetes Obes Metab. 2006;8:237–249
  12. Hanley AJ, Williams K, Stern MP, Haffner SM. Homeostasis model assessment of insulin resistance in relation to the incidence of cardiovascular disease. Diabetes Care. 2002;25:1177–1184
  13. Bonora E, Moghetti P, Zancanaro C, et al. Estimates of in vivo insulin action in man: comparison of insulin tolerance tests with euglycemic and hyperglycemic glucose clamp studies. J Clin Endocrinol Metab. 1989;68:374–378
  14. Young RP, Critchley JA, Anderson PJ, Lau MS, Lee KK, Chan JC. The short insulin tolerance test: feasibility study using venous sampling. Diabet Med. 1996;13:429–433
  15. Alberti KGGM, Daly ME, Robibson A, Marshall SM, Maathers JC. The short insulin tolerance test is safe and reproducible. Diabet Med. 1999;16:352–353
  16. Park SW, Yun YS, Ahn CW, et al. Short insulin tolerance test for the determination of in vivo insulin sensitivity: a comparison with euglycemic clamp test. Kor Diabetes J. 1998;22:199–208
  17. Watarai T, Yamasaki Y, Ikeda M, et al. Insulin resistance contributes to carotid arterial wall thickness in patients with non-insulin-dependent-diabetes mellitus. Endocr J. 1999;46:629–638
  18. Cardellini M, Marini MA, Frontoni S, et al. Carotid artery intima-media thickness is associated with insulin-mediated glucose disposal in nondiabetic normotensive offspring of type 2 diabetic patients. Am J Physiol Endocrinol Metab. 2007;292:E347–352
  19. Bonora E, Kiechl S, Willeit J, et al. Insulin resistance as estimated by homeostasis model assessment predicts incident symptomatic cardiovascular disease in Caucasian subjects from the general population. Diabetes Care. 2007;30:318–324
  20. Yip J, Facchini FS, Reaven GM. Resistance to insulin-mediated glucose disposal as a predictor of cardiovascular disease. J Clin Endocrinol Metab. 1998;83:2773–2776
  21. Raajala U, Laakso M, Paivansalo M, Pelkonen O, Suramo I, Keinanen-Kiukaanniemi S. Low insulin sensitivity measured by both quantitative insulin sensitivity check index and homeostasis model assessment method as a risk factor of increased intima-media thickness of the carotid artery. J Clin Endocrinol Metab. 2002;87:5092–5097
  22. Bonora E, Tessari R, Micciolo R, et al. Intima-medial thickness of the carotid artery in nondiabetic and NIDDM patients. Relationship with insulin resistance. Diabetes Care. 1997;24:627–631
  23. Rutter MK, Meigs JB, Sullivan LM, D’Agostino RB, Wilson PW. Insulin resistance, the metabolic syndrome, and incident cardiovascular events in the Framingham offspring study. Diabetes. 2005;54:3252–3257
  24. Ishizaka N, Ishizaka Y, Takahashi E, et al. Association between insulin resistance and carotid arteriosclerosis in subjects with normal fasting glucose and normal glucose tolerance. Arterioscler Throm Vasc Biol. 2003;23:295–301
  25. Larsson H, Berglund G, Ahren B. Insulin sensitivity, insulin secretion, and glucose tolerance versus intima-media thickness in nondiabetic postmenopausal women. J Clin Endocrinol Metab. 2003;88:4791–4797
  26. Ferrara A, Barrett-Connor EL, Edelstein SL. Hyperinsulinemia does not increase the risk of fatal cardiovascular disease in elderly men or women without diabetes: the Rancho Bernardo Study. Am J Epidemiol. 1994;140:857–869
  27. Wallace TM, Levy JC, Matthews DR. Use and abuse of HOMA modeling. Diabetes Care. 2004;27:1487–1495
  28. Muniyappa R, Lee S, Chen H, Quon MJ. Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage. Am J Physiol Endocrinol Metab. 2008;294:E15–26
  29. Kang ES, Yun YS, Park SW, et al. Limitation of the validity of the homeostasis model assessment as an index of insulin resistance in Korea. Metabolism. 2005;54:206–211
  30. Kim DJ, Song KE, Park JW, Cho HK, Lee KW, Huh KB. Clinical characteristics of Korean type 2 diabetic patients in 2005. Diabetes Res Clin Pract. 2007;77S:S252–S257
  31. Howard G, O’Leary DH, Zaccaro S, et al. Insulin sensitivity and atherosclerosis. Circulation. 1996;93:1809–1817
  32. Haffner SM, D’Agostino R, Mykkänen L, et al. Proinsulin and insulin concentrations in relation to carotid wall thickness: insulin resistance atherosclerosis study. Stroke. 1998;29:1498–1503

☆ This study was supported by Seoul City R&BD Program (10526), Seoul, Republic of Korea.

PII: S0021-9150(08)00849-6

doi: 10.1016/j.atherosclerosis.2008.12.006

Atherosclerosis
Volume 205, Issue 1 , Pages 309-313 , July 2009

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