Atherosclerosis
Volume 205, Issue 2 , Pages 620-625 , August 2009

Leukocyte telomere length is associated with HDL cholesterol levels: The Bogalusa heart study

  • Wei Chen

      Affiliations

    • Tulane Center for Cardiovascular Health, Tulane University Health Sciences, New Orleans, LA 70112, United States
    • Corresponding Author InformationCorresponding author at: 1440 Canal Street, Room 1829, New Orleans, LA 70112, United States. Tel.: +1 504 988 7197; fax: +1 504 988 7194.
    • ,
  • Jeffrey P. Gardner

      Affiliations

    • The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, United States
    • ,
  • Masayuki Kimura

      Affiliations

    • The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, United States
    • ,
  • Michael Brimacombe

      Affiliations

    • The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, United States
    • ,
  • Xiaojian Cao

      Affiliations

    • The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, United States
    • ,
  • Sathanur R. Srinivasan

      Affiliations

    • Tulane Center for Cardiovascular Health, Tulane University Health Sciences, New Orleans, LA 70112, United States
    • ,
  • Gerald S. Berenson

      Affiliations

    • Tulane Center for Cardiovascular Health, Tulane University Health Sciences, New Orleans, LA 70112, United States
    • ,
  • Abraham Aviv

      Affiliations

    • The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, United States

Received 21 November 2008 ,Revised 14 January 2009 ,Accepted 14 January 2009.

References 

  1. Gordon DJ, Rifkind BM. High-density lipoprotein—the clinical implications of recent studies. N Engl J Med. 1989;321:1311–1316
  2. Assmann G, Schulte H, von Eckardstein A, Huang Y. High-density lipoprotein cholesterol as a predictor of coronary heart disease risk. The PROCAM experience and pathophysiological implications for reverse cholesterol transport. Atherosclerosis. 1996;124(Suppl.):S11–20
  3. Nicholls SJ, Tuzcu EM, Sipahi I, et al. Statins, high-density lipoprotein cholesterol, and regression of coronary atherosclerosis. JAMA. 2007;297:499–508
  4. Castelli WP, Garrison RJ, Wilson PW, et al. Incidence of coronary heart disease and lipoprotein cholesterol levels. The Framingham Study. JAMA. 1986;256:2835–2838
  5. Hansson GK, Libby P. The immune response in atherosclerosis: a double-edged sword. Nat Rev Immunol. 2006;6:508–519
  6. Gutierrez J, Ballinger SW, Darley-Usmar VM, Landar A. Free radicals, mitochondria, and oxidized lipids: the emerging role in signal transduction in vascular cells. Circ Res. 2006;99:924–932
  7. Norata GD, Catapano AL. Molecular mechanisms responsible for the antiinflammatory and protective effect of HDL on the endothelium. Vasc Health Risk Manage. 2005;1:119–129
  8. Negre-Salvayre A, Dousset N, Ferretti G, et al. Antioxidant and cytoprotective properties of high-density lipoproteins in vascular cells. Free Radic Biol Med. 2006;41:1031–1040
  9. Ansell BJ. Targeting the anti-inflammatory effects of high-density lipoprotein. Am J Cardiol. 2007;100(11 A):n3–9
  10. Aviv A. Telomeres and human somatic fitness. J Gerontol A Biol Sci Med Sci. 2006;61:871–873
  11. Benetos A, Gardner JP, Zureik M, et al. Short telomeres are associated with increased carotid artery atherosclerosis in hypertensive subjects. Hypertension. 2004;43:182–185
  12. Brouilette S, Singh RK, Thompson JR, Goodall AH, Samani NJ. White cell telomere length and risk of premature myocardial infarction. Arterioscler Throm Vasc Biol. 2003;23:842–846
  13. Brouilette SW, Moore JS, McMahon AD, et al. Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study. The Lancet. 2007;369:107–114
  14. ODonnell CJ, Demissie S, Kimura M, et al. Leukocyte telomere length and carotid artery intimal medial thickness: The Framingham Heart Study. Arterioscler Thromb Vasc Biol. 2008;28:1165–1171
  15. Adaikalakoteswari A, Balasubramanyam M, Mohan V. Telomere shortening occurs in Asian Indian Type 2 diabetic patients. Diabet Med. 2005;22:1151–1156
  16. Adaikalakoteswari A, Balasubramanyam M, Ravikumar R, Deepa R, Mohan V. Association of telomere shortening with impaired glucose tolerance and diabetic macroangiopathy. Atherosclerosis. 2007;195:83–89
  17. Nordfjäll K, Eliasson M, Stegmayr B, Melander O, Nilsson P. Roos G telomere length is associated with obesity parameters but with a gender difference. Obesity (Silver Spring). 2008;September 25 [Epub ahead of print]
  18. Berenson GS, McMahan CA, Voors AW, et al. Cardiovascular risk factors in children. The early natural history of atherosclerosis and essential hypertension. Oxford: Oxford University Press; 1980;p. 47–123
  19. Srinivasan SR, Berenson GS. Serum lipoproteins in children and methods for study. In:  Lewis LA editors. CRC handbook of electrophoresis, vol III: lipoprotein methodology and human studies. Boca Raton, FL: CRC Press; 1983;p. 185–204
  20. Hunt SC, Chen W, Gardner JP, et al. Leukocyte telomeres are longer in African Americans than in Whites: The NHLBI Family Heart Study and the Bogalusa Heart Study. Aging Cell. 2008;7:451–458
  21. SAS Institute: SAS/STAT Software: changes and enhancements through release 6.12. Cary, NC: SAS Institute; 1997.
  22. Cook NJ, Rosner BA, Chen W, Srinivasan SR, Berenson GS. Using area under the curve to predict adult blood pressure from childhood measures in the Bogalusa Heart Study. Stat Med. 2004;23:3421–3435
  23. Chen W, Li S, Cook NR, et al. An autosomal genome scan for loci linked to longitudinal burden of body mass index from childhood to young adulthood in white sibships: The Bogalusa heart study. Int J Obesity. 2004;28:462–469
  24. Aviv A, Chen W, Kimura M, et al. Leukocyte telomere dynamics: longitudinal findings in young adults of the Bogalusa heart study. Am J Epidemiol. 2008;December 4 [Epub ahead of print]
  25. Ghandehari H, Kamal-Bahl S, Wong ND. Prevalence and extent of dyslipidemia and recommended lipid levels in US adults with and without cardiovascular comorbidities: the National Health and Nutrition Examination Survey 2003–2004. Am Heart J. 2008;156:112–119
  26. Aviv A. The epidemiology of human telomeres: faults and promises. J Gerontol A Biol Sci Med Sci. 2008;63:979–983
  27. Olovnikov AM. Telomeres, telomerase, and aging: origin of the theory. Exp Gerontol. 1996;31:443–448
  28. Martens UM, Zijlmans JM, Poon SS, et al. Short telomeres on human chromosome 17p. Nat Genet. 1998;18:76–80
  29. von Zglinicki T. Role of oxidative stress in telomere length regulation and replicative senescence. Ann NY Acad Sci. 2000;908:99–110
  30. Hall DB, Holmlin RE, Barton JK. Oxidative DNA damage through long-range electron transfer. Nature. 1996;382:731–735
  31. Saretzki G, Sitte N, Merkel U, Wurm RE, von Zglinicki T. Telomere shortening triggers p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments. Oncogene. 1999;18:5148–5158
  32. Tchirkov A, Lansdorp PM. Role of oxidative stress in telomere shortening in cultured fibroblasts from normal individuals and patients with ataxia-telangiectasia. Hum Mol Genet. 2003;12:227–232
  33. Sitte N, Saretzki G, von Zglinicki T. Accelerated telomere shortening in fibroblasts after extended periods of confluency. Free Radic Biol Med. 1998;24:885–893
  34. Serra V, von Zglinicki T, Lorenz M, Saretzki G. Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening. J Biol Chem. 2003;278:6824–6830
  35. Kimura M, Cao X, Skurnick J, et al. Proliferation dynamics in cultured skin fibroblasts from Down syndrome. Free Radic Biol Med. 2005;39:374–380
  36. Baird DM, Rowson J, Wynford-Thomas D, Kipling D. Extensive allelic variation and ultra-short telomeres in senescent human cells. Nat Genet. 2003;33:203–207
  37. Baird DM, Britt-Compton B, Rowson J, et al. Telomere instability in the male germline. Hum Mol Genet. 2006;15:45–51
  38. Kimura M, Barbieri M, Gardner JP, et al. Leukocytes of exceptionally old persons display ultra-short telomeres. Am J Physiol Regul Integr Comp Physiol. 2007;293:R2210–2217

☆ The current study has been supported by the following grants: 0855082E from American Heart Association, HL-38844 from the National Heart, Lung, Blood Institute, and AG16592 and AG020132 from the National Institute on Aging.

PII: S0021-9150(09)00068-9

doi: 10.1016/j.atherosclerosis.2009.01.021

Atherosclerosis
Volume 205, Issue 2 , Pages 620-625 , August 2009

Article Tools

* Image Usage & Resolution