Atherosclerosis
Volume 206, Issue 2 , Pages 369-374 , October 2009

CD44-deficiency on hematopoietic cells limits T-cell number but does not protect against atherogenesis in LDL receptor-deficient mice

  • Sara Sjöberg

      Affiliations

    • Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    • ,
  • Einar E. Eriksson

      Affiliations

    • Dept. of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
    • ,
  • Åsa Tivesten

      Affiliations

    • Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    • ,
  • Annelie Carlsson

      Affiliations

    • Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    • ,
  • Anna Klasson

      Affiliations

    • Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    • ,
  • Max Levin

      Affiliations

    • Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    • ,
  • Jan Borén

      Affiliations

    • Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    • ,
  • Alexandra Krettek

      Affiliations

    • Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    • Nordic School of Public Health, Gothenburg, Sweden
    • Corresponding Author InformationCorresponding author at: Nordic School of Public Health, Box 12133, 402 42 Gothenburg, Sweden. Tel.: +46 31 693966; fax: +46 31 691777.

Received 19 June 2008 ,Revised 6 March 2009 ,Accepted 7 March 2009.

References 

  1. Evanko SP, Raines EW, Ross R, et al. Proteoglycan distribution in lesions of atherosclerosis depends on lesion severity, structural characteristics, and the proximity of platelet-derived growth factor and transforming growth factor-beta. Am J Pathol. 1998;152:533–546
  2. Vivers S, Dransfield I, Hart SP. Role of macrophage CD44 in the disposal of inflammatory cell corpses. Clin Sci (Lond). 2002;103:441–449
  3. McKee CM, Penno MB, Cowman M, et al. Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. The role of HA size and CD44. J Clin Invest. 1996;98:2403–2413
  4. Guo Y, Wu Y, Shinde S, et al. Identification of a costimulatory molecule rapidly induced by CD40L as CD44H. J Exp Med. 1996;184:955–961
  5. Krettek A, Sukhova GK, Schonbeck U, et al. Enhanced expression of CD44 variants in human atheroma and abdominal aortic aneurysm: possible role for a feedback loop in endothelial cells. Am J Pathol. 2004;165:1571–1581
  6. Hagg D, Sjoberg S, Hulten LM, et al. Augmented levels of CD44 in macrophages from atherosclerotic subjects: A possible IL-6-CD44 feedback loop?. Atherosclerosis. 2007;190:291–297
  7. Cuff CA, Kothapalli D, Azonobi I, et al. The adhesion receptor CD44 promotes atherosclerosis by mediating inflammatory cell recruitment and vascular cell activation. J Clin Invest. 2001;108:1031–1040
  8. Zhao L, Lee E, Zukas AM, et al. CD44 expressed on both bone marrow-derived and non-bone marrow-derived cells promotes atherogenesis in ApoE-deficient mice. Arterioscler Thromb Vasc Biol. 2008;28:1283–1289
  9. Han S, Liang CP, DeVries-Seimon T, et al. Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions. Cell Metab. 2006;3:257–266
  10. Kanters E, Pasparakis M, Gijbels MJ, et al. Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice. J Clin Invest. 2003;112:1176–1185
  11. Nettleship JE, Jones TH, Channer KS, et al. Physiological testosterone replacement therapy attenuates fatty streak formation and improves high-density lipoprotein cholesterol in the Tfm mouse: an effect that is independent of the classic androgen receptor. Circulation. 2007;116:2427–2434
  12. Gustafsson M, Levin M, Skalen K, et al. Retention of low-density lipoprotein in atherosclerotic lesions of the mouse: evidence for a role of lipoprotein lipase. Circ Res. 2007;101:777–783
  13. Persson L, Boren J, Robertson AK, et al. Lack of complement factor C3, but not factor B, increases hyperlipidemia and atherosclerosis in apolipoprotein E−/− low-density lipoprotein receptor−/− mice. Arterioscler Thromb Vasc Biol. 2004;24:1062–1067
  14. Sukhova GK, Wang B, Libby P, et al. Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice. Circ Res. 2005;96:368–375
  15. Eriksson EE, Xie X, Werr J, et al. Importance of primary capture and l-selectin-dependent secondary capture in leukocyte accumulation in inflammation and atherosclerosis in vivo. J Exp Med. 2001;194:205–218
  16. Joven J, Rull A, Ferre N, et al. The results in rodent models of atherosclerosis are not interchangeable: the influence of diet and strain. Atherosclerosis. 2007;195:e85–92
  17. Vergnes L, Phan J, Strauss M, et al. Cholesterol and cholate components of an atherogenic diet induce distinct stages of hepatic inflammatory gene expression. J Biol Chem. 2003;278:42774–42784
  18. Kim Y, Lee YS, Hahn JH, et al. Hyaluronic acid targets CD44 and inhibits FcepsilonRI signaling involving PKCdelta, Rac1, ROS, and MAPK to exert anti-allergic effect. Mol Immunol. 2008;45:2537–2547
  19. Miyata M, Smith JD. Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides. Nat Genet. 1996;14:55–61
  20. Foger N, Marhaba R, Zoller M. CD44 supports T cell proliferation and apoptosis by apposition of protein kinases. Eur J Immunol. 2000;30:2888–2899
  21. Pepe MG, Curtiss LK. Apolipoprotein E is a biologically active constituent of the normal immunoregulatory lipoprotein. LDL-In. J Immunol. 1986;136:3716–3723
  22. Curtiss LK, Boisvert WA. Apolipoprotein E and atherosclerosis. Curr Opin Lipidol. 2000;11:243–251
  23. Gee K, Kryworuchko M, Kumar A. Recent advances in the regulation of CD44 expression and its role in inflammation and autoimmune diseases. Arch Immunol Ther Exp (Warsz). 2004;52:13–26
  24. Potteaux S, Combadiere C, Esposito B, et al. Role of bone marrow-derived CC-chemokine receptor 5 in the development of atherosclerosis of low-density lipoprotein receptor knockout mice. Arterioscler Thromb Vasc Biol. 2006;26:1858–1863
  25. Zernecke A, Liehn EA, Gao JL, et al. Deficiency in CCR5 but not CCR1 protects against neointima formation in atherosclerosis-prone mice: involvement of IL-10. Blood. 2006;107:4240–4243
  26. Braunersreuther V, Zernecke A, Arnaud C, et al. Ccr5 but not Ccr1 deficiency reduces development of diet-induced atherosclerosis in mice. Arterioscler Thromb Vasc Biol. 2007;27:373–379
  27. Khan AI, Kerfoot SM, Heit B, et al. Role of CD44 and hyaluronan in neutrophil recruitment. J Immunol. 2004;173:7594–7601
  28. Zhao L, Hall JA, Levenkova N, et al. CD44 regulates vascular gene expression in a proatherogenic environment. Arterioscler Thromb Vasc Biol. 2007;4:886–892
  29. Termeer C, Averbeck M, Hara H, et al. Targeting dendritic cells with CD44 monoclonal antibodies selectively inhibits the proliferation of naive CD4+T-helper cells by induction of FAS-independent T-cell apoptosis. Immunology. 2003;109:32–40
  30. Liang J, Jiang D, Griffith J, et al. CD44 is a negative regulator of acute pulmonary inflammation and lipopolysaccharide-TLR signaling in mouse macrophages. J Immunol. 2007;178:2469–2475

PII: S0021-9150(09)00207-X

doi: 10.1016/j.atherosclerosis.2009.03.002

Atherosclerosis
Volume 206, Issue 2 , Pages 369-374 , October 2009

Article Tools

* Image Usage & Resolution