Atherosclerosis
Volume 206, Issue 2 , Pages 353-354, October 2009

Statin pleiotropism and atherosclerotic plaque rupture

Bristol Heart Institute, University of Bristol, Level 7, Bristol Royal Infirmary, Bristol BS2 8HW, United Kingdom

Received 30 March 2009 published online 08 May 2009.

Abstract 

To be attributed with pleiotropism, statins need to show effects that are unrelated to plasma lipid lowering. In the studies of Nakamura et al. using fluvastatin, it is not clear that this was unequivocally the case. Furthermore, the observed effects of fluvastatin treatment on plaque stability may have been distorted by a potential effect of the drug on fibrinolysis. We conclude that more studies are required before it will be possible to say that fluvastatin influences plaque stability in this mouse model through a non-lipid-lowering mechanism.

Keywords: Apolipoprotein E knockout mouse, Statin, Plaque rupture, Pleiotropism

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PII: S0021-9150(09)00262-7

doi:10.1016/j.atherosclerosis.2009.03.050

Atherosclerosis
Volume 206, Issue 2 , Pages 353-354, October 2009

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