Atherosclerosis
Volume 207, Issue 1 , Pages 131-138 , November 2009

Effects of Schistosoma mansoni worms and eggs on circulating cholesterol and liver lipids in mice

  • Ronald G. Stanley

      Affiliations

    • School of Biological Sciences, University of Reading, Whiteknights, Reading, BERKS RG6 6UB, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44 (0)118 3785209.
    • ,
  • Christopher L. Jackson

      Affiliations

    • Bristol Heart Institute, University of Bristol, Bristol BS2 8HW, UK
    • ,
  • Keith Griffiths

      Affiliations

    • Ysbyty Gwynedd, Bangor LL57 2PW, UK
    • ,
  • Michael J. Doenhoff

      Affiliations

    • School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK

Received 15 September 2008 ,Revised 22 April 2009 ,Accepted 27 April 2009.

References 

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  3. Smithers SR, Terry RJ. The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of adult worms. Parasitology. 1965;55:695–700
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  5. Doenhoff MJ, Pearson S, Dunne DW, et al. Immunological control of hepatotoxicity and parasite egg excretion in Schistosoma mansoni infections: stage specificity of the reactivity of immune serum in T-cell deprived mice. Trans R Soc Trop Med Hyg. 1981;75:41–53
  6. Ashton PD, Harrop R, Shah B, Wilson RA. The schistosome egg: development and secretions. Parasitology. 2001;122:329–338
  7. Dunne DW, Agnew AM, Modha J, Doenhoff MJ. Schistosoma mansoni egg antigens: preparation of rabbit antisera with monospecific immunoprecipitating activity, and their use in antigen characterization. Parasite Immunol. 1986;8:575–586
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  14. Meyer F, Meyer H, Bueding E. Lipid metabolism in the parasitic and free-living flatworms, Schistosoma mansoni and Dugesia dorotocephala. Biochim Biophys Acta. 1970;210:257–266
  15. Tempone AJ, Bianconi ML, Rumjanek FD. The interaction of human LDL with the tegument of adult Schistosoma mansoni. Mol Cell Biochem. 1997;177:139–144
  16. Sprong H, Suchanek M, van Dijk SM, et al. Aberrant receptor-mediated endocytosis of Schistosoma mansoni glycoproteins on host lipoproteins. PLoS Med. 2006;3:1360–1370
  17. Pearce EJ, Caspar P, Grzych J-M, Lewis FA, Sher A. Downregulation of Thl cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni. J Exp Med. 1991;173:159–166
  18. Schramm G, Falcone FH, Gronow A, et al. Molecular characterization of an interleukin-4-inducing factor from Schistosoma mansoni eggs. J Biol Chem. 2003;278:18384–18392
  19. van der Kleij D, Latz E, Brouwers JF, et al. A novel host–parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization. J Biol Chem. 2002;277:48122–48129
  20. Li Z, Soloski MJ, Diehl AM. Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease. Hepatology. 2000;31:633–640
  21. Tedgui A, Mallat Z. Cytokines in atherosclerosis: pathogenic and regulatory pathways. Physiol Rev. 2006;86:515–581
  22. Schramm G, Gronow A, Knobloch J, et al. IPSE/alpha-1: a major immunogenic component secreted from Schistosoma mansoni eggs. Mol Biochem Parasitol. 2006;147:9–19
  23. La Flamme AC, Harvie M, Kenwright D, et al. Chronic exposure to schistosome eggs reduces cholesterol but has no effect on atherosclerotic lesion development. Parasite Immunol. 2006;29:259–266
  24. Schwarz M, Russell DW, Dietschy JM, Turley SD. Marked reduction in bile acid synthesis in cholesterol 7a-hydroxylase-deficient mice does not lead to diminished tissue cholesterol turnover or to hypercholesterolemia. J Lipid Res. 1998;39:1834–1843
  25. British Heart Foundation Coronary heart disease statistics at www.heartstats.org.

PII: S0021-9150(09)00330-X

doi: 10.1016/j.atherosclerosis.2009.04.037

Atherosclerosis
Volume 207, Issue 1 , Pages 131-138 , November 2009

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