Atherosclerosis
Volume 209, Issue 1 , Pages 51-57 , March 2010

EMMPRIN and its ligand cyclophilin A regulate MT1-MMP, MMP-9 and M-CSF during foam cell formation

  • Peter Seizer

      Affiliations

    • Medizinische Klinik III, Eberhard Karls University Tuebingen, Germany
  • ,
  • Tanja Schönberger

      Affiliations

    • Medizinische Klinik III, Eberhard Karls University Tuebingen, Germany
  • ,
  • Moritz Schött

      Affiliations

    • Medizinische Klinik III, Eberhard Karls University Tuebingen, Germany
  • ,
  • Michael R. Lang

      Affiliations

    • Medizinische Klinik III, Eberhard Karls University Tuebingen, Germany
  • ,
  • Harald F. Langer

      Affiliations

    • Medizinische Klinik III, Eberhard Karls University Tuebingen, Germany
  • ,
  • Boris Bigalke

      Affiliations

    • Medizinische Klinik III, Eberhard Karls University Tuebingen, Germany
  • ,
  • Björn F. Krämer

      Affiliations

    • Medizinische Klinik III, Eberhard Karls University Tuebingen, Germany
  • ,
  • Oliver Borst

      Affiliations

    • Medizinische Klinik III, Eberhard Karls University Tuebingen, Germany
  • ,
  • Karin Daub

      Affiliations

    • Medizinische Klinik III, Eberhard Karls University Tuebingen, Germany
  • ,
  • Olaf Heidenreich

      Affiliations

    • Newcastle University, Northern Institute for Cancer Research, United Kingdom
  • ,
  • Roland Schmidt

      Affiliations

    • Medizinische Klinik I, Klinikum rechts der Isar, Technische Universität München, Germany
  • ,
  • Stephan Lindemann

      Affiliations

    • Medizinische Klinik III, Eberhard Karls University Tuebingen, Germany
  • ,
  • Yared Herouy

      Affiliations

    • Department of Dermatology, University of Freiburg, Germany
  • ,
  • Meinrad Gawaz

      Affiliations

    • Medizinische Klinik III, Eberhard Karls University Tuebingen, Germany
  • ,
  • Andreas E. May

      Affiliations

    • Medizinische Klinik III, Eberhard Karls University Tuebingen, Germany
    • Corresponding Author InformationCorresponding author at: Medizinische Klinik III, Universitätsklinikum Tübingen, Otfried-Müller Str.10, 72076 Tübingen, Germany. Tel.: +49 7071 29 83160; fax: +49 7071 29 4473.

Received 16 March 2009 ,Revised 27 July 2009 ,Accepted 17 August 2009.

References 

  1. Shashkin P, Dragulev B, Ley K. Macrophage differentiation to foam cells. Curr Pharm Des. 2005;11(23):3061–3072
  2. Moreno PR, Falk E, Palacios IF, et al. Macrophage infiltration in acute coronary syndromes. Implications for plaque rupture. Circulation. 1994;90(2):775–778
  3. Hristov M, Erl W, Weber PC. Endothelial progenitor cells: mobilization, differentiation, and homing. Arterioscler Thromb Vasc Biol. 2003;23(July (7)):1185–1189
  4. Daub K, Langer H, Seizer P, et al. Platelets induce differentiation of human CD34+ progenitor cells into foam cells and endothelial cells. FASEB J. 2006;20(14):2559–2561
  5. Langer H, May AE, Daub K, et al. Adherent platelets recruit and induce differentiation of murine embryonic endothelial progenitor cells to mature endothelial cells in vitro. Circ Res. 2006;98(February (2)):e2–e10
  6. Stellos K, Langer H, Daub K, et al. Platelet-derived stromal cell-derived factor-1 regulates adhesion and promotes differentiation of human CD34+ cells to endothelial progenitor cells. Circulation. 2008;117(January (2)):206–215
  7. Zampetaki A, Kirton JP, Xu Q. Vascular repair by endothelial progenitor cells. Cardiovasc Res. 2008;78(June (3)):413–421
  8. Brown DL, Hibbs MS, Kearney M, Loushin C, Isner JM. Identification of 92-kD gelatinase in human coronary atherosclerotic lesions. Association of active enzyme synthesis with unstable angina. Circulation. 1995;91(April (8)):2125–2131
  9. Schmidt R, Bultmann A, Ungerer M, et al. Extracellular matrix metalloproteinase inducer regulates Matrix MetalloProteinase activity in cardiovascular cells: implications in acute myocardial infarction. Circulation. 2006;113(February (6)):834–841
  10. Toole BP. Emmprin (CD147), a cell surface regulator of Matrix MetalloProteinase production and function. Curr Top Dev Biol. 2003;54:371–389
  11. Li R, Huang L, Guo H, Toole BP. Basigin (murine EMMPRIN) stimulates Matrix MetalloProteinase production by fibroblasts. J Cell Physiol. 2001;186(3):371–379
  12. Sun J, Hemler ME. Regulation of MMP-1 and MMP-2 production through CD147/extracellular matrix metalloproteinase inducer interactions. Cancer Res. 2001;61(March (5)):2276–2281
  13. Schmidt R, Bultmann A, Fischel S, et al. Extracellular matrix metalloproteinase inducer (CD147) is a novel receptor on platelets, activates platelets, and augments nuclear factor {kappa}B dependent inflammation in monocytes. Circ Res. 2008;102(November (3)):302–309
  14. Yurchenko V, Constant S, Bukrinsky M. Dealing with the family: CD147 interactions with cyclophilins. Immunology. 2006;117(3):301–309
  15. Yurchenko V, O’Connor M, Dai WW, et al. CD147 is a signaling receptor for cyclophilin B. Biochem Biophys Res Commun. 2001;288(November (4)):786–788
  16. Jin ZG, Melaragno MG, Liao DF, et al. Cyclophilin A is a secreted growth factor induced by oxidative stress. Circ Res. 2000;87(October (9)):789–796
  17. Sherry B, Yarlett N, Strupp A, Cerami A. Identification of cyclophilin as a proinflammatory secretory product of lipopolysaccharide-activated macrophages. Proc Natl Acad Sci U S A. 1992;89(April (8)):3511–3515
  18. Seko Y, Fujimura T, Taka H, et al. Hypoxia followed by reoxygenation induces secretion of cyclophilin A from cultured rat cardiac myocytes. Biochem Biophys Res Commun. 2004;317(April (1)):162–168
  19. Major TC, Liang L, Lu X, Rosebury W, Bocan TM. Extracellular matrix metalloproteinase inducer (EMMPRIN) is induced upon monocyte differentiation and is expressed in human atheroma. Arterioscler Thromb Vasc Biol. 2002;22(July (7)):1200–1207
  20. Coppinger JA, Cagney G, Toomey S, et al. Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Blood. 2004;103(March (6)):2096–2104
  21. May AE, Schmidt R, Bulbul BO, et al. Plasminogen and Matrix MetalloProteinase activation by enzymatically modified low density lipoproteins in monocytes and smooth muscle cells. Thromb Haemost. 2005;93(4):710–715
  22. Brach MA, Henschler R, Mertelsmann RH, Herrmann F. Regulation of M-CSF expression by M-CSF: role of protein kinase C and transcription factor NF kappa B. Pathobiology. 1991;59(4):284–288
  23. Brach MA, Arnold C, Kiehntopf M, Gruss HJ, Herrmann F. Transcriptional activation of the macrophage colony-stimulating factor gene by IL-2 is associated with secretion of bioactive macrophage colony-stimulating factor protein by monocytes and involves activation of the transcription factor NF-kappa B. J Immunol. 1993;150(June (12)):5535–5543
  24. Hohensinner PJ, Kaun C, Rychli K, et al. Macrophage colony stimulating factor expression in human cardiac cells is upregulated by tumor necrosis factor-alpha via an NF-kappaB dependent mechanism. J Thromb Haemost. 2007;5(12):2520–2528
  25. Rajavashisth TB, Yamada H, Mishra NK. Transcriptional activation of the macrophage-colony stimulating factor gene by minimally modified LDL. Involvement of nuclear factor-kappa B. Arterioscler Thromb Vasc Biol. 1995;15(10):1591–1598
  26. Devaraj S, Yun JM, Duncan-Staley C, Jialal I. C-reactive protein induces M-CSF release and macrophage proliferation. J Leukoc Biol. 2009;85(2):262–267
  27. Gawaz M, Stellos K, Langer HF. Platelets modulate atherogenesis and progression of atherosclerotic plaques via interaction with progenitor and dendritic cells. J Thromb Haemost. 2008;6(2):235–242
  28. Lusis AJ. Atherosclerosis. Nature. 2000;407(September (6801)):233–241
  29. Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation. 2002;105(March (9)):1135–1143
  30. Zhang J, Ge H, Wang C, et al. Inhibitory effect of PPAR on the expression of EMMPRIN in macrophages and foam cells. Int J Cardiol. 2007;117(May (3)):373–380
  31. Galat A. Peptidylproline cis-trans-isomerases: immunophilins. Eur J Biochem. 1993;216(September (3)):689–707
  32. Tegeder I, Schumacher A, John S, et al. Elevated serum cyclophilin levels in patients with severe sepsis. J Clin Immunol. 1997;17(5):380–386
  33. Billich A, Winkler G, Aschauer H, Rot A, Peichl P. Presence of cyclophilin A in synovial fluids of patients with rheumatoid arthritis. J Exp Med. 1997;185(March (5)):975–980
  34. Johnson JL, Baker AH, Oka K, et al. Suppression of atherosclerotic plaque progression and instability by tissue inhibitor of metalloproteinase-2: involvement of macrophage migration and apoptosis. Circulation. 2006;113(May (20)):2435–2444
  35. Tang Y, Nakada MT, Kesavan P, et al. Extracellular matrix metalloproteinase inducer stimulates tumor angiogenesis by elevating vascular endothelial cell growth factor and Matrix MetalloProteinases. Cancer Res. 2005;65(April (8)):3193–3199
  36. Dimmeler S, Burchfield J, Zeiher AM. Cell-based therapy of myocardial infarction. Arterioscler Thromb Vasc Biol. 2008;28(2):208–216

PII: S0021-9150(09)00692-3

doi: 10.1016/j.atherosclerosis.2009.08.029

Atherosclerosis
Volume 209, Issue 1 , Pages 51-57 , March 2010