Atherosclerosis
Volume 209, Issue 1 , Pages 28-31 , March 2010

The haptoglobin 2–2 genotype is associated with increased redox active hemoglobin derived iron in the atherosclerotic plaque

Received 1 September 2009

References 

  1. Bowman BH, Kurosky A. Haptoglobin: the evolutionary product of duplication, unequal crossing over, and point mutation. Adv Hum Genet. 1982;12:189–261
  2. Levy AP, Hochberg I, Jablonski K, et al. Haptoglobin phenotype and the risk of cardiovascular disease in individuals with diabetes: the strong heart study. J Am Coll Card. 2002;40:1984–1990
  3. Roguin A, Koch W, Kastrati A, et al. Haptoglobin genotype is predictive of major adverse cardiac events in the one year period after PTCA in individuals with diabetes. Diabetes Care. 2003;26:2628–2631
  4. Suleiman M, Aronson D, Asleh R, et al. Haptoglobin polymorphism predicts 30-day mortality and heart failure in patients with diabetes and acute myocardial infarction. Diabetes. 2005;19:2802–2806
  5. Milman U, Blum S, Shapira C, et al. Vitamin E supplementation reduces cardiovascular events in a subgroup of middle-aged individuals with both type 2 diabetes mellitus and the haptoglobin 2–2 genotype: a prospective, double-blinded clinical trial. Art Thromb Vasc Biol. 2008;28:341–347
  6. Costacou T, Ferrell RE, Orchard TJ. Haptoglobin genotype: a determinant of cardiovascular complication risk in type I diabetes. Diabetes. 2008;57:1702–1706
  7. Bamm VV, Tsemakhovich VA, Shaklai M, Shaklai N. Haptoglobin phenotypes differ in their ability to inhibit heme transfer from hemoglobin to LDL. Biochemistry. 2004;43:3899–3906
  8. Frank M, Lache O, Enav B, et al. Structure/function analysis of the anti-oxidant properties of haptoglobin. Blood. 2001;98:3693–3698
  9. Asleh R, Miller-Lotan R, Aviram M, et al. Haptoglobin genotype is a regulator of reverse cholesterol transport in diabetes in vitro and in vivo. Circ Res. 2006;99:1419–1425
  10. Kristiansen M, Graversen JH, Jacobsen C, et al. Identification of the hemoglobin scavenger receptor. Nature. 2001;409:198–201
  11. Asleh R, Marsh S, Shiltruck M, et al. Genetically determined heterogeneity in hemoglobin scavenging and susceptibility to diabetic cardiovascular disease. Circ Res. 2003;92:1193–1200
  12. Levy AP, Purosothaman KR, Levy NS, et al. Downregulation of the hemoglobin scavenger receptor in individuals with diabetes and the Hp 2–2 genotype: implications for the response to intraplaque hemorrhage and plaque vulnerability. Circ Res. 2007;101:106–110
  13. Levy AP, Levy JE, Kalet-Litman S, et al. Haptoglobin genotype is a determinant of iron, lipid peroxidation and macrophage accumulation in the atherosclerotic plaque. Art Thromb Vasc Biol. 2007;27:134–140
  14. Asleh R, Guetta J, Kalet-Litman S, Miller-Lotan R, Levy AP. Haptoglobin genotype and diabetes dependent differences in iron mediated oxidative stress in vitro and in vivo. Circ Res. 2005;96:435–441
  15. Van Dyke BR, Saltman P. Hemoglobin: a mechanism for the generation of hydroxyl radicals. Free Radic Biol Med. 1996;20:985–989
  16. Moreno PM, Purosothaman KR, Levy NS, et al. Haptoglobin genotype is a major determinant of iron in the human atherosclerotic plaque. J Am Coll Card. 2008;52:1049–1051
  17. Levy AP, Moreno PR. Intraplaque hemorrhage. Curr Mol Med. 2006;6:479–488

PII: S0021-9150(09)00715-1

doi: 10.1016/j.atherosclerosis.2009.09.002

Atherosclerosis
Volume 209, Issue 1 , Pages 28-31 , March 2010

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