Atherosclerosis
Volume 209, Issue 1 , Pages 39-41 , March 2010

An alternative pathway of reverse cholesterol transport: The oxysterol 27-hydroxycholesterol

  • Oliver Weingärtner

      Affiliations

    • Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, D-66421 Homburg/Saar, Germany
    • Corresponding Author InformationCorresponding author at: Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, D-66421 Homburg/Saar, Germany. Tel.: +49 6841 1621333; fax: +49 6841 1621331.
    • ,
  • Ulrich Laufs

      Affiliations

    • Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, D-66421 Homburg/Saar, Germany
    • ,
  • Michael Böhm

      Affiliations

    • Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, D-66421 Homburg/Saar, Germany
    • ,
  • Dieter Lütjohann

      Affiliations

    • Institut für klinische Chemie und Pharmakologie, Universitätsklinikum Bonn, D-53105 Bonn, Germany

Received 4 May 2009 ,Revised 7 September 2009 ,Accepted 9 September 2009.

References 

  1. Björkhelm I, Andersson O, Diczfalusy U, et al. Atherosclerosis and sterol 27-hydroxylase: evidence for a role of this enzyme in elimination of cholesterol from human macrophages. Proc Natl Acad Sci USA. 1994;91:8592–8596
  2. Reiss AB, Martin KO, Javitt NB, et al. Sterol 27-hydroxylase: high level activity in vascular endothelium. J Lipid Res. 1994;35:1026–1030
  3. Lütjohann D, Bjorkhem I, Beil UF, von Bergmann K. Sterol absorption and sterol balance in phytosterolemia evaluated by deuterium-labeled sterols: effect of sitostanol treatment. J Lipid Res. 1995;36:1763–1773
  4. Thelen KM, Rentsch KM, Gutteck U, et al. Brain cholesterol synthesis in mice is affected by high dose of simvastatin but not of pravastatin. J Pharmacol Exp Ther. 2006;316:1146–1152
  5. Miettinen TA, Tilvis RS, Kesaniemi YA. Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population. Am J Epidemiol. 1990;131:20–31
  6. Turley SD, Dietschy JM. The metabolism and excretion of cholesterol by the liver. In: Biology and pathobiology. 2nd edition. New York: Raven Press, Ltd., 1988. pp. 617–641.
  7. Pieters MN, Schouten D, Berkel TJV. In vitro and in vivo evidence for the role of HDL in reverse cholesterol transport. Biochim Biophys Acta. 1994;11:125–134
  8. Barter PJ, Caulfield M, Eriksson M, et al. Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med. 2007;357(21):2109–2122
  9. van der Steeg WA, Holme I, Boekholdt SM, et al. High-density lipoprotein cholesterol, high-density lipoprotein particle size, and apolipoprotein A–I: significance for cardiovascular risk: the IDEAL and EPIC-Norfolk studies. J Am Col Cardiol. 2008;51(6):634–642
  10. Babiker A, Dzeletovic S, Wiklund B, et al. Patients with atherosclerosis may have increased circulating levels of 27-hydroxycholesterol and cholestenoic acid. Scand J Clin Lab Invest. 2005;65:365–375
  11. Lund E, Andersson O, Zhang J, et al. Importance of a novel oxidative mechanism for elimination of intracellular cholesterol in humans. Arterioscler Thromb Vasc Biol. 1996;16:208–212
  12. Björkhelm I, Muri-Boberg K. Inborn errors in bile acid biosynthesis and storage of sterols other than cholesterol. In:  Sciver C,  Beaudet AL,  Sly WS,  Valle D editor. The metabolic basis of inherited diseases. New York, NY: Mc Graw Hill; 1994;p. 2073–2100
  13. von Bahr S, Movin T, Papadogiannakis N, et al. Mechanism of accumulation of cholesterol and cholestanol in tendons and the role of sterol 27-hydroxylase (CYP27A1). Arterioscler Thromb Vasc Biol. 2002;22:1129–1135

PII: S0021-9150(09)00728-X

doi: 10.1016/j.atherosclerosis.2009.09.015

Atherosclerosis
Volume 209, Issue 1 , Pages 39-41 , March 2010

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