Atherosclerosis
Volume 208, Issue 1 , Pages 28-29 , January 2010

Beyond the antioxidant properties: Pomegranate juice polyphenols increase hepatocyte paraoxonase 1 secretion

Received 15 September 2009 ,Revised 18 September 2009 ,Accepted 20 September 2009.

References 

  1. Soran H, Younis NN, Charlton-Menys V, Durrington P. Variation in paraoxonase-1 activity and atherosclerosis. Curr Opin Lipidol. 2009;20:265–274
  2. Seo D, Goldschmidt-Clermont P. The paraoxonase gene family and atherosclerosis. Curr Atheroscler Rep. 2009;11:182–187
  3. Khateeb J, Gantman A, Kreitenberg AJ, Aviram M, Fuhrman B, et al. Paraoxonase 1 (PON1) expression in hepatocytes is upregulated by pomegranate polyphenols: a role for PPAR-γ pathway. Atherosclerosis. 2010;208:119–125
  4. Aviram M, Kaplan M, Rosenblat M, Fuhrman B. Dietary antioxidants and paraoxonases against LDL oxidation and atherosclerosis development. Handb Exp Pharmacol. 2005;263–300
  5. Shiner M, Fuhrman B, Aviram M. Macrophage paraoxonase 2 (PON2) expression is up-regulated by pomegranate juice phenolic anti-oxidants via PPAR gamma and AP-1 pathway activation. Atherosclerosis. 2007;195:313–321
  6. Gong M, Garige M, Varatharajalu R, et al. Quercetin up-regulates paraoxonase 1 gene expression with concomitant protection against LDL oxidation. Biochem Biophys Res Commun. 2009;379:1001–1004

PII: S0021-9150(09)00785-0

doi: 10.1016/j.atherosclerosis.2009.09.032

Atherosclerosis
Volume 208, Issue 1 , Pages 28-29 , January 2010

Article Tools

* Image Usage & Resolution