Atherosclerosis
Volume 210, Issue 1 , Pages 57-62 , May 2010

Moderate kidney disease inhibits atherosclerosis regression

  • Manish P. Ponda

      Affiliations

    • Laboratory of Biochemical Genetics and Metabolism, Rockefeller University, New York, NY, United States
    • Division of Nephrology, Department of Medicine, New York University School of Medicine, New York, NY, United States
    • Corresponding Author InformationCorresponding author at: The Rockefeller University, 1230 York Avenue, Box 179, New York, NY 10065, United States. Tel.: +1 212 327 7631; fax: +1 212 327 7165.
  • ,
  • Irina Barash

      Affiliations

    • Division of Nephrology, Department of Medicine, New York University School of Medicine, New York, NY, United States
  • ,
  • Jonathan E. Feig

      Affiliations

    • Marc and Ruti Bell Vascular Biology Program, Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, NY, United States
  • ,
  • Edward A. Fisher

      Affiliations

    • Marc and Ruti Bell Vascular Biology Program, Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, NY, United States
    • Corresponding Author InformationCo-corresponding authors.
  • ,
  • Edward Y. Skolnik

      Affiliations

    • Division of Nephrology, Department of Medicine, New York University School of Medicine, New York, NY, United States
    • The Helen L. and Martin S. Kimmel Center for Biology and Medicine at the Skirball Institute for Biomolecular Medicine, United States
    • Corresponding Author InformationCo-corresponding authors.

Received 29 August 2009 ,Revised 10 October 2009 ,Accepted 16 October 2009.

References 

  1. Coresh J, Selvin E, Stevens LA, et al. Prevalence of chronic kidney disease in the United States. JAMA. 2007;298:2038–2047
  2. Beddhu S, Cheung AK, Larive B, et al. Inflammation and inverse associations of body mass index and serum creatinine with mortality in hemodialysis patients. J Ren Nutr. 2007;17:372–380
  3. Reis SE, Olson MB, Fried L, et al. Mild renal insufficiency is associated with angiographic coronary artery disease in women. Circulation. 2002;105:2826–2829
  4. Chen R, Kumar S, Timmis A, et al. Comparison of the relation between renal impairment, angiographic coronary artery disease, and long-term mortality in women versus men. Am J Cardiol. 2006;97:630–632
  5. Bro S, Bentzon JF, Falk E, et al. Chronic renal failure accelerates atherogenesis in apolipoprotein E-deficient mice. J Am Soc Nephrol. 2003;14:2466–2474
  6. Massy ZA, Ivanovski O, Nguyen-Khoa T, et al. Uremia accelerates both atherosclerosis and arterial calcification in apolipoprotein E knockout mice. J Am Soc Nephrol. 2005;16:109–116
  7. Shepherd J, Kastelein JJ, Bittner V, et al. Intensive lipid lowering with atorvastatin in patients with coronary heart disease and chronic kidney disease: the TNT (Treating to New Targets) study. J Am Coll Cardiol. 2008;51:1448–1454
  8. Wanner C, Krane V, Marz W, et al. Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis. N Engl J Med. 2005;353:238–248
  9. Fellstrom BC, Jardine AG, Schmieder RE, et al. Rosuvastatin and cardiovascular events in patients undergoing hemodialysis. N Engl J Med. 2009;360:1395–1407
  10. Williams KJ, Feig JE, Fisher EA. Cellular and molecular mechanisms for rapid regression of atherosclerosis: from bench top to potentially achievable clinical goal. Curr Opin Lipidol. 2007;18:443–450
  11. Williams KJ, Feig JE, Fisher EA. Rapid regression of atherosclerosis: insights from the clinical and experimental literature. Nat Clin Pract Cardiovasc Med. 2008;5:91–102
  12. Chereshnev I, Trogan E, Omerhodzic S, et al. Mouse model of heterotopic aortic arch transplantation. J Surg Res. 2003;111:171–176
  13. Llodra J, Angeli V, Liu J, et al. Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques. Proc Natl Acad Sci USA. 2004;101:11779–11784
  14. Trogan E, Fayad ZA, Itskovich VV, et al. Serial studies of mouse atherosclerosis by in vivo magnetic resonance imaging detect lesion regression after correction of dyslipidemia. Arterioscler Thromb Vasc Biol. 2004;24:1714–1719
  15. Trogan E, Feig JE, Dogan S, et al. Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice. Proc Natl Acad Sci USA. 2006;103:3781–3786
  16. Susztak K, Bitzer M, Meyer TW, Hostetter TH. Animal models of renal disease. Kidney Int. 2008;73:526–528
  17. Kirchhoff F, Krebs C, Abdulhag UN, et al. Rapid development of severe end-organ damage in C57BL/6 mice by combining DOCA salt and angiotensin II. Kidney Int. 2008;73:643–650
  18. Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med. 2004;351:1296–1305
  19. Buzello M, Tornig J, Faulhaber J, et al. The apolipoprotein E knockout mouse: a model documenting accelerated atherogenesis in uremia. J Am Soc Nephrol. 2003;14:311–316
  20. Posern G, Treisman R. Actin together: serum response factor, its cofactors and the link to signal transduction. Trends Cell Biol. 2006;16:588–596
  21. Riol-Blanco L, Sanchez-Sanchez N, Torres A, et al. The chemokine receptor CCR7 activates in dendritic cells two signaling modules that independently regulate chemotaxis and migratory speed. J Immunol. 2005;174:4070–4080
  22. D’Intini V, Bordoni V, Bolgan I, et al. Monocyte apoptosis in uremia is normalized with continuous blood purification modalities. Blood Purif. 2004;22:9–12
  23. Zuo Y, Yancey P, Castro I, et al. Renal dysfunction potentiates foam cell formation by repressing ABCA1. Arterioscler Thromb Vasc Biol. 2009;29:1277–1282
  24. Wang Z, Nicholls SJ, Rodriguez ER, et al. Protein carbamylation links inflammation, smoking, uremia and atherogenesis. Nat Med. 2007;13:1176–1184
  25. Ponda MP, Barash I. Lipid metabolism in dialysis patients – the story gets more complicated. Semin Dial. 2008;21:390–394

PII: S0021-9150(09)00903-4

doi: 10.1016/j.atherosclerosis.2009.10.029

Atherosclerosis
Volume 210, Issue 1 , Pages 57-62 , May 2010